Yu-Ting Ye

Syntheses, characterization, and urease inhibition of oxidovanadium(V) complexes with tridentate hydrazone and bidentate benzohydroxamate ligands

New oxidovanadium(V) complexes, [VOL1(bzh))]·H2O (1) and [VOL2(bzh))] (2), were prepared by the reaction of [VO(acac)2] (where acac = acetylacetonate) and benzohydroxamic acid (Hbzh) with N′-(5-bromo-2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L1) and N′-(5-bromo-2-hydroxybenzylidene)-4-methylbenzohydrazide (H2L2), respectively, in methanol. Structures of the complexes were determined by elemental analysis, infrared and UV–vis spectra. Single crystal structures of the complexes were determined by X-ray diffraction. Vanadiums have octahedral coordination. Thermal stability and the inhibition of urease of the complexes were studied. Graphical Abstract

Synthesis, Characterization, and Crystal Structures of New Oxovanadium(V) Complexes With Mixed Nicotinohydrazone and 8-Hydroxyquinoline Ligands

Two similar oxovanadium(V) complexes, [VOL1L′] (1) and [VOL2L′] (2), were prepared by the reaction of [VO(acac)2] (where acac = acetylacetonate), 8-hydroxyquinoline (HL′) with N′-(5-fluoro-2-hydroxybenzylidene)nicotinohydrazide (H2L1) and N′-(3-bromo-5-chloro-2-hydroxybenzylidene)nicotinohyrazide (H2L2), respectively, in methanol. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared, and UV-vis spectra and single-crystal X-ray diffraction. The nicotinohydrazone ligands coordinate to the V atoms through the phenolate oxygen, imino nitrogen, and enolate oxygen. The 8-hydroxyquinoline ligand coordinates to the V atom through the phenolate oxygen and pyridine nitrogen. The V atoms in both complexes are in octahedral coordination.

Synthesis, characterization, and insulin-enhancing of vanadium(V) complexes with similar Schiff base ligands

Two new mononuclear vanadium(V) complexes, [VOL1L′] (I) and [VOL2L′] (II), where L1 and L2 are the dianionic form of 2-hydroxy-N′-(4-oxopentan-2-ylidene)benzohydrazide and 4-bromo-N′-(4-oxo-pentan-2-ylidene)benzohydrazide, respectively, and L′ is 8-hydroxyquinoline, have been prepared. The complexes have been characterized by physico-chemical methods and single crystal X-ray determination (CIF files CCDC nos. 1044151 (I) and 1044152 (II)). The V atoms in both complexes are coordinated by the three donor atoms of L, two donor atoms of L′, and one oxo group, forming octahedral coordination. Insulinmimetic tests on C2C12 muscle cells using biovision glucose assay indicates that the complexes significantly stimulated cell glucose utilization with cytotoxicity at 0.10 g L–1.

Characterization and Crystal Structures of Oxovanadium(V) Complexes Derived from N′-(2-Hydroxybenzylidene)Pivalohydrazide

Two new oxovanadium(V) complexes [VOLL1] (1) and [VOLL2] (2) are prepared by the reaction of N′-(2-hydroxybenzylidene)pivalohydrazide (H2L) and [VO(acac)2] (where acac = acetylacetonate) with maltol (HL1) and 8-hydroxyquinoline (HL2), respectively, in methanol. Crystal and molecular structures of the complexes are determined by elemental analysis, infrared and electronic spectra, 1H NMR spectra, and single crystal X-ray diffraction. Complex 1 crystallizes in the monoclinic space group C2/c, with unit cell dimensions a = 15.828(2) Å, b = 22.412(3) Å, c = 12.873(3) Å, β = 121.256(5)°, V = 3903.7(12) Å3, Z = 8, GOOF = 1.036, R1 = 0.0554 and wR2 = 0.1302. Complex 2 crystallizes in the monoclinic space group P21/n, with unit cell dimensions a = 11.995(2) Å, b = 8.700(2) Å, c = 19.466(3) Å, β = 96.497(3)°, V = 2018.3(6) Å3, Z = 4, GOOF = 1.004, R1 = 0.0449 and wR2 = 0.0937. The V atoms are in the octahedral coordination.

Synthesis, Characterization and Crystal Structure of Oxovanadium(V) Complex Derived From 2-Bromo-4-chloro-6-((2-(ethylamino)ethylimino)methyl)phenol

A new centrosymmetric dinuclear oxovanadium(V) complex, [V2O2(μ-O)2L2], was prepared by the reaction of [VO(acac)2] (where acac = acetylacetonate) with the Schiff base ligand 2-bromo-4-chloro-6-((2-(ethylamino)ethylimino)methyl)phenol (HL) in methanol. Crystal and molecular structure of the complex were determined by elemental analysis, infrared and 1H NMR spectra and single-crystal X-ray diffraction. The V···V distance is 3.105(1) Å. The V atoms in the complex are in octahedral coordination, with the phenolate oxygen, imino nitrogen, and amino oxygen of the Schiff base ligand, and one bridging oxo oxygen in the equatorial plane, and with one oxo oxygen and one bridging oxo oxygen in the two axial positions. Thermal stability of the complex was studied.

8-hydroxyquinoline coordinated vanadium(V) complexes with Schiff bases: Synthesis, characterization, and crystal structures

Two new 8-hydroxyquinoline coordinated vanadium(V) complexes, [VO(L1)(L′)] (I) and [VO(L2)(L′)] (II), where L1 is the dianionic form of 2-[(2-hydroxyethylimino)methyl]-6-methylphenol (H2L1), L2 is the dianionic form of N′-(4-oxopentan-2-ylidene)pivalohydrazide (H2L2), L′ is the monoanionic form of 8-hydroxyquinoline (HL′), were prepared and characterized by elemental analysis, infrared, UV-Vis and 1H NMR spectra, and single crystal X-ray diffraction (CIF files CCDC nos. 1012078 (I) and 1012077 (II)). Complex I crystallizes in the monoclinic space group P21/n with unit cell dimensions a = 16.120(1), b = 6.9952(5), c = 16.128(1) Å, β = 106.948(2)°, V = 1739.6(2) Å3, Z = 4, GOOF = 1.127, R1 = 0.0464 and wR2 = 0.1172. Complex II crystallizes in the orthorhombic space group Pna21 with unit cell dimensions a = 13.512(2), b = 9.606(1), c = 31.081(4) Å, V = 4034.3(8) Å3, Z = 8, GOOF = 1.044, R1 = 0.0604 and wR2 = 0.1038. The V atoms in the complexes are in octahedral coordination. Thermal stability of the complexes was studied.

Syntheses, characterization, and structures of vanadium(V) complexes with similar tridentate hydrazone and bidentate benzohydroxamate ligands

New vanadium(V) complexes, [VO(L1)(Bzh)] and [VO(L2)(Bzh)] · CH3OH, were prepared by the reaction of [VO(Acac)2] (Acac = acetylacetonate) and benzohydroxamic acid (HBzh) with N′-(3-bromo-2-hydroxybenzylidene)-2-chlorobenzohydrazide (H2L1) and 2-chloro-N′-(2-hydroxy-5-methoxybenzylidene)benzohydrazide (H2L2), respectively, in methanol. Molecular component and structures of the complexes were determined by elemental analysis, infrared and UV-Vis spectra. Single crystal structures of the complexes were determined by X-ray diffraction (CIF file CCDC nos. 1006633 (I) and 1006634 (II)). The V atoms are in octahedral coordination. Thermal stability of the complexes was studied.

Urease inhibition of oxovanadium(V) complexes with hydrazone and hydroxamate ligands

Two new oxovanadium(V) complexes, [VOL1(SHA)] (I) and [VOL2(BHA)] (II), were prepared by the reaction of [VO(Acac)2] (Acac = acetylacetonate) with N′-(2-hydroxybenzylidene)isonicotinohydrazide (H2L1) and salicylhydroxamic acid (HSHA) and 4-chloro-N′-(2-hydroxy-3-methoxybenzylidene)benzohydrazide (H2L2) and benzohydroxamic acid (HBHA), respectively, in methanol. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared spectra and single crystal X-ray diffraction (CIF file CCDC nos. 978238 (I) and 978392 (II)). The V atoms are in octahedral coordination. Thermal stability and the inhibition of urease of the complexes were studied.

Synthesis, characterization, and X-ray crystal structures of oxovanadium(V) complexes with hydrazone and 8-hydroxyquinoline ligands

Three new oxovanadium(V) complexes with the general formula [VO(L)n(HQ)] (n = 1–3) were prepared by the reaction of [VO(Acac)2] (Acac = acetylacetonate) and 8-hydroxyquinoline with similar benzohydrazide ligands in methanol. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared and UV-Vis spectra and single crystal X-ray diffraction (CIF file CCDC nos. 1004087 (I), 1004088 (II), and 1004089 (III)). The V atoms are in octahedral coordination. Thermal stability of the complexes were studied.