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Dive into the research topics where Yu Ming Hsu is active.

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Featured researches published by Yu Ming Hsu.


Pharmacology & Therapeutics | 2013

Recent research and development of Antrodia cinnamomea.

Mei Chin Lu; Mohamed El-Shazly; Tung Ying Wu; Ying Chi Du; Tun Tschu Chang; Chieh Fu Chen; Yu Ming Hsu; Kuei Hung Lai; Ching Peng Chiu; Fang Rong Chang; Yang Chang Wu

Medicinal mushrooms have attracted much attention recently owing to their potent therapeutic activity, especially as chemopreventive and immunomodulatory agents. Antrodia cinnamomea is a treasured Taiwanese mushroom that has been used by aboriginal tribes for centuries to treat food intoxication and to enhance liver functions. It was included in Asian folk medicine in the last few decades with remarkable results in treating inflammatory disorders, cancers, hypertension and hepatitis. This myriad of therapeutic activities encouraged several research groups to subject A. cinnamomea to intensive biological and phytochemical investigation, leading to the isolation of different classes of pharmacologically active secondary metabolites. The in vitro and in vivo biological results of the mushroom extracts and its active components revealed their potent cytotoxic, anti-inflammatory and hepatoprotective activities. The aim of this study is to review recent reports on the biological activities of A. cinnamomea extracts and its active components; quality control protocols; synthetic methodologies for the preparation of active components; developed culture techniques; phylogenetic analysis and gene cloning. This study also tackles major challenges facing future expansion of A. cinnamomea production.


Phytochemistry | 2013

1,5-Diphenylpent-3-en-1-ynes and methyl naphthalene carboxylates from Lawsonia inermis and their anti-inflammatory activity.

Jing Ru Liou; Mohamed El-Shazly; Ying Chi Du; Chao Neng Tseng; Tsong Long Hwang; Yueh Lin Chuang; Yu Ming Hsu; Pei Wen Hsieh; Chin Chun Wu; Shu Li Chen; Ming Feng Hou; Fang Rong Chang; Yang Chang Wu

Lawsonia inermis (Lythraceae) known as henna is one of the most popular and ancient plants used in cosmetics and hair dying. It is cultivated for its leaves but other parts such as seeds, flowers, stem bark and roots are also used in traditional medicine for millennia. Henna tattoo paste also proved to be beneficial for wound healing and in several skin diseases suggesting potent anti-inflammatory activity. To evaluate henna anti-inflammatory activity, 31 compounds, including three 1,5-diphenylpent-3-en-1-yne derivatives, lawsochylin A-C and three methyl naphthalene carboxylates, lawsonaphthoate A-C, were isolated from the stems and leaves of henna utilizing a bioassay-guided fractionation. The structures of the compounds were elucidated by spectroscopic data. Two compounds, lawsochylin A and lawsonaphthoate A showed potent anti-inflammatory activity by inhibition of superoxide anion generation (IC(50)=1.80 and 1.90 μg/ml) and elastase release (IC(50)=1.58 and 3.17 μg/ml) of human neutrophils in response to fMLP or cytochalasin B. Moreover, the known compounds, luteolin, apigenin, 4S-4-hydroxy-α-tetralone, and 2-butoxysuccinic acid, also showed potent inhibition of superoxide anion generation (IC(50)=0.75-1.78 μg/ml) and elastase release (IC(50)=1.62-3.61 μg/ml).


Phytomedicine | 2012

Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models

Ying Chi Du; Fang Rong Chang; Tung Ying Wu; Yu Ming Hsu; Mohamed El-Shazly; Chieh Fu Chen; Ping-Jyun Sung; Yan Yu Lin; Yi Hsin Lin; Yang Chang Wu; Mei Chin Lu

Antrodia camphorata (AC) is a native Taiwanese mushroom which is used in Asian folk medicine as a chemopreventive agent. The triterpenoid-rich fraction (FEA) was obtained from the ethanolic extract of AC and characterized by high performance liquid chromatography (HPLC). FEA caused DNA damage in leukemia HL 60 cells which was characterized by phosphorylation of H2A.X and Chk2. It also exhibited apoptotic effect which was correlated to the enhancement of PARP cleavage and to the activation of caspase 3. Five major triterpenoids, antcin K (1), antcin C (2), zhankuic acid C (3), zhankuic acid A (4), and dehydroeburicoic acid (5) were isolated from FEA. The cytotoxicity of FEA major components (1-5) was investigated showing that dehydroeburicoic acid (DeEA) was the most potent cytotoxic component. DeEA activated DNA damage and apoptosis biomarkers similar to FEA and also inhibited topoisomerase II. In HL 60 cells xenograft animal model, DeEA treatment resulted in a marked decrease of tumor weight and size without any significant decrease in mice body weights. Taken together, our results provided the first evidence that pure AC component inhibited tumor growth in vivo model backing the traditional anticancer use of AC in Asian countries.


Journal of Pharmaceutical and Biomedical Analysis | 2012

Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata

Ying Chi Du; Tung Ying Wu; Fang Rong Chang; Wan-Yu Lin; Yu Ming Hsu; Fu Ting Cheng; Chi Yu Lu; Ming Hong Yen; Ya Ting Tsui; Hsuan Lun Chen; Ming Feng Hou; Mei Chin Lu; Yang Chang Wu

Antrodia camphorata (AC), also known as Antrodia cinnamomea, an endemic species in Taiwan, is one of the treasured medicinal mushrooms. AC is traditionally used for its chemopreventive biofunctions. In this investigation, we report a convenient method for concentrating the antiproliferative active triterpenoid-rich fraction (FEA), from ethanolic extract of AC (EEAC). A series of stereo-isomers of zhankuic acids (1-8) from the FEA was purified by HPLC using an efficient acidic solvent system. The structures of compounds 1-8 were elucidated based on spectroscopic data analysis, and the absolute configuration of α-chiral carboxylic acid at C-25 in the structures was assigned based on reaction with (R)- and (S)-1-(9-anthryl)-2,2,2-trifluoroethanol. Major ingredients of FEA (eight ergostanes 1-8 and two lanostanes 9-10) were further characterised by high-performance liquid chromatography-photodiode array detection/mass spectrometry (HPLC-PDA/MS). Compounds 1-8 and their pair mixture forms (antcin K, antcin C, zhankuic acid C, and zhankuic acid A) were subjected to anti-proliferative assay against three human leukemia cell lines. Among them, the derivatives with carbonyl group at C-3 showed cytotoxicity with IC(50) values ranging from 16.44 to 77.04 μg/ml.


Molecules | 2014

Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

Shu Fen Tu; Rosa Huang Liu; Yuan Bin Cheng; Yu Ming Hsu; Ying Chi Du; Mohamed El-Shazly; Yang Chang Wu; Fang Rong Chang

Four new sulfur-containing compounds, named clinamides A-C (1–3), and 2-cis-entadamide A (4), were isolated together with three known compounds from the bioactive ethanol extract of the aerial parts of Clinacanthus nutans. These secondary metabolites possess sulfur atoms and acrylamide functionalities. The structures of the isolated components were established by interpretation of their spectroscopic data, especially 1D and 2D NMR.


Phytochemistry | 2016

3-Methyl-4,5-dihydro-oxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity

Yu Ming Hsu; Tung Ying Wu; Ying Chi Du; Mohamed El-Shazly; Ludger Beerhues; Tran Dinh Thang; Hoang Van Luu; Tsong Long Hwang; Fang Rong Chang; Yang Chang Wu

The phytochemical investigation of the methanolic extract of Uvaria flexuosa (Annonaceae) leaves led to the isolation of seven compounds including, 3-methyl-4,5-dihydro-oxepine (flexuvaroxepine A), four polyoxygenated seco-cyclohexene (flexuvarin A-D) and two polyoxygenated cyclohexene (flexuvarol A-B) derivatives, together with four known flavones. The structures of the isolated compounds were elucidated using different spectroscopic techniques. A plausible biogenetic route of the new compounds was discussed. The anti-inflammatory activity of the isolated compounds was evaluated by superoxide anion generation and elastase release assays. Among the tested compounds, flexuvarol B and chrysin showed the most potent anti-inflammatory effect by inhibiting superoxide anion generation and elastase release from human neutrophils in response to fMLP with IC50 2.25-5.55μM. Moreover, 5-hydroxy-6,7-dimethoxy-flavone showed selective inhibitory activity on superoxide anion generation (IC50=1.19±0.34μM).


International Journal of Molecular Sciences | 2016

Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis

Michal Korinek; Vitthal D. Wagh; I. Wen Lo; Yu Ming Hsu; Hsue Yin Hsu; Tsong Long Hwang; Yang Chang Wu; Yuan Bin Cheng; Bing-Hung Chen; Fang Rong Chang

The Aquilaria malaccensis (Thymelaeaceae) tree is a source of precious fragrant resin, called agarwood, which is widely used in traditional medicines in East Asia against diseases such as asthma. In our continuous search for active natural products, A. malaccensis seeds ethanolic extract demonstrated antiallergic effect with an IC50 value less than 1 µg/mL. Therefore, the present research aimed to purify and identify the antiallergic principle of A. malaccensis through a bioactivity-guided fractionation approach. We found that phorbol ester-rich fraction was responsible for the antiallergic activity of A. malaccensis seeds. One new active phorbol ester, 12-O-(2Z,4E,6E)-tetradeca-2,4,6-trienoylphorbol-13-acetate, aquimavitalin (1) was isolated. The structure of 1 was assigned by means of 1D and 2D NMR data and high-resolution mass spectrometry (HR-MS). Aquimavitalin (1) showed strong inhibitory activity in A23187- and antigen-induced degranulation assay with IC50 values of 1.7 and 11 nM, respectively, with a therapeutic index up to 71,000. The antiallergic activities of A. malaccensis seeds and aquimavitalin (1) have never been revealed before. The results indicated that A. malaccensis seeds and the pure compound have the potential for use in the treatment of allergy.


Free Radical Biology and Medicine | 2017

6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury

Yung Fong Tsai; Tzu Chi Chu; Wen Yi Chang; Yang Chang Wu; Fang Rong Chang; Shun Chin Yang; Tung Ying Wu; Yu Ming Hsu; Chun Yu Chen; Shih Hsin Chang; Tsong Long Hwang

Abstract Over‐activated neutrophils produce enormous oxidative stress and play a key role in the development of acute and chronic inflammatory diseases. 6‐Hydroxy‐5,7‐dimethoxy‐flavone (UFM24), a flavone isolated from the Annonaceae Uvaria flexuosa, showed inhibitory effects on human neutrophil activation and salutary effects on lipopolysaccharide (LPS)‐induced acute lung injury (ALI) in mice. UFM24 potently inhibited superoxide anion (O2•−) generation, reactive oxidants, and CD11b expression, but not elastase release, in N‐formyl‐l‐methionyl‐l‐leucyl‐l‐phenylalanine (fMLF)‐activated human neutrophils. However, UFM24 failed to scavenge O2•− and inhibit the activity of subcellular NADPH oxidase. fMLF‐induced phosphorylation of protein kinase B (Akt) was inhibited by UFM24. Noticeably, UFM24 increased cyclic adenosine monophosphate (cAMP) concentration and protein kinase (PK) A activity in activated human neutrophils. PKA inhibitors significantly reversed the inhibitory effects of UFM24, suggesting that the effects of UFM24 were through cAMP/PKA‐dependent inhibition of Akt activation. Additionally, activity of cAMP‐related phosphodiesterase (PDE)4, but not PDE3 or PDE7, was significantly reduced by UFM24. Furthermore, UFM24 attenuated neutrophil infiltration, myeloperoxidase activity, and pulmonary edema in LPS‐induced ALI in mice. In conclusion, our data demonstrated that UFM24 inhibits oxidative burst in human neutrophils through inhibition of PDE4 activity. UFM24 also exhibited significant protection against endotoxin‐induced ALI in mice. UFM24 has potential as an anti‐inflammatory agent for treating neutrophilic lung damage. Graphical abstract Figure. No Caption available. HighlightsUFM24 inhibits respiratory burst in activated neutrophils with an IC50 at 0.22 &mgr;M.UFM24 attenuates LPS‐resulted acute lung injury in mice.UFM24 enhances cAMP/PKA‐dependent inhibition of Akt activation.UFM24 is a natural PDE4 inhibitor.


Journal of Natural Products | 2016

Cytotoxic Lanostanoids from Poria cocos

Kuei Hung Lai; Mei Chin Lu; Ying Chi Du; Mohamed El-Shazly; Tung Ying Wu; Yu Ming Hsu; Astrid Henz; Juan Cheng Yang; Anders Backlund; Fang Rong Chang; Yang Chang Wu


Helvetica Chimica Acta | 2014

Chemical Constituents of the Leaves of Desmos cochinchinensis var. fulvescens Ban

Tung Ying Wu; Yuan Bin Cheng; Fu Ting Cheng; Yu Ming Hsu; Thang Tran Dinh; Fang Rong Chang; Yang Chang Wu

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Fang Rong Chang

Kaohsiung Medical University

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Yang Chang Wu

Kaohsiung Medical University

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Ying Chi Du

Kaohsiung Medical University

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Mei Chin Lu

National Dong Hwa University

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Ming Feng Hou

Kaohsiung Medical University

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Yuan Bin Cheng

Kaohsiung Medical University

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Fu Ting Cheng

Kaohsiung Medical University

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