Yukiko Masui

A case of allergic contact dermatitis caused by arbutin

Keywords: allergic contact dermatitis; arbutin; CAS no. 497-76-7; cosmetics; patch testing; skin-whitening

A Missense Mutation in the Death Domain of EDAR Abolishes the Interaction with EDARADD and Underlies Hypohidrotic Ectodermal Dysplasia

Background: Hypohidrotic ectodermal dysplasia (HED) is a rare condition characterized by hypotrichosis, hypohidrosis and hypodontia. The disease shows X-linked recessive, autosomal-dominant or autosomal-recessive inheritance trait. X-linked form of HED is caused by mutations in the EDA gene, while autosomal forms are caused by mutations in either EDAR or EDARADD genes. Methods: We analyzed the DNA from a Japanese patient with HED through direct sequencing, and also performed functional studies for the mutation. Results: We identified a homozygous missense mutation c.1073G>A (p.R358Q) in the EDAR gene of the patient, which was a nonconservative amino acid substitution within the death domain of EDAR protein. We demonstrated that the p.R358Q mutant EDAR protein lost its affinity to EDARADD, leading to reduced activation of the downstream NF-ĸB. Conclusion: Our data further suggest the crucial role of the EDAR signaling in development of hair, teeth, and sweat gland in humans.

A case of allergic contact dermatitis caused by goalkeeper gloves

Department of Dermatology, Niigata University School of Medicine, Niigata, Japan Nagata Clinic, Niigata, Japan National Institute of Technology and Evaluation, Tokyo, Japan Correspondence Dr Atsuko Aizawa, Department of Dermatology, Niigata University School of Medicine, 1 Asahimachidori, Chuouku. Niigata 951-8510, Japan. Email: a-nozawa@med.niigata-u.ac.jp

Case of allergic contact dermatitis due to 1,3-butylene glycol.

1,3‐Butylene glycol (1,3‐BG) is widely used in cosmetics, including low‐irritant skin care products and topical medicaments, as an excellent and low‐irritation humectant. We report a case of allergic contact dermatitis caused by 1,3‐BG. A 28‐year‐old woman suffered from an itchy erythematous eruption on her face. By 2 days of closed patch testing, her own cosmetics and many of the hypo‐irritant skin care products showed positive results. A second patch testing showed positive reaction to 1,3‐BG (1% and 5%). 1,3‐BG was a common component in most of the products that had elicited a positive reaction in the first patch testing. Although allergic contact dermatitis due to 1,3‐BG is not so common, we have to consider 1,3‐BG as a possible contact allergen in the patients presenting with allergic contact dermatitis due to various cosmetics.

Hypohidrotic ectodermal dysplasia caused by a missense mutation in the EDA gene

ejd.2011.1460 Auteur(s) : Atsushi Fujimoto1,2, Muhammad Farooq2, Nobuyuki Sato1, Yukiko Masui1, Hiroki Fujikawa1,2, Masaaki Ito1, Yutaka Shimomura2 yshimo@med.niigata-u.ac.jp 1 Division of Dermatology 2 Laboratory of Genetic Skin Diseases, Niigata University Graduate School, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan Hypohidrotic ectodermal dysplasia (HED) is a rare condition characterized by abnormal development of hair, teeth, and sweat glands. In most cases, HED shows an X-linked [...]