Yu. I. Borodin

Effects of Bone Marrow Multipotent Mesenchymal Stromal Cells and Their Secretory Products on Microcirculation in the Broad Ligament of the Uterus of Wistar Rats during Experimental Chronic Genital Inflammation

Effects of bone marrow multipotent mesenchymal stromal cells and their secretory products released into the conditioned medium on microcirculatory bed in the broad ligament of the uterus were studied in Wistar rats with chronic genital inflammation. Opposite changes in the parameters of microcirculation and lymphatic drainage in the broad ligament of the uterus were observed after administration of cells and conditioned medium via different routes, which should be taken into account during the treatment of inflammatory and degenerative processes in the pelvic organs.

Cell Composition of Central and Peripheral Lymphoid Organs of Wistar Rats Treated with a Biomedical Cell Product.

We studied the effect of a biomedical cell product (bone marrow multipotent mesenchymal stromal cells and products secreted by these cells in conditioned medium) on subpopulation composition of lymphoid cells of central and peripheral lymphoid organs of Wistar rats under normal conditions. Changes in the subpopulation composition of lymphoid organs depended on the route of administration of biomedical cell product.

Parameters of Microcirculation in the Broad Ligament of the Uterus in Wistar Rats after Injection of Autologous Biomedical Cell Product

We studied the effects of autologous biomedical cell product (bone marrow multipotent mesenchymal stromal cells and their conditioned media) on the parameters of the microcirculatory bed in the broad ligament of the uterus of normal Wistar rats were studied. The parameters of microcirculation and lymph drainage in the broad ligament changed in opposite directions in response to injection of autologous biomedical cell product via different routes. This fact should be taken into consideration when prescribing cell therapy for inflammatory degenerative processes in the pelvic organs.

Character of change in the thermal conductivity coefficient of rabbit lymph in different parts of the lymphatic system

The thermal conductivity coefficient of lymph in various parts of the lymphatic system was measured with microthermistors. Starvation was found to affect the thermal conductivity coefficient of lymph of the intestinal trunk and the temperature of the lymph in the thoracic duct affected its thermal conductivity coefficient.

Expression of Molecular Markers of Angiogenesis, Lymphangiogenesis, and Proliferation Depending on the Stage of Skin Melanoma.

The expression of molecular markers characterizing activity of the tumor process and metastases (proliferation marker Ki-67, angiogenesis marker CD34, and lymphangiogenesis markers podoplanin and LYVE-1) was assessed by immunohictochemical method in the primary tumor specimens collected during surgery for cutaneous melanoma (40 patients). Proliferative activity of the tumor tissue and volume density of peritumoral blood and lymph vessels increased with increasing tumor malignancy, which could indicate the risk of metastases.

Lymph Region in the Female Internal Reproductive Organs during the Early Postpartum Period after Normal Pregnancy

The structural and functional changes in the lymph region of the female internal reproductive organs in rats were studied during the early postpartum period after normal pregnancy. The results indicated that the main role of the lymph region in pregnancy consisted in supporting sufficient lymph production and drainage in the hypertrophic uterus.

Expression of intracellular molecular apoptosis regulator Bcl-2 in the liver in isolated and combined exposure to 24-h illumination and industrial frequency magnetic field

We studied the effect of isolated and combined exposure to 24-h illumination and industrial frequency magnetic field on the expression of intracellular molecular apoptosis regulator Bcl-2 in the liver. Previous experiments showed enhanced expression of Bcl-2 protein in liver cells in animals maintained under conditions of 24-h illumination, whereas exposure to industrial frequency magnetic field had practically no effect on this process. Under conditions of combined exposure to 24-h illumination and industrial frequency magnetic field, magnetic field partially suppressed the expression of Bcl-2 induced by 24-h illumination.

Electrical impedancometry technique for the evaluation of myocardial infarction

The energy metabolism of cell,organ, and tissue changes under the influence on a biological object of different physical and chemical factors of the external and internal environment: temperature, pressure. volume, electrolyte concentration, stress on functional systems, as well as pathological changes [3,6]. It will thus be correct to say that passive electric properties carry information about the state and functioning of not only an organ, but also the organism as a whole. In this connection it is important to find an indicator, which could depict the phenomenon of polarization mostly completely and carry information about the state of energy exchange. Electrical resisance is usually measured in biological objects. The modulus of the whole electrical resistance, expressed by the formula: X = Ro + R , where Ro is the ohmic resistance R c the capacitive resistance, is called impedance. In the measurement of impedance the frequency of the test current has great significance. Frequencies of 106 and 104 Hz were selected for impedance measurement, because the maximum electroconduetivity of an object is determined at a frequency of 106 Hz, and a break of the dispersion curve is observed at a frequency of 104 Hz. The ratio of impedance measured at a the frequency of 104 to impedance measured at a the frequency of 106 Hz is the coefficient of polarization dispersion, or CPD [5]. Its value in normal intact cells and tissues depends upon the position of the biological object in the evolutionary ranking.

Structural and functional transformations of the iliac lymph nodes during pregnancy complicated by hemorrhage

Much has been published on the study of the circulation in the lymph-blood system after blood loss [1, 2]. Nevertheless, the morphologic and functional state of lymph nodes regional with respect to the reproductive organs during pregnancy complicated by hemorrhage, still remains unexplained (bearing in mind the fact that by the end of a physiological pregnancy the lymph nodes have undergone considerable transformations [4]). This investigation becomes increasingly more urgent if we look at the clinical data: among the causes of death in obsteric practice hemorrhage accounts for 20-25% of cases [3].

Neurotransmitter provision for organs of the immune system during benzpyrene poisioning

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