Yukitsugu Ono
Ajinomoto
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Publication
Featured researches published by Yukitsugu Ono.
Bioorganic & Medicinal Chemistry Letters | 2008
Takashi Yamamoto; Seiji Niwa; Seiji Ohno; Munetaka Tokumasu; Yoko Masuzawa; Chika Nakanishi; Akira Nakajo; Tomoyuki Onishi; Hajime Koganei; Shinichi Fujita; Tomoko Takeda; Morikazu Kito; Yukitsugu Ono; Yuki Saitou; Akira Takahara; Seinosuke Iwata; Masataka Shoji
In order to find an injectable and selective N-type calcium channel blocker, we have performed the structure-activity relationship (SAR) study on the 2-, 5-, and 6-position of 1,4-dihydropyridine-3-carboxylate derivative APJ2708 (2), which is a derivative of Cilnidipine and has L/N-type calcium channel dual inhibitory activities. As a consequence of the optimization, 6-dimethylacetal derivative 7 was found to have an effective inhibitory activity against N-type calcium channels with more than 170-fold lower activity for L-type channel compared to that of APJ2708.
Hypertension Research | 2003
Akira Takahara; Shinichi Fujita; Keiko Moki; Yukitsugu Ono; Hajime Koganei; Satoshi Iwayama; Hiroshi Yamamoto
Bioorganic & Medicinal Chemistry Letters | 2006
Takashi Yamamoto; Seiji Niwa; Seiji Ohno; Tomoyuki Onishi; Hiroyuki Matsueda; Hajime Koganei; Hisayuki Uneyama; Shinichi Fujita; Tomoko Takeda; Morikazu Kito; Yukitsugu Ono; Yuki Saitou; Akira Takahara; Seinosuke Iwata; Masataka Shoji
Bioorganic & Medicinal Chemistry | 2006
Takashi Yamamoto; Seiji Niwa; Satoshi Iwayama; Hajime Koganei; Shinichi Fujita; Tomoko Takeda; Morikazu Kito; Yukitsugu Ono; Yuki Saitou; Akira Takahara; Seinosuke Iwata; Hiroshi Yamamoto; Masataka Shoji
Archive | 1999
Naoyuki Fukuchi; Fumie Futaki; Morikazu Kito; Seiichi Sato; Takayuki Kajiura; Yukitsugu Ono; Koichi Ishii; Akiko Tanaka; Junko Shinozaki; Yasuko Jojima
Archive | 2001
Seiji Ohno; Kayo Otani; Seiji Niwa; Satoshi Iwayama; Akira Takahara; Hajime Koganei; Yukitsugu Ono; Shinichi Fujita; Tomoko Takeda; Masako Hagihara; Akiko Okajima
Archive | 2007
Takashi Yamamoto; Seiji Niwa; Kayo Otani; Seiji Ohno; Hajime Koganei; Satoshi Iwayama; Akira Takahara; Yukitsugu Ono; Tomoko Takeda; Shinichi Fujita; Keiko Moki
Archive | 2000
Seiji Ohno; Akiko Okajima; Seiji Niwa; Morikazu Kito; Akira Takahara; Yukitsugu Ono; Yuki Kajigaya; Tomoko Takeda; Hajime Koganei
Archive | 2003
Seiji Ohno; Kayo Otani; Seiji Niwa; Satoshi Iwayama; Akira Takahara; Hajime Koganei; Yukitsugu Ono; Shinichi Fujita; Tomoko Takeda; Masako Hagihara; Akiko Okajima
Archive | 2001
Seiji Ohno; Akiko Okajima; Seiji Niwa; Morikazu Kito; Akira Takahara; Yukitsugu Ono; Yuki Kajigaya; Tomoko Takeda; Hajime Koganei
