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Dive into the research topics where Yu Luoting is active.

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Featured researches published by Yu Luoting.


PLOS ONE | 2013

A Novel Benzothiazole Derivative YLT322 Induces Apoptosis via the Mitochondrial Apoptosis Pathway In Vitro with Anti-Tumor Activity in Solid Malignancies

Song Xuejiao; Xia Yong; Wang Ningyu; Zhang Lidan; Shi Xuanhong; Xu Youzhi; Ye Tinghong; Shi Yaojie; Zhu Yongxia; Yu Luoting

Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy has received considerable attention in recent years. YLT322, a novel synthesized benzothiazole derivative, exhibits potent anti-tumor activity via inducing apoptosis both in vitro and in vivo. In this study, we found that YLT322 showed growth inhibition against a broad spectrum of human cancer cells and induced apoptosis of HepG2 cells in a dose- and time-dependent manner. The occurrence of its apoptosis was associated with activation of caspases-3 and -9, but not caspase-8. YLT322 increased the expression of Bax, decreased the expression of Bcl-2, and induced the release of cytochrome c which activates the mitochondrial apoptotic pathway. The down-regulation of phosphorylated p42/44 MAPK and phosphorylated Akt was also observed. Moreover, YLT322 suppressed the growth of established tumors in xenograft models in mice without obvious side effects. Histological and immunohistochemical analyses revealed an increase in TUNEL and caspase-3-positive cells and a decrease in Ki67-positive cells upon YLT322. These results suggest that YLT322 may be a potential candidate for cancer therapy.


Archive | 2014

Benzothiazine-thione derivatives, preparation method thereof and purpose thereof

Yu Luoting; Wei Yuquan


Archive | 2015

Hepatitis C virus inhibitors and pharmaceutical uses thereof

Zhang Yang; Shen Chunli; Li Jian; Chen Shuhui; Wei Yuquan; Yu Luoting; Tao Xin; Hu Guoping


Archive | 2013

2-(6-aminobenzothiazole-2-mercapto)-acetamide derivatives and preparation method and applications thereof

Yu Luoting; Wei Yuquan


Archive | 2016

BENZOFURAN ANALOGUE AS NS4B INHIBITOR

Zhang Yang; Fu Zhifei; Wang Jianfei; Li Jian; Chen Shuhui; Wei Yuquan; Yu Luoting; Tao Xin


Archive | 2015

Thiophene adopted as hepatitis C virus inhibitor or variant derivative thereof, and pharmaceutical uses thereof

Chen Shuhui; Zhu Wenyuan; Wang Jianfei; Li Jian; Wei Yuquan; Yu Luoting; Tao Xin


Archive | 2013

4-(4-benzamido-phenoxyl)-2-(methyl-carbamyl) pyridine derivative or solid dispersion of salt derivative, as well as preparation method of derivative or solid dispersion

Song Xiangrong; Yu Luoting; Zhao Yinglan; Yang Shengyong; Wei Yuquan


Archive | 2013

BENZOTHIAZINE-4-ONE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

Yu Luoting; Wei Yuquan


Archive | 2017

2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative and preparing method and application thereof

Yu Luoting; Wei Yuquan


Archive | 2017

NS4B BENZOFURAN ANALOGUE AS NS4B INHIBITOR

Zhang Yang; Fu Zhifei; Wang Jianfei; Li Jian; Chen Shuhui; Wei Yuquan; Yu Luoting; Tao Xin

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