Yu. E. Alekseev

Coordination supramolecular structures

Supramolecular coordination ensembles with d-metal ions directly incorporated into their structures are the subject of the present review. Diversity of such structures considerably exceeds that of purely organic supramolecules due to inclusion of additional polyvalent metal atoms (totally sixty) with diverse coordination geometry. Such metal-containing constructions are generated by self-assembling and (or) by templating, as 2D and 3D geometric figures (polygons and polyhedra) and “furniture” constructions (ladders, racks, grids) together with helicates, interwoven species and metallodendrimers as combinations of 1D coordination compounds. Besides, is presented a numerous of coordination polymers and supramolecular crystal lattices as infinite structures.

O-Hetaryl substituted carbohydrates and their neurotropic activity

Nand C-substituted monosaccharides, incluing their hetaryl derivatives, have found rather extensive application in clinlcal practlce as inhlbltors of nucleic acldmetabollsmwlth anticancer, antivirus, and immunodepressant activity [16]. C-Hetaryl-substituted carbohydrates [5], among which derivatives with anticoagulant [6], antimicrobial [8], and neurotropic activity [8] have been discovered, are of particular interest as a consequence of their fundamental nonhydrolyzability with respect to the C-C bond both in vito and in vitro [6]; this probably also facilitates the manifestation of interesting pharmacological properties by them.