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Featured researches published by Yukihito Kokuba.


Surgery Today | 2007

Gastrointestinal Stromal Tumor of the Rectum Resected by Laparoscopic Surgery: Report of a Case

Takatoshi Nakamura; Atsushi Ihara; Hiroyuki Mitomi; Yukihito Kokuba; Takeo Sato; Heita Ozawa; Kazuhiko Hatade; Wataru Onozato; Masahiko Watanabe

A 53-year-old man visited our hospital with the chief complaint of pain on urination. On digital rectal examination, a rigid immobile tumor mass with a smooth surface was palpated on the anterior wall on the right side of the rectum near the anal canal. Computed tomography (CT) and magnetic resonance imaging (MRI) of the pelvis revealed a heterogeneous tumor mass measuring 6.5 cm in diameter, which occupied the cavity of the lesser pelvis. This rectal tumor was diagnosed to be a gastrointestinal stromal tumor (GIST) based on the results of a transrectal needle biopsy. A laparoscopic abdominoperineal resection of the rectum was performed to remove the mass. The intraoperative findings showed an ambiguous boundary between the tumor and the rectum but clear boundaries between the tumor and the peripheral organs, and the use of a laparoscope allowed for a good separation by providing a good visual field. The bleeding volume was approximately 80 ml and the operative time was 320 min. The macroscopic findings of excised specimens of the mass showed the tumor, measuring 6.5 × 5.5 × 5.0 cm, to be growing extrinsically from the anterior wall on the right side of the rectum. A histological examination of the excised specimens revealed at most 5 mitoses per 50 high-power fields (×400). The tumor mass was diagnosed to be a GIST of low-grade malignancy based on these findings. The postoperative course was favorable, and there were no postoperative complications. The patient was discharged on the 8th hospital day. Laparoscopic surgery is a minimally invasive surgical procedure for rectal GIST, which is excellent in terms of esthetics. Laparoscopic surgery is therefore considered to be useful for a resection of the rectum, because the magnifying effect allows surgical maneuvers with a favorable visual field within the pelvis.


Surgical Endoscopy and Other Interventional Techniques | 2006

New technique of laparoscopic colectomy with the LAP DISC and a 5-mm flexible scope

Takatoshi Nakamura; Yukihito Kokuba; H. Mitomi; Takeo Sato; Heita Ozawa; A. Ihara; Masahiko Watanabe

PurposeWe devised a new method for the safe introduction of the first trocar and induction of pneumoperitoneum for laparoscopic excision of the large intestine.MethodsWith this method, a small laparotomy is first conducted according to the size of the exposed affected intestinal tract or tumor size, prior to the application of a LAP DISC (LD) to the wound and introduction of a 12-mm trocar for the establishment of pneumoperitoneum. The method is advantageous in that organ injury and vessel injury are avoided when the small laparotomy is conducted first, and prompt transition to a conventional laparotomy is possible. The diaphragm of the iris bulb can be controlled in a non-stepwise manner. In addition, trocars, the stapler, and other instruments, can be inserted under the pneumoperitoneum. Furthermore, the use of a 5-mm flexible scope allows surgical maneuvers, except for application of LD, to be conducted via 5-mm trocars. In addition, the 5-mm scope can be inserted through any trocar, allowing multidirectional avoidance of dead space and intraperitoneal observation. When only 5-mm trocars are used, it is not necessary for the sites of trocar puncture to be closed by sutures, and this minimizes the risk of adhesions and port-site herniation. The method is also considered to be excellent from the point of view of esthetics.ResultsWe employed this surgical approach in 50 patients with colorectal cancer at our hospital. None of the patients developed any traumatic complications associated with the insertion of trocars, and none of the patients, even those with a past history of abdominal operation, required conversion to conventional laparotomy.ConclusionsBased on these results, this method involving a small laparotomy prior to the application of an LD and introduction of a 12-mm trocar for establishing pneumoperitoneum, with the efficient use of a 5-mm flexible camera, is considered to be safe and useful for laparoscopic excision of the large intestine.


World Journal of Surgery | 2008

Surgical Resection of Stage IV Colorectal Cancer and Prognosis

Hiroshi Katoh; Keishi Yamashita; Yukihito Kokuba; Takeo Satoh; Heita Ozawa; Kazuhiko Hatate; Atsushi Ihara; Takatoshi Nakamura; Wataru Onosato; Masahiko Watanabe


International Journal of Radiation Oncology Biology Physics | 2007

PHASE I TRIAL OF NEOADJUVANT PREOPERATIVE CHEMOTHERAPY WITH S-1 AND IRINOTECAN PLUS RADIATION IN PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER

Takeo Sato; Yukihito Kokuba; Wasaburo Koizumi; Kazushige Hayakawa; Isao Okayasu; Masahiko Watanabe


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 2000

A CASE OF UNDIFFERENTIATED CANCER WITH NEUROENDOCRINE DIFFERENTATION OF THE SMALL INTESTINE ACCOMPANIED BY MULTIPLE SMALL BOWEL METASTASES

Takatoshi Nakamura; Yoshimasa Otani; Yukihito Kokuba; Hideki Kanazawa; Shigeaki Aihara; Akira Kakita


Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 2007

A Case of Lymphangioma of the Ileum Presenting with Intussusception

Ataru Onozato; Takatoshi Nakamura; Kazuhiko Hatate; Heita Ozawa; Takeo Satou; Yukihito Kokuba; A. Ihara; Masahiko Watanabe


Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 2001

Laparoscoy-Assisted Ileal-Pouch Anal-Canal Anastomosis for Ulcerative Colitis.

Yoshimasa Otani; Takatoshi Nakamura; Hideki Kanazawa; Nariaki Aihara; Yukihito Kokuba; Atsushi Ihara; Akira Kakita


Nippon Daicho Komonbyo Gakkai Zasshi | 2007

A Case of Laparoscopis Surgery for Small Intestine Metastasis of Carcinosarcoma of the Lung Presenting with Intussusception

W. Onozato; Takatoshi Nakamura; Kazuhiko Hatate; Heita Ozawa; T. Satou; Yukihito Kokuba; A. Ihara; Masahiko Watanabe


Nippon Daicho Komonbyo Gakkai Zasshi | 2006

A Case of Lesser Omental Hernia after Laparoscopic Total Colorectomy for Ulcerative Colitis

Heita Ozawa; Kazuhiko Hatate; Takeo Sato; Wataru Onosato; Takatoshi Nakamura; Yukihito Kokuba; A. Ihara; Masahiko Watanabe


Nippon Daicho Komonbyo Gakkai Zasshi | 2005

Prognostic Significant of TNM Classification in the Regional Lymph Node Metastases of Colorectal Carcinoma: Comparison with Japanese General Rules

Takatoshi Nakamura; Hiroyuki Mitomi; Shiro Kikuchi; Takeo Satoh; Heita Ozawa; Yukihito Kokuba; A. Ihara; M.Y. Ootani; Masahiko Watanabe

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