Yuka Noborisaka

Impact of obesity on musculoskeletal pain and difficulty of daily movements in Japanese middle-aged women.

OBJECTIVE To investigate the impact of obesity on musculoskeletal pain and disability, which impairs well-being, associations between body mass index (BMI), frequency of musculoskeletal pain and difficulty of daily movements were assessed in middle-aged women. METHODS Subjects were 709 Japanese women in a community, aged 40-69. Measured BMI, current smoking habits, frequency of pain (pain score)(rarely (0), occasionally (1) or frequently (2)) during the last 1 month at shoulders, neck, upper back, lower back and legs, difficulty of three daily movements: walking continually for more than a half hour, climbing stairs and sitting on the floor with ones legs bent beneath one another, (score for each movement) (rarely (0), occasionally (1) or frequently (2)) by a questionnaire. The summed score was defined as the difficulty score of daily movements (DS) (0-6). RESULTS BMI increased significantly with age. Lower back pain (occasionally or frequently) was the most common symptom (40.3%) in the subjects. There was a peak in prevalence of frequent pain of shoulders at age 50. Pain score for legs and DS increased significantly with age. Higher BMI was related to increased prevalence of frequent leg pain and DS (>or=3), but there were no significant associations between age or BMI, and scores of back pain. DS was correlated significantly with pain scores at shoulders, upper back, lower back and legs. After adjustment for age and smoking habit using a logistic regression analysis, odds ratios for frequent pain at legs and DS (>or=3) were 4.02 (CI: 1.83-8.80) and 2.92 (CI: 1.56-5.47), respectively, in the obese women (BMI>or=26.4, n=61), compared with 401 women with normal BMI (20-24). CONCLUSION Obesity tended to impair well-being through musculoskeletal pain at legs and difficulty of daily movements in Japanese middle-aged women.

Urinary cadmium excretion is correlated with calcaneal bone mass in Japanese women living in an urban area.

Nine hundred eight women aged 40-88 years living in a non-Cd-polluted area in Japan were analyzed for urinary cadmium (Cd), N-acetyl-beta-D-glucosaminidase (NAG) activity, beta(2)-microglobulin (B2MG) concentration, and for the stiffness index (STIFF) of calcaneal bone using an ultrasound method. The urinary Cd in the subjects, with a mean and range of 2.87 and 0.25-11.4 microg/g creatinine, respectively, showed a significant correlation with NAG but not with B2MG. STIFF was significantly inversely correlated with urinary Cd, and the association remained significant after adjusting for age, body weight, and menstrual status, suggesting a significant effect of Cd on the bone loss in these subjects without signs of Cd-induced kidney damage. A two-fold increase in urinary Cd was accompanied by a decrease in STIFF corresponding to a 1.7-year rise in age. These results emphasize the need for reassessment of the significance of Cd exposure in the general Japanese population.

Relationship between job stress and plasma fibrinolytic activity in male Japanese workers.

Psychosocial job stress has been shown to be associated with the development of cardiovascular disease. However, the pathophysiological mechanisms underlying this relationship remain unclear. The aim of the present study was to elucidate whether marked job stress affects the parameters of blood coagulation and fibrinolysis, such as plasma fibrinogen concentration, tissue plasminogen activator (t-PA), and plasminogen activator inhibitor 1 (PAI-1) activities, in 213 middle-aged male workers in a computer-producing factory. Job stress was measured using a Japanese version of the Job Content Questionnaire (JCQ) developed by Karasek. The mean t-PA activity in workers with lower and higher job demands was 0.23 and 0.18 IU/ml respectively, and this difference was significant (P < 0.05). The mean plasma fibrinogen in workers with lower and higher job decision latitude was 224.8 and 236.3 mg/dl respectively, and the mean PAI-1 activity in workers with lower and higher job strain was 14.9 and 17.7 U/ml respectively, though these differences remained at a borderline level of significance (0.05 < P < 0.10). Multiple regression analyses showed that the parameters of blood coagulation and fibrinolysis were closely associated with the cardiovascular risk factors of age, obesity, blood pressure, elevated serum lipids, and smoking, but that high job demands were significantly related to decreases in t-PA activity, independently of the traditional risk factors. These results suggest that psychosocial job stress may be related, at least partly, to the development of cardiovascular disease via changes in plasma fibrinolytic activity.

Smoking and chronic kidney disease in healthy populations.

The objective of this review is to explore the link between smoking and the development of chronic kidney disease (CKD) in generally healthy populations without pre-existing renal dysfunction such as diabetic nephropathy. Twenty-eight epidemiological studies concerning the renal effects of smoking in the general population were collected from the MEDLINE database and were reviewed for indications of proteinuria and/or the decline of glomerular filtration rate (GFR), and evaluated on the level of evidence and the quality of the study. Sixteen of the 28 studies were cross-sectional in design. Most articles had some weakness in scope, such as the 6 articles which did not fully exclude DM patients from the subjects, the 4 that did not consider the effects of ex-smoking, and the 3 that focused on only a small number of subjects. From these cases, it is difficult to draw firm conclusions. However, proteinuria or microalbuminuria was persistently high in current smokers; as much as 5-8% or 8-15% respectively, which was up to 2 to 3-times the rate of lifelong non-smokers. On the other hand, only 5 studies broader in scope detected any decline of GFR in smokers, while 9 other studies suggested a higher GFR in smokers than in non-smokers. Two good quality studies showed an even a significantly lower risk of a decreased GFR in smokers. These paradoxical CKD markers in smokers, i.e., a higher appearance of proteinuria with a higher GFR, could be a focus for further studies to reveal the underlying reasons for smoking-induced CKD. Workplaces may be an excellent place to study this subject since the long-term changes in renal function of smokers can be observed by collecting data in the annual health check-ups mandated at places of employment.

Alcohol consumption, serum gamma-glutamyltransferase levels, and coronary risk factors in a middle-aged occupational population.

Alcohol Consumption, Serum gamma‐Glutamyltransferase Levels, and Coronary Risk Factors in a Middle‐Aged Occupational Population: Yuichi Yamada, et al. Department of Hygiene, Kanazawa Medical University—The relationships between alcohol consumption, serum gamma‐glutamyltransferase (GGT) levels, and the prevalence of major coronary risk factors were analyzed crosssectionally in 2,399 male and 1,402 female middle‐aged workers, to clarify the effects of moderate alcohol consumption on the development of the metabolic syndrome. Male moderate drinkers, consuming less than 60 ml of alcohol per day, had a lower prevalence of upper body obesity and low serum HDL‐cholesterolemia (LHDLC) in comparison with nondrinkers, but not of hypertension, impaired glucose tolerance or hypertriglyceridemia (HTG). In women, alcohol consumption did not show any significant associations with the coronary risk factors. Men with an elevated serum GGT (EGGT) of 40 U/l or above had a significantly higher odds ratio for all the coronary risk factors as compared with those with normal GGT, even after adjusting for alcohol consumption, together with age, body mass index, cigarette consumption and physical activity. Women with an EGGT of 25 U/l or above had similar findings, although significance was found only in HTG. Nearly 80% and 55% of the appearance of EGGT in men and women were attributable to alcohol consumption, and 20% and 10% of the male and female moderate drinkers had EGGT. These results suggest that even moderate alcohol consumption will increase coronary risk factors characteristic of the metabolic syndrome in drinkers who have an increase in serum GGT. Further studies are required to confirm the causal association between alcohol consumption, increase in serum GGT and development of the metabolic syndrome.

Cardiovascular and muscle activity during chewing in whiplash-associated disorders (WAD)

OBJECTIVE The present study aimed to elucidate possible physiological mechanisms behind impaired endurance during chewing as previously reported in WAD. We tested the hypothesis of a stronger autonomic reaction in WAD than in healthy subjects in response to dynamic loading of the jaw-neck motor system. DESIGN Cardiovascular reactivity, muscle fatigue indicies of EMG, and perceptions of fatigue, exhaustion and pain were assessed during standardised chewing. Twenty-one WAD subjects and a gender/age matched control group participated. Baseline recordings were followed by two sessions of alternating unilateral chewing of a bolus of gum with each session followed by a rest period. RESULTS More than half of the WAD subjects terminated the test prematurely due to exhaustion and pain. In line with our hypothesis the chewing evoked an increased autonomic response in WAD exhibited as a higher increase in heart rate as compared to controls. Furthermore, we saw consistently higher values of arterial blood pressure for WAD than for controls across all stages of the experiment. Masseter EMG did not indicate muscle fatigue nor were there group differences in amplitude and mean power frequency. Pain in the WAD group increased during the first session and remained increased, whereas no pain was reported for the controls. CONCLUSION More intense response to chewing in WAD might indicate pronounced vulnerability to dynamic loading of the jaw-neck motor system with increased autonomic reactivity to the test. Premature termination and autonomic involvement without EMG signs of muscle fatigue may indicate central mechanisms behind insufficient endurance during chewing.

Alcohol consumption, homeostasis model assessment indices and blood pressure in middle-aged healthy men

A total of 1595 middle-aged healthy men consuming alcohol up to 120 ml per day and 538 without alcohol consumption were recruited from an occupational population, and their insulin resistance (IR) and beta-cell function (BC) were measured using the homeostasis model assessment (HOMA-IR and HOMA-BC), and the associations with alcohol consumption, blood pressure (BP), and serum gamma-glutamyltransferase (GGT) levels were analysed cross-sectionally. Both HOMA-IR and HOMA-BC were decreased with increasing alcohol consumption, but HOMA-BC corresponding to a level of HOMA-IR was 4–10 and 8–20% lower in drinkers consuming less than 60 ml of alcohol per day and those consuming more, respectively, than in nondrinkers, suggesting an altered fasting serum insulin–glucose relationship in alcohol consumers. Although BP was higher and HOMA-IR was lower in alcohol consumers than in nonconsumers, BP was higher at higher HOMA-IR irrespective of alcohol consumption. Elevations of serum GGT were positively associated with BP and HOMA-IR in both alcohol consumers and nonconsumers. Multiple regression analyses in the subjects showed that elevated serum GGT was an independent contributor to HOMA-IR elevations, and both serum GGT and HOMA-IR were significantly related to BP elevations after adjusting for alcohol consumption, age, body mass index, cigarette consumption, and physical activity at leisure. Although cross-sectional observations do not provide evidence of causal association, the results suggest that elevated serum GGT in alcohol consumers relates to elevations of IR and that the elevated insulin resistance relates, at least partly, to BP elevations in alcohol consumers.

Serum γ-Glutamyl Transferase Levels and Blood Pressure Falls After Alcohol Moderation

Drinkers showing higher serum γ-glutamyl transferase (GGT) levels tend to have higher blood pressure (BP), independent of the volume of alcohol consumed. To further evaluate the link between alcohol consumption and elevated serum GGT and BP, we observed BP, serum biochemical parameters, plasma pressor hormones and intraplatelet free calcium (P < [Ca2+] i) in 40 moderate drinkers who were composed of four categories of 10 each with or without hypertension (≥140/90 mmHg) or high serum GGT level (≥50 U/L) during four-week alcohol moderation. BP and serum hepatic enzymes including GGT decreased more conspicuously in both normotensive and hypertensive drinkers with high serum GGT. Serum triglyceride was higher and potassium was lower in the drinkers with high serum GGT, and were normalized during alcohol moderation. Serum calcium, P < [Ca2+li and plasmareninactivity and cortisol showed some decreases during alcohol moderation,but were not different in the drinkers with different serum GGT and BP levels. No sig...

Association between Cigarette Consumption and Proteinuria in Healthy Japanese Men and Women from an Occupational Population

Association between Cigarette Consumption and Proteinuria in Healthy Japanese Men and Women from an Occupational Population: Yuichi Yamada, et al. Department of Social and Environmental Medicine (Hygiene), Kanazawa Medical University—The association between cigarette consumption and prevalence of mild proteinuria (30–99 mg/dl of albumin) was analyzed in 11,569 male and 4,715 female workers aged 18–67 yr recruited from an occupational population. Proteinuria was found in 274 (2.4%) of the total male workers and in 50 (1.1%) of the total females. Stepwise logistic regression analyses showed that sex, suspected diabetes mellitus, blood pressure (BP) and Brinkman Index (BI) levels (0, 1–199, 200–499, 500–799, 800–) were significantly related to proteinuria, and that the odds ratio of each BI level for proteinuria was 1.11 (C.I.: 1.01–1.67). In the subjects aged 50 yr or older, after excluding those suspected of having hypertension and/ or diabetes mellitus, the odds ratio reached 1.37 (C.I.: 1.15–1.63), with the gender difference then no longer significant. The odds ratio for proteinuria was calculated as 5.44 (C.I.: 2.27–13.0) in male and female smokers having a BI of 500 or above and normal‐high BP (130–139/85–89 mmHg) in comparison with nonsmokers having normal BP (<130/85 mmHg). These results suggest that heavy cigarette consumption represented by a BI of 500 or above is a risk factor of proteinuria even in healthy Japanese workers, particularly in those aged 50 yr or older and having normal‐high BP.

Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men.

Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men