Yu Ryan Yue

Bayesian inference for additive mixed quantile regression models

Quantile regression problems in practice may require flexible semiparametric forms of the predictor for modeling the dependence of responses on covariates. Furthermore, it is often necessary to add random effects accounting for overdispersion caused by unobserved heterogeneity or for correlation in longitudinal data. We present a unified approach for Bayesian quantile inference on continuous response via Markov chain Monte Carlo (MCMC) simulation and approximate inference using integrated nested Laplace approximations (INLA) in additive mixed models. Different types of covariate are all treated within the same general framework by assigning appropriate Gaussian Markov random field (GMRF) priors with different forms and degrees of smoothness. We applied the approach to extensive simulation studies and a Munich rental dataset, showing that the methods are also computationally efficient in problems with many covariates and large datasets.

Meta-analysis of functional neuroimaging data using Bayesian nonparametric binary regression

In this work we perform a meta-analysis of neuroimaging data, consisting of locations of peak activations identified in 162 separate studies on emotion. Neuroimaging meta-analyses are typically performed using kernel-based methods. However, these methods require the width of the kernel to be set a priori and to be constant across the brain. To address these issues, we propose a fully Bayesian nonparametric binary regression method to perform neuroimaging meta-analyses. In our method, each location (or voxel) has a probability of being a peak activation, and the corresponding probability function is based on a spatially adaptive Gaussian Markov random field (GMRF). We also include parameters in the model to robustify the procedure against miscoding of the voxel response. Posterior inference is implemented using efficient MCMC algorithms extended from those introduced in Holmes and Held [Bayesian Anal. 1 (2006) 145--168]. Our method allows the probability function to be locally adaptive with respect to the covariates, that is, to be smooth in one region of the covariate space and wiggly or even discontinuous in another. Posterior miscoding probabilities for each of the identified voxels can also be obtained, identifying voxels that may have been falsely classified as being activated. Simulation studies and application to the emotion neuroimaging data indicate that our method is superior to standard kernel-based methods.

Bayesian Tobit quantile regression model for medical expenditure panel survey data

High expenditure on healthcare is an important segment of the U.S. economy, making healthcare cost modelling valuable in decision-making processes over a wide array of domains. In this paper, we analyze medical expenditure panel survey (MEPS) data. Tobit regression model has been popularly used for the medical expenditures. However, it is no longer sufficient for the MEPS data because: (i) the distribution of the expenditures shows skewness, heavy tails and heterogeneity; (ii) most predictors are categorical, including binary, nominal and ordinal variables; (iii) there are a few predictors which may be nonlinearly related to the response. We therefore propose a Bayesian Tobit quantile regression model to describe a complete distributional view on how the medical expenditures depend on the various predictors. Specifically, we assume an asymmetric Laplace error distribution to adapt the quantile regression to a Bayesian setting. Then, we propose a modified group Lasso for categorical factor selection, and a smoothing Gaussian prior for modelling the nonlinear effects. The estimates and their uncertainties are obtained using an efficient Monte Carlo Markov Chain sampling method. The effectiveness of our approach is demonstrated by modelling 2007 MEPS data.

Bayesian semiparametric intensity estimation for inhomogeneous spatial point processes.

In this work we propose a fully Bayesian semiparametric method to estimate the intensity of an inhomogeneous spatial point process. The basic idea is to first convert intensity estimation into a Poisson regression setting via binning data points on a regular grid, and then model the log intensity semiparametrically using an adaptive version of Gaussian Markov random fields to smooth the corresponding counts. The inference is carried by an efficient Markov chain Monte Carlo simulation algorithm. Compared to existing methods for intensity estimation, for example, parametric modeling and kernel smoothing, the proposed estimator not only provides inference regarding the dependence of the intensity function on possible covariates, but also uses information from the data to adaptively determine the amount of smoothing at the local level. The effectiveness of using our method is demonstrated through simulation studies and an application to a rainforest dataset.

Bayesian adaptive smoothing splines using stochastic differential equations

The smoothing spline is one of the most popular curve-fitting methods, partly because of empirical evidence supporting its effectiveness and partly because of its elegant mathematical formulation. However, there are two obstacles that restrict the use of smoothing spline in practical statistical work. Firstly, it becomes computationally prohibitive for large data sets because the number of basis functions roughly equals the sample size. Secondly, its global smoothing parameter can only provide constant amount of smoothing, which often results in poor performances when estimating inhomogeneous functions. In this work, we introduce a class of adaptive smoothing spline models that is derived by solving certain stochastic differential equations with finite element methods. The solution extends the smoothing parameter to a continuous data-driven function, which is able to capture the change of the smoothness of underlying process. The new model is Markovian, which makes Bayesian computation fast. A simulation study and real data example are presented to demonstrate the effectiveness of our method.

Bayesian nonparametric estimation of pair correlation function for inhomogeneous spatial point processes

The pair correlation function (PCF) is a useful tool for studying spatial point patterns. It is often estimated by some nonparametric approach such as kernel smoothing. However, the statistical properties of the kernel estimator are highly dependent on the choice of bandwidth. An inappropriate value of the bandwidth may lead to an estimator with a large bias or variance or both. In this work, we present an alternative PCF estimator based on Bayesian nonparametric regression. The method provides data-driven smoothing and intuitive uncertainty measures, together with efficient computation. The merits of our method are demonstrated via a simulation study and a couple of applications involving astronomy data and data on restaurant locations.

Bayesian inference for generalized linear mixed models with predictors subject to detection limits: an approach that leverages information from auxiliary variables

This paper is motivated from a retrospective study of the impact of vitamin D deficiency on the clinical outcomes for critically ill patients in multi-center critical care units. The primary predictors of interest, vitamin D2 and D3 levels, are censored at a known detection limit. Within the context of generalized linear mixed models, we investigate statistical methods to handle multiple censored predictors in the presence of auxiliary variables. A Bayesian joint modeling approach is proposed to fit the complex heterogeneous multi-center data, in which the data information is fully used to estimate parameters of interest. Efficient Monte Carlo Markov chain algorithms are specifically developed depending on the nature of the response. Simulation studies demonstrate the outperformance of the proposed Bayesian approach over other existing methods. An application to the data set from the vitamin D deficiency study is presented. Possible extensions of the method regarding the absence of auxiliary variables, semiparametric models, as well as the type of censoring are also discussed.