Yuhei Tahara
Osaka City University
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Publication
Featured researches published by Yuhei Tahara.
Nature Communications | 2017
Marie Trussart; Eva Yus; Sira Martínez; Davide Baù; Yuhei Tahara; Thomas Pengo; Michael Widjaja; Simon Kretschmer; Jim Swoger; Steven P. Djordjevic; Lynne Turnbull; Cynthia B. Whitchurch; Makoto Miyata; Marc A. Marti-Renom; Maria Lluch-Senar; Luis Serrano
DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of such bacteria adopt defined three-dimensional structures remains unexplored. Here we combine Hi-C and super-resolution microscopy to determine the structure of the Mycoplasma pneumoniae chromosome at a 10 kb resolution. We find a defined structure, with a global symmetry between two arms that connect opposite poles, one bearing the chromosomal Ori and the other the midpoint. Analysis of local structures at a 3 kb resolution indicates that the chromosome is organized into domains ranging from 15 to 33 kb. We provide evidence that genes within the same domain tend to be co-regulated, suggesting that chromosome organization influences transcriptional regulation, and that supercoiling regulates local organization. This study extends the current understanding of bacterial genome organization and demonstrates that a defined chromosomal structure is a universal feature of living systems.
Bulletin of the Chemical Society of Japan | 2017
Takuya Sagami; Shota Umemoto; Yuhei Tahara; Makoto Miyata; Yusuke Yonamine; Daisuke Ishikawa; Taizo Mori; Katsuhiko Ariga; Hiroyuki Miyake; Satoshi Shinoda
Chemical Communications | 2017
Takuya Sagami; Yuhei Tahara; Makoto Miyata; Hiroyuki Miyake; Satoshi Shinoda
Journal of Electron Microscopy | 2018
Kohei Kobayashi; Noriyuki Kodera; Yuhei Tahara; Takuma Toyonaga; Taishi Kasai; Toshio Ando; Makoto Miyata
Journal of Bacteriology | 2016
Yoshito Kawakita; Miki Kinoshita; Yukio Furukawa; Isil Tulum; Yuhei Tahara; Eisaku Katayama; Keiichi Namba; Makoto Miyata
Journal of Electron Microscopy | 2015
Wu Zhe Feng; Yuhei Tahara; Eisaku Katayama; Makoto Miyata
Journal of Electron Microscopy | 2015
Yuhei Tahara; Kana Fukunishi; Eisaku Katayama; Taro Nakamura; Chikashi Shimoda; Makoto Miyata
Journal of Electron Microscopy | 2015
Peng Liu; Qingguo Meng; Wei Gu; Wen Wang; Yuhei Tahara; Makoto Miyata
Journal of Electron Microscopy | 2015
Daiki Matsuike; Yuhei Tahara; Tasuku Hamaguchi; Makoto Miyata
Journal of Electron Microscopy | 2015
Clothilde Bertin; Yuhei Tahara; Eisaku Katayama; Makoto Miyata