Yukihiro Yaginuma
Juntendo University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Yukihiro Yaginuma.
Diagnostic and Therapeutic Endoscopy | 2015
Yuichi Tomiki; Seigo Ono; Jun Aoki; Rina Takahashi; Shun Ishiyama; Kiichi Sugimoto; Yukihiro Yaginuma; Yutaka Kojima; Michitoshi Goto; Atsushi Okuzawa; Kazuhiro Sakamoto
Objective. A new sclerosing agent for hemorrhoids, aluminum potassium sulfate and tannic acid (ALTA), is attracting attention as a curative treatment for internal hemorrhoids without resection. The outcome and safety of ALTA sclerotherapy using an endoscope were investigated in the present study. Materials and Methods. Subjects comprised 83 internal hemorrhoid patients (61 males and 22 females). An endoscope was inserted and retroflexed in the rectum, and a 1st-step injection was applied to the upper parts of the hemorrhoids. The retroflexed scope was returned to the normal position, and 2nd–4th-step injections were applied to the middle and lower parts of the hemorrhoids under direct vision. The effects of endoscopic ALTA sclerotherapy were determined by evaluating the condition of the hemorrhoids using an anoscope and interviewing the patient 28 days after the treatment. Results. A cure, improvement, and failure were observed in 54 (65.1%), 27 (32.5%), and 2 (2.4%) patients, respectively, treated with ALTA. Complications developed in 4 patients (mild fever in 3 and hematuria in 1). Recurrence occurred in 9.6%. Conclusions. The results of the present study suggest that endoscopic ALTA has the potential to become a useful and minimally invasive approach for ALTA sclerotherapy.
Journal of International Medical Research | 2006
Jo Unotoro; Hirohiko Kamiyama; Yasunori Ishido; Yukihiro Yaginuma; Shinji Kasamaki; Kazuhiro Sakamoto; A Oota; Y Ishibashi; Toshiki Kamano
Colorectal cancer is thought to be more common in men than in women. The chromosomal locations of DNA gains and losses in surgical specimens of colorectal tumours were detected by comparative genomic hybridization and were compared by gender. Five chromosomal regions, 7p, 8p, 8q, Xp and Xq, contained multiple gains that were significantly more common in males than in females, and within these regions, the differences were significant for Xp21, Xp11.3, Xp11.4 and Xq26. Regions 1p, 3q, 11q, 12p, 12q and 15q contained multiple sites of gain that were significantly more common in females than in males. Tumours from male and female patients showed significantly more losses at 11p and 15q, and at 4q and Xq, respectively. The fact that gains in X-chromosomal regions were detected with a significantly higher frequency in tumours from male patients suggests that the difference between the genders might be explained by X-chromosomal inactivation.
Journal of International Medical Research | 2006
Yukihiro Yaginuma; Jo Unotoro; Hirohiko Kamiyama; Yasunori Ishido; Shinji Kasamaki; Kazuhiro Sakamoto; Takayuki Shindo; Y Ishibasi; Toshiki Kamano
Lymph-node metastasis is an important indicator in the diagnosis of colon cancer. In order to determine the genes involved in metastasis, genomic copy-number aberrations in the primary tumours and lymph-node metastases were analysed in 12 patients using comparative genomic hybridization. This method detects genomic copy-number changes at the chromosomal level and the identification of the regions of aberration on any chromosome. Copy-number gains at 6p12 and losses at 8p12 were observed in a greater number of the primary tumours than in the metastases. These aberrations appear to be involved in lymph-node metastasis of colon cancer, and may allow measurement of the risk of lymph-node metastasis from a given colon cancer.
Journal of Medical Case Reports | 2014
Makoto Takahashi; Koichiro Niwa; Shun Ishiyama; Kiichi Sugimoto; Hiromitsu Komiyama; Yukihiro Yaginuma; Yutaka Kojima; Michitoshi Goto; Atsushi Okuzawa; Yuichi Tomiki; Kazuhiro Sakamoto
IntroductionTherapy comprising 5-fluorouracil, levofolinate, and oxaliplatin is currently the most common chemotherapy for colorectal cancer. We experienced a successful case of advanced colon cancer and recurrent breast cancer with 5-fluorouracil, levofolinate, and oxaliplatin therapy.Case presentationA 43-year-old Japanese woman who had already undergone surgery three times for bilateral breast cancer was admitted to our hospital for the treatment of advanced transverse colon cancer. Preoperative computed tomography demonstrated a swollen lymph node at her right upper clavicle, and fine-needle aspiration biopsy of the lymph node showed that it was a metastasis from the breast cancer. A laparoscopic-assisted colectomy was performed and the pathology demonstrated that the final stage was IIIC (T4aN2aM0, Union for International Cancer Control, 7th edition). The pathological findings and immunohistochemistry showed that the transverse colon tumor was not a metastatic lesion from the breast cancer, but was a de novo colon cancer. Chemotherapy was necessary for both the recurrent breast cancer and the Stage IIIC colon cancer. Therapy of 5-fluorouracil, levofolinate, and oxaliplatin was administered; the therapy included 5-fluorouracil, which is considered to be effective for both colon and breast cancer. After two courses of 5-fluorouracil, levofolinate, and oxaliplatin, the lymph node began to shrink and almost completely disappeared after eight courses of 5-fluorouracil, levofolinate, and oxaliplatin.ConclusionWe surmise that 5-fluorouracil, levofolinate, and oxaliplatin have the potential to provide a good response for tumors that are sensitive to fluorinated pyrimidine and platinum-containing anticancer drugs such as breast cancer.
Digestive Endoscopy | 2006
Yuichi Tomiki; Koji Shinmura; Shinji Kasamaki; Kiyoshi Terai; Tsutomu Maeda; Ryohei Takeda; Makoto Takahashi; Yukihiro Yaginuma; Kazuhiro Sakamoto; Takashi Nakajima; Toshiki Kamano; Yasuo Hayashida
Background: Respiratory suppression is observed during endoscopy under sedation. If respiratory suppression can be predicted before endoscopy, incidental complications can conceivably be prevented. In the present study, we focused on the relation between respiratory suppression from sedation and lung function.
International Journal of Gastrointestinal Cancer | 2005
Kazuhiro Sakamoto; Makoto Takahashi; Yukihiro Yaginuma; Yasunori Ishido; Takashi Matsuoka; Shuichi Sakamoto; Yuichi Tomiki; Toshiki Kamano
Positron emission tomography (PET) is a noninvasive functional imaging modality that can disclose the presence of a malignant disease. It has recently been reported that PET may be useful to detect primary colorectal cancer (CRC). We present the case of a 47-yr-old man with early colon cancer detected by 18F-fluorodeoxyglucose (FDG) PET. The patient consulted us because of a positive fecal occult blood test and focal FDG uptake in the pelvic cavity detected at a physical check-up. After the usual work up, he was diagnosed as having a sigmoid polyp, 16 mm in diameter. Subsequently, colonoscopic polypectomy was carried out. The surgical specimen was histologically diagnosed as a well-differentiated adenocarcinoma, invading the submucosal layer with lymphatic invasion. Therefore, the involved portion of the sigmoid colon was laparoscopically resected. The FDG PET carried out 1 yr after the operation, showed no abnormal FDG uptake. PET can noninvasively detect an early colon cancer as small as in our patient, as well as other cancers in the whole body. Therefore, we consider it suitable as a screening examination.
Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 2007
Yutaka Kojima; Toshiki Kamano; Kazuhiro Sakamoto; Mitsuhiro Matsuda; Hironobu Sengoku; Naohito Takita; Yukihiro Yaginuma; Eishin Nonaka; Daisuke Kitamura; Seigo Ono
Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 2012
Rina Takahashi; Kiichi Nagayasu; Syun Ishiyma; Kiichi Sugimoto; Hirohiko Kamiyama; Yukihiro Yaginuma; Yutaka Kojima; Hironobu Sengoku; Yuichi Tomiki; Kazuhiro Sakamoto
Pediatric Dermatology | 2011
Hirohiko Kamiyama; Kiichi Nagayasu; Koichiro Niwa; Seigo Ono; Shun Ishiyama; Kiichi Sugimoto; Yukihiro Yaginuma; Makoto Takahashi; Yutaka Kojima; Michitoshi Goto; Hironobu Sengoku; Yuichi Tomiki; Bunsei Nobukawa; Takashi Yao; Sumio Watanabe; Kazuhiro Sakamoto
Clinical Journal of Gastroenterology | 2011
Yuichi Tomiki; Seigo Ono; Shun Ishiyama; Kiichi Sugimoto; Yukihiro Yaginuma; Makoto Takahashi; Yutaka Kojima; Michitoshi Goto; Kazuhiro Sakamoto; Shu Hirai