Yumi Nakamoto
Daiichi Sankyo
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Publication
Featured researches published by Yumi Nakamoto.
Bioorganic & Medicinal Chemistry | 2009
Kenji Yoshikawa; Shozo Kobayashi; Yumi Nakamoto; Noriyasu Haginoya; Satoshi Komoriya; Toshiharu Yoshino; Tsutomu Nagata; Akiyoshi Mochizuki; Kengo Watanabe; Makoto Suzuki; Hideyuki Kanno; Toshiharu Ohta
A series of cis-1,2-diaminocyclohexane derivatives were synthesized with the aim of optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5-6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clinical candidate, compound A. Herein, we describe the synthesis and structure-activity relationship (SAR), together with the physicochemical properties and pharmacokinetic (PK) profiles of some prospective compounds.
Bioorganic & Medicinal Chemistry | 2006
Satoshi Komoriya; Shozo Kobayashi; Ken Osanai; Toshiharu Yoshino; Tsutomu Nagata; Noriyasu Haginoya; Yumi Nakamoto; Akiyoshi Mochizuki; Takayasu Nagahara; Makoto Suzuki; Takashi Shimada; Kengo Watanabe; Yumiko Isobe; Taketoshi Furugoori
Bioorganic & Medicinal Chemistry Letters | 2008
Akiyoshi Mochizuki; Yumi Nakamoto; Hiroyuki Naito; Kouichi Uoto; Toshiharu Ohta
Archive | 2008
Toshiharu Ohta; Satoshi Komoriya; Toshiharu Yoshino; Kouichi Outo; Yumi Nakamoto; Hiroyuki Naito; Akiyoshi Mochizuki; Tsutomu Nagata; Hideyuki Kanno; Noriyasu Haginoya; Kenji Yoshikawa; Masatoshi Nagamochi; Syozo Kobayashi; Makoto Ono
Archive | 2003
Yumi Nakamoto; Toshiharu Yoshino; Hiroyuki Naito; Tsutomu Nagata; Kenji Yoshikawa; Makoto Suzuki
Heterocycles | 2008
Akiyoshi Mochizuki; Hiroyuki Naito; Yumi Nakamoto; Kouichi Uoto; Toshiharu Ohta
Archive | 2003
Toshiharu Ohta; Satoshi Komoriya; Toshiharu Yoshino; Kouichi Uoto; Yumi Nakamoto; Hiroyuki Naito; A. Daiichi Pharmaceutical Co. Ltd Mochizuki; Tsutomu Nagata; Hideyuki Kanno; Noriyasu Haginoya; Kenji Yoshikawa; M Daiichi Pharmaceutical Co. Ltd Nagamochi; Syozo Kobayashi; Makoto Ono
Archive | 2010
Tatsuya Nishi; Yumi Nakamoto; Yuichi Ochiai; Ryoko Kitazawa; Masashi Hasegawa; Hiroshi Susaki
Archive | 2010
Tatsuya Nishi; 達矢 西; Masashi Hasegawa; 雅司 長谷川; Yumi Nakamoto; 有美 中本; Yuichi Ochiai; 雄一 落合; Ryoko Kitazawa; 亮子 北澤; Hiroshi Susaki; 浩 洲崎
Archive | 2010
Tatsuya Nishi; Masashi Hasegawa; Yumi Nakamoto; Yuichi Ochiai; Ryoko Kitazawa; Hiroshi Susaki
