Yu Luoting
Sichuan University
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Publication
Featured researches published by Yu Luoting.
PLOS ONE | 2013
Song Xuejiao; Xia Yong; Wang Ningyu; Zhang Lidan; Shi Xuanhong; Xu Youzhi; Ye Tinghong; Shi Yaojie; Zhu Yongxia; Yu Luoting
Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy has received considerable attention in recent years. YLT322, a novel synthesized benzothiazole derivative, exhibits potent anti-tumor activity via inducing apoptosis both in vitro and in vivo. In this study, we found that YLT322 showed growth inhibition against a broad spectrum of human cancer cells and induced apoptosis of HepG2 cells in a dose- and time-dependent manner. The occurrence of its apoptosis was associated with activation of caspases-3 and -9, but not caspase-8. YLT322 increased the expression of Bax, decreased the expression of Bcl-2, and induced the release of cytochrome c which activates the mitochondrial apoptotic pathway. The down-regulation of phosphorylated p42/44 MAPK and phosphorylated Akt was also observed. Moreover, YLT322 suppressed the growth of established tumors in xenograft models in mice without obvious side effects. Histological and immunohistochemical analyses revealed an increase in TUNEL and caspase-3-positive cells and a decrease in Ki67-positive cells upon YLT322. These results suggest that YLT322 may be a potential candidate for cancer therapy.
Archive | 2014
Yu Luoting; Wei Yuquan
Archive | 2015
Zhang Yang; Shen Chunli; Li Jian; Chen Shuhui; Wei Yuquan; Yu Luoting; Tao Xin; Hu Guoping
Archive | 2013
Yu Luoting; Wei Yuquan
Archive | 2016
Zhang Yang; Fu Zhifei; Wang Jianfei; Li Jian; Chen Shuhui; Wei Yuquan; Yu Luoting; Tao Xin
Archive | 2015
Chen Shuhui; Zhu Wenyuan; Wang Jianfei; Li Jian; Wei Yuquan; Yu Luoting; Tao Xin
Archive | 2013
Song Xiangrong; Yu Luoting; Zhao Yinglan; Yang Shengyong; Wei Yuquan
Archive | 2013
Yu Luoting; Wei Yuquan
Archive | 2017
Yu Luoting; Wei Yuquan
Archive | 2017
Zhang Yang; Fu Zhifei; Wang Jianfei; Li Jian; Chen Shuhui; Wei Yuquan; Yu Luoting; Tao Xin