Yuan W

Study on TP53 codon 72 polymorphisms with oral carcinoma susceptibility.

BACKGROUND AND AIMS Previous published data have implicated TP53 codon 72 polymorphisms as risk factors for various cancers. Growing bodies of studies have been conducted on the association of TP53 codon 72 polymorphisms with susceptibility to oral carcinoma and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of this relationship. METHODS We conducted a search in the relevant databases without a language limitation, covering all papers published until May 2009. The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications. RESULTS Nine studies including 1990 cases and 2074 controls were selected. Data were extracted and further analyzed using systematic meta-analyses. Results showed that no significant differences of oral cancer risk were found between individuals carrying homozygote Arg/Arg genotype and those carrying Pro/Pro genotype (OR: 0.96, 95% CI: 0.78-1.19). Likewise, no evidence indicated that individuals with Arg/Arg genotype have a significant risk of oral cancer compared with those with a combined Pro genotype (Arg/Pro+Pro/Pro) (OR: 0.98, 95% CI: 0.85-1.12). Similarly, individuals with a combined Arg genotype (Arg/Pro+Arg/Arg) do not have a marked increased or decreased susceptibility to oral cancer relative to those with homozygote Pro/Pro genotype (OR: 1.00, 95% CI: 0.83-1.21). Moreover, when stratifying for race, results were similar among Asians or Caucasians. In addition, TP53 codon 72 polymorphisms may not associate with oral cancer risks in smokers and HPV infection status. CONCLUSIONS No evidence suggests that TP53 codon 72 polymorphisms may be a risk factor for oral carcinoma.

Long-term improvements in quality of life after functional endoscopic sinus surgery for adolescents with chronic rhinosinusitis

Abstract Conclusions: The long-term quality of life of adolescents with chronic rhinosinusitis improved significantly after functional endoscopic sinus surgery (FESS), and endoscopic sinus surgery showed certain benefits for adolescent patients. The selection of appropriate patients may further improve the surgical outcomes and quality of life. Objective: To analyze the long-term quality of life in adolescents (12–18 years) with chronic rhinosinusitis after endoscopic sinus surgery, and to evaluate the value of endoscopic sinus surgery in adolescent patients. Methods: From 2003 to 2008, 729 adolescents with chronic sinusitis underwent endoscopic sinus surgery in our department; 270 of these patients were included in the study. Their quality of life was assessed before and within 3–8 years after the surgery using the SNOT-20 scale and was compared with that of healthy individuals of the same age. Results: The SNOT-20-based assessment showed that the overall quality of life differed significantly before and after surgery (p = 0.000) and that some symptoms (dizziness, sense of facial oppression, sleep difficulty, embarrassment, and fatigue) had no significant differences before and after surgery (p > 0.05). Preoperative and postoperative symptoms (dizziness, sense of facial oppression, sleep difficulty, embarrassment, and fatigue) showed no significant differences between the healthy population and treated patients (p > 0.05).

Osteoma of Stapes in the Middle Ear: A Case Report

Middle ear osteoma is a rare benign tumor. Twenty-five cases of middle ear osteoma have been reported in the literature, consisting mostly of osteomas of the malleus and incus; osteomas of the stapes are rare. Indeed, there has been only 1 report of conductive hearing loss caused by an osteoma on the boundary between the facial nerve canal and the stapes footplate (1). The following is a case report on a patient with an osteoma of the stapes who was treated in our clinic.