Yuansheng Gao
University of California, Berkeley
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Featured researches published by Yuansheng Gao.
Pediatric Research | 1998
Yuansheng Gao; Jean Francois Tolsa; J. Usha Raj
Endothelium-derived nitric oxide (EDNO) plays a pivotal role in regulating pulmonary circulation. To determine whether there is a heterogeneity in EDNO-mediated responses of different sized pulmonary vessels, we studied small and large isolated pulmonary arteries of newborn lambs (diameter, 0.4-0.7 and 1.5-2.5 mm, respectively). The isometric tension of vessel rings were recorded while suspended in organ chambers filled with modified Krebs-Ringer bicarbonate solution (95% O2-5% CO2, 37°C). In vessels preconstricted with norepinephrine, acetylcholine and bradykinin induced a greater relaxation of small pulmonary arteries than of large pulmonary arteries. Acetylcholine, bradykinin, and nitric oxide also induced a greater increase in cGMP content in small arteries than in large ones. The responses to acetylcholine and bradykinin were endothelium-dependent and inhibited by nitro-L-arginine, an inhibitor of nitric oxide synthase. In vessels without endothelium, the response to nitric oxide was inhibited by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, an inhibitor of soluble guanylate cyclase. The activity of soluble guanylyl cyclase of small arteries was greater than that of large arteries under basal conditions and after stimulation with S-nitroso-N-acetylpenicillamine, a nitric oxide donor. These results demonstrate that heterogeneity exists in EDNO-mediated relaxation of small and large pulmonary arteries in newborn lambs. A difference in the soluble guanylate cyclase activity of vascular smooth muscle may have contributed to this phenomenon.
Journal of Applied Physiology | 2000
Srinivas Dhanakoti; Yuansheng Gao; Minh Q. Nguyen; J. Usha Raj
Journal of Applied Physiology | 1996
Yuansheng Gao; Haiyan Zhou; Basil O. Ibe; J. Usha Raj
Journal of Applied Physiology | 1999
Jean Francois Tolsa; Yuansheng Gao; J. Usha Raj
Fetal and Neonatal Physiology (Fifth Edition) | 2017
Yuansheng Gao; J. Usha Raj
Archive | 2016
Yuansheng Gao; J. Usha Raj
Archive | 2015
Candice D. Fike; Mark R. Kaplowitz; Yongmei Zhang; Sandra L. Pfister; Bernard Muller; Estelle Delannoy; Arnaud Courtois; Véronique Freund-Michel; Véronique Leblais; Yuansheng Gao; J. Usha Raj
Archive | 2015
Candice D. Fike; Mark R. Kaplowitz; Leif D. Nelin; Wei Wei; Da-De Huang; Wei Luo; Dan Luo; Zhi-Ping Wang; Xi Zhang; Yuansheng Gao; J. Usha Raj
Archive | 2015
Jaques Belik; R. P. Jankov; Jingyi Pan; M. Yi; I. Chaudhry; A. K. Tanswell; Yuansheng Gao; J. Usha Raj; Bobby Mathew; Sylvia F. Gugino; James A. Russell; Daniel D. Swartz; Satyan Lakshminrusimha; Robin H. Steinhorn; Stephen Wedgwood; Fabio Savorgnan; Y. S. Prakash; Christina M. Pabelick; Bharathi Aravamudan; Michael A. Thompson; Yassine Amrani; Hitesh Pandya; R. Hartman; Dan F. Smelter; Michael Karass; Sunchin Kim
Archive | 2015
Yuansheng Gao; Srinivas Dhanakoti; J. Usha Raj; Huijuan Ma; Qiong He; Dou Dou; Xiaoxu Zheng; Lei Ying; Yuming Wu