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Featured researches published by Yp Chen.


Immunology and Cell Biology | 1997

Down-regulation of an Established Immune Response via Chemical Carcinogen or UVB-Altered Skin

Yp Chen; Gm Woods; Gw Dandie; Hk Muller

The ability to produce antigen‐specific down‐regulation of an established immune response was investigated in 2,4,6‐trinitrochlorobenzene (TNCB)‐immune mice by delivery of antigen through chemical carcinogen‐ or ultraviolet B (UVB)‐treated skin. When TNCB‐immune mice were treated on the dorsal trunk skin with 7,12‐dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen‐specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.


Cellular Immunology | 2001

Prevention of Autoimmunity by Induction of Cutaneous Tolerance

Gm Woods; Yp Chen; Al Dewar; Kv Doherty; Bh Toh; Hk Muller


Cellular Immunology | 1998

Induction of peripheral tolerance in neonatally thymectomized mice by immunization through chemical carcinogen-altered skin

Yp Chen; Hk Muller; K Scarff; Bh Toh; Gm Woods


7th International Workshop on Langerhans cells | 2001

Immature Langerhans cells: Central role in tolerance induction in carcinogen-treated and neonatal skin

Hk Muller; Kv Doherty; Al Dewar; Yp Chen; Bh Toh; Gm Woods


6th International Symposium on Dendritic Cells | 2000

Protection Against Autoimmune Disease by Immunisation Through Skin Containing Immature Langerhans Cells

Gm Woods; Yp Chen; Kv Doherty; Bh Toh; Hk Muller


1st Annual Meeting of the Haematology Society of Australia and New Zealand | 1999

Modification of dendritic cell function -Implications for autoimmunity

Gm Woods; Yp Chen; Kv Doherty; Al Dewar; Bh Toh; Hk Muller


Archive | 1998

Cutaneous tolerance induction : a possible strategy for the treatment of autoimmune disease

Yp Chen


37th Annual Meeting of the Australian Society for Medical Research | 1998

Modifying skin immunity

Gm Woods; Yp Chen; Kv Doherty; Bh Toh; Hk Muller


Federation of Immunological Societies of Asia-Oceania | 1996

Cutaneous tolerance -- A potential strategy for treatment of autoimmune disease

Yp Chen; Gm Woods; K Scarff; Bh Toh; Hk Muller


Experimental pathology | 1996

Downregulation of immune responses by modified dendritic cells

Hk Muller; Yp Chen; Gw Dandie; Gm Woods

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Gm Woods

University of Tasmania

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Hk Muller

University of Tasmania

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Kv Doherty

University of Tasmania

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Al Dewar

University of Tasmania

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Gw Dandie

University of Tasmania

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