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Dive into the research topics where Yu-Bin Zheng is active.

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Featured researches published by Yu-Bin Zheng.


ACS Nano | 2012

Electrical, Optical, and Docking Properties of Conical Nanopores

Yao-Qun Li; Yu-Bin Zheng; Richard N. Zare

The diffusion-influenced translocation behavior of individual nanoparticles upon passage through a conical nanopore has been elucidated by using a pressure-reversal, resistive-pulse technique, as reported by Lan and White in this issue of ACS Nano. We outline here some recent progress in conical nanopore analysis, and we present some prospects for future developments. Compared to cylindrical nanopores, the geometric change brought about by tapered nanopores causes a dramatic difference in electrical and optical properties. Such conical nanopores may also be integrated into microfluidic chips to capture cells or nanoparticles, one per nanopore, and then to release them. These advances hold the promise of making conical nanopores useful as highly efficient actuators and sensors.


Biosensors and Bioelectronics | 2015

Surface charge modulated aptasensor in a single glass conical nanopore

Sheng-Lin Cai; Shuo-Hui Cao; Yu-Bin Zheng; Shuang Zhao; Jin-Lei Yang; Yao-Qun Li

In this work, we have proposed a label-free nanopore-based biosensing strategy for protein detection by performing the DNA-protein interaction inside a single glass conical nanopore. A lysozyme binding aptamer (LBA) was used to functionalize the walls of glass nanopore via siloxane chemistry and negatively charged recognition sites were thus generated. The covalent modification procedures and their recognition towards lysozyme of the single conical nanopore were characterized via ionic current passing through the nanopore membrane, which was measured by recording the current-voltage (I-V) curves in 1mM KCl electrolyte at pH=7.4. With the occurring of recognition event, the negatively charged wall was partially neutralized by the positively charged lysozyme molecules, leading to a sensitive change of the surface charge-dependent current-voltage (I-V) characteristics. Our results not only demonstrate excellent selectivity and sensitivity towards the target protein, but also suggest a route to extend this nanopore-based sensing strategy to the biosensing platform designs of a wide range of proteins based on a charge modulation.


New Journal of Chemistry | 2015

Strong fluorescence emission localized at a tapered silver-plated sub-wavelength pore

Jin-Lei Yang; Shuo-Hui Cao; Qian Liu; Shuang Zhao; Yu-Bin Zheng; Yao-Qun Li

We observed up to 200 times fluorescence enhancement inside a tapered silver-plated sub-wavelength pore in comparison with the free space fluorescence. Fluorescence lifetime data was obtained to explore the strong fluorescence enhancement. The mechanism mainly arises from the silver film, the lateral dimensional shape, and size of the waveguide aperture.


Chemical Communications | 2016

A conformation and charge co-modulated ultrasensitive biomimetic ion channel

Sheng-Lin Cai; Yu-Bin Zheng; Shuo-Hui Cao; Xiu-Hong Cai; Yao-Qun Li

For the first time, a biomimetic ion channel co-modulated simultaneously by conformation and charge using a single stimulus has been demonstrated, and, based on the synergetic effect of this channel, an ultrasensitive nanopore sensor for ATP with a limit of detection down to sub-pM was developed.


Advanced Functional Materials | 2011

Smart Homopolymer Modification to Single Glass Conical Nanopore Channels: Dual-Stimuli-Actuated Highly Efficient Ion Gating

Li-Xiang Zhang; Sheng-Lin Cai; Yu-Bin Zheng; Xiao-Hong Cao; Yao-Qun Li


Electrochemistry Communications | 2010

Covalent modification of single glass conical nanopore channel with 6-carboxymethyl-chitosan for pH modulated ion current rectification

Li-Xiang Zhang; Xiao-Hong Cao; Yu-Bin Zheng; Yao-Qun Li


Nanoscale | 2017

A temperature, pH and sugar triple-stimuli-responsive nanofluidic diode

Yu-Bin Zheng; Shuang Zhao; Shuo-Hui Cao; Sheng-Lin Cai; Xiu-Hong Cai; Yao-Qun Li


Electrochemistry Communications | 2013

Sugar-stimulated robust nanodevice: 4-Carboxyphenylboronic acid modified single glass conical nanopores

Shuang Zhao; Yu-Bin Zheng; Sheng-Lin Cai; Yu-Hua Weng; Shuo-Hui Cao; Jin-Lei Yang; Yao-Qun Li


Mikrochimica Acta | 2016

A single glass conical nanopore channel modified with 6-carboxymethyl-chitosan to study the binding of bovine serum albumin due to hydrophobic and hydrophilic interactions

Sheng-Lin Cai; Li-Xiang Zhang; Kai Zhang; Yu-Bin Zheng; Shuang Zhao; Yao-Qun Li


Chinese Chemical Letters | 2015

Modulating ion current rectification generating high energy output in a single glass conical nanopore channel by concentration gradient

Li-Xiang Zhang; Yu-Bin Zheng; Sheng-Lin Cai; Xiao-Hong Cao; Yao-Qun Li

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