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Featured researches published by Yuki Iwabuchi.


international conference on biomedical engineering | 2014

Relationship between Pathology and Hemodynamics of Human Unruptured Cerebral Aneurysms

Yasutaka Tobe; Takanobu Yagi; Yuki Iwabuchi; Momoko Yamanashi; Kenji Takamura; Takuma Sugiura; Mitsuo Umezu; Yoshifumi Hayashi; Hirotaka Yoshida; Atsushi Nakajima; Kazutoshi Nishitani; Yoshifumi Okada; Michihito Sugawara; Shin Hiraguchi; Toshiro Kubo; Shigemi Kitahara

This research compared the intraoperative appearance, computational fluid dynamic (CFD) analysis, and scanning electron microscope (SEM) observation of endothelial cells (EC) of seven human cerebral aneurysms in an effort to find the relationship between hemodynamic patterns and wall-thinning of aneurysms.


Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments | 2013

Combined analysis of pathology and hemodynamics of human unruptured cerebral aneurysm with thin-walled region

Yasutaka Tobe; Takanobu Yagi; Yuki Iwabuchi; Momoko Yamanashi; Kenji Takamura; Kiyotaka Iwasaki; Mitsuo Umezu; Yoshifumi Hayashi; Hirotaka Yoshida; Atsushi Nakajima; Kazutoshi Nishitani; Yoshifumi Okada; Michihito Sugawara; Shin Hiraguchi; Toshiro Kubo; Shigemi Kitahara

Cerebral aneurysms are known as the top reason of subarachnoid hemorrhage (SAH). They are studied in the medical and the engineering field to reveal their pathogenesis, progression, and rupture mechanisms1,2. The pathological studies revealed the site of predilection, rupture rate, the risk factors1, inflammation within the aneurysm, and conditions of endothelial cells (EC) in the aneurysms3. The current pathological analyses of the cerebral aneurysms are all phenomenological and it does not consider the cause-and-effect mechanisms between the mechanical stimulation and the physiological effect although hemodynamics is thought to play an important role in the mechanisms of aneurysms. One reason that the aneurysms’ mechanisms remain unsolved is because the pathology and hemodynamics are studied independently. Purpose of this study is to reveal the relationship of endothelial cell, thickness, and hemodynamics of the cerebral aneurysms by comparing the scanning electron microscope (SEM) analyses, μCT, and the computational fluid dynamics (CFD) analyses of the cerebral aneurysms.© 2013 ASME


ASME 2012 Summer Bioengineering Conference, Parts A and B | 2012

Investigation on a Relationship Between Hemodynamics and Wall-Thinning in an Unruptured Human Cerebral Aneurysm

Yasutaka Tobe; Takanobu Yagi; Sara Takahashi; Yuki Iwabuchi; Momoko Yamanashi; Kiyotaka Iwasaki; Mitsuo Umezu; Yoshifumi Hayashi; Hirotaka Yoshida; Kazutoshi Nishitani; Yoshifumi Okada; Michihito Sugawara; Shin Hiraguchi; Toshiro Kubo; Shigemi Kitahara

Recent studies of cerebral aneurysms are held using the blood flow simulation with patient-specific luminal geometries. In the study of development of cerebral aneurysms, wall shear stress (WSS) is focused as one of the key factors1–2. But the answer to the relationship between the extension of aneurysm and the theory of low WSS and high WSS still remains a question. One reason this question remains unsolved is because the current research about the cerebral aneurysms are held only using the vascular geometry developed from the medical images. From the intra-operative observation of cerebral aneurysms, the appearance of the cerebral aneurysm is not unified. Certain parts of the cerebral aneurysm have thin-walled structures where the blood flow of the aneurysm can be observed through the aneurysm wall. These differences in the wall structures cannot be predicted from the medical images. The purpose of this study is to see the relationship between hemodynamic patterns and thin-walled structure in human cerebral aneurysms.Copyright


The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME | 2014

1G12 Study of hemodynamics and wall thinning of branch vessel is initiation of cerebral aneurysms

Yuki Iwabuchi; Takanobu Yagi; Yasutaka Tobe; Mitsuo Umezu; Yoshifumi Hayashi; Hirotaka Yoshida; Kazutoshi Nishitani; Yoshifumi Okada; Shigemi Kitahara


The Proceedings of the JSME Conference on Frontiers in Bioengineering | 2013

A219 ヒト未破裂脳動脈瘤の瘤壁の菲薄化を術前に検知できる血流の指標化に関する検討(A2-4 循環器系バイオメカニクス2)

Yuki Iwabuchi; Takanobu Yagi; Yasutaka Tobe; Mitsuo Umezu; Yoshifumi Hayashi; Hirotaka Yoshida; Kazutoshi Nishitani; Yoshifumi Okada; Shigemi Kitahara


The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME | 2013

3C02 Development of blood flow diagnostics for pre-operative prediction of wall thinning of cerebral aneurysms

Takanobu Yagi; Yasutaka Tobe; Yuki Iwabuchi; Momoko Yamanashi; Kenji Takamura; Kiyotaka Iwasaki; Mitsuo Umezu; Yoshihumi Hayashi; Yoshihumi Okada; Hirotaka Yoshida; Sigemi Kitahara


The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME | 2013

3C03 Hemodynamic and pathological analysis of wall thinning effect of human cerebral aneurysms

Yasutaka Tobe; Takanobu Yagi; Yuki Iwabuchi; Momoko Yamanashi; Kenji Takanobu; Kiyotaka Iwasaki; Mitsuo Umezu; Yoshifumi Hayashi; Yoshifumi Okada; Hirotaka Yoshida; Shigemi Kitahara


Stroke | 2013

Abstract TMP29: Prediction of Wall-thinning Area in Unruptured Intracerebral Aneurysms by Computational Fluid Dynamics

Yoshifumi Hayashi; Takanobu Yagi; Yasutaka Tobe; Yuki Iwabuchi; Momoko Yamanashi; Kenji Takamura; Kiyotaka Iwasaki; Mitsuo Umezu; Takashi Ishida; Atsushi Nakajima; Hirotaka Yoshida; Kazutoshi Nishitani; Yoshihisa Ota; Michihito Sugawara; Yoshifumi Okada; Toshiro Kubo; Shigemi Kitahara


The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME | 2012

8F47 Investigation on a wall-thinning mechanism of human cerebral aneurysms by comparing their hemodynamics and intra-operative observation

Yasutaka Tobe; Sara Takahashi; Yuki Iwabuchi; Momoko Yamanashi; Kiyotaka Iwasaki; Mitsuo Umezu; Yoshifumi Hayashi; Yoshifumi Okada; Michihito Sugawara; Shigemi Kitahara


The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME | 2012

8F46 Dynamics of flow impingement in cerebral aneurysm by using EFD and CFD

Sara Takahashi; Takanobu Yagi; Yasutaka Tobe; Yuki Iwabuchi; Momoko Yamanashi; Kiyotaka Iwasaki; Mitsuo Umezu; Yuichi Murayama; Hiroyuki Takao

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Hiroyuki Takao

Jikei University School of Medicine

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