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Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Yuichiro Kai.
Bioorganic & Medicinal Chemistry Letters | 2008
Masahiko Uchida; Kosuke Okazaki; Harunobu Mukaiyama; Hidetoshi Isawa; Hiroaki Kobayashi; Hiroaki Shiohara; Hideyuki Muranaka; Yuichiro Kai; Norihiko Kikuchi; Hideki Takeuchi; Kenji Yokoyama; Eiichi Tsuji; Tomonaga Ozawa; Yuji Hoyano; Takashi Koizumi; Keiko Misawa; Kiyoto Hara; Shigeru Nakano; Yasuoki Murakami; Hiroaki Okuno
A series of novel and potent 3-amidinophenylsulfonamide derivatives of factor Xa inhibitors were designed and synthesized using an amidoxime prodrug strategy. We focused on systemic clearance of parent compounds in rats, and performed in vivo pharmacokinetic screening. Incorporation of a carboxymethoxy group markedly improved systemic clearance (compound 43), and the related amidoxime 44 showed sufficient prodrug conversion. Compound 45, the double prodrug of 43, exhibited practicable bioavailability after oral administration in rats. Among the various compounds under investigation, KFA-1982 was selected for clinical development.
Archive | 1998
Satoshi Akahane; Masahiko Uchida; Hideotoshi Isawa; Norihiko Kikuchi; Tomonaga Ozawa; Hiroaki Kobayashi; Yuichiro Kai; Kenji Akahane
Archive | 2004
Junichi Kobayashi; Tetsuya Nakamura; Ritsu Suzuki; Hideyuki Kissei Pharmaceutical Co. Ltd. Muranaka; Tomonaga Ozawa; Yuichiro Kai; Takehiro Ishikawa; Tatsuhiro Kondo; Tetsuro Kissei Pharmaceutical Co. Ltd. Tamai; Satoshi Akahane
Archive | 2001
Kosuke Okazaki; Masahiko Uchida; Harunobu Mukaiyama; Hiroaki Kobayashi; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Yuji Hoyano; Hiroaki Shiohara; Norihiko Kikuchi
Archive | 2002
Masahiko Uchida; Hiroaki Kobayashi; Yuichiro Kai; Kenji Yokoyama; Yoshihiro Terao; Hideyuki Muranaka
Archive | 2000
Satoshi Akahane; Masahiko Uchida; Hidetoshi Isawa; Norihiko Kikuchi; Yuichiro Kai; Kiyoto Hara; Toshiki Honma
Archive | 2002
Kosuke Okazaki; Masahiko Uchida; Hiroaki Kobayashi; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Ritsu Suzuki
Organic Process Research & Development | 2012
Hideki Takeuchi; Koji Kamata; Eiichi Tsuji; Harunobu Mukaiyama; Yuichiro Kai; Kenji Yokoyama; Kazumichi Jo; Katsuhide Terada
Archive | 2003
Harunobu Mukaiyama; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Satoshi Akahane
Archive | 2002
Kosuke Okazaki; Masahiko Uchida; Hiroaki Kobayashi; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Ritsu Suzuki
