Yun-Jeong Kim

Geometric changes after tricuspid annuloplasty and predictors of residual tricuspid regurgitation: a real-time three-dimensional echocardiography study.

AIMSnWe sought to demonstrate geometric changes in the tricuspid valve (TV) apparatus after tricuspid annuloplasty (TAP) and to identify predictors of residual tricuspid regurgitation (TR) in patients with functional TR using real-time three-dimensional echocardiography (RT3DE).nnnMETHODS AND RESULTSnRT3DE and two-dimensional colour Doppler echocardiography were performed in 59 consecutive patients before and 4.7 ± 2.1 days after TAP. The tenting angles of the three leaflets were significantly increased, whereas tenting volume, annulus diameters, and septal-lateral right ventricular inlet dimension decreased after TAP. By multiple stepwise linear regression analysis, tenting volume (P < 0.001) and antero-posterior annulus diameter (P = 0.043) before TAP were major predictors of residual TR assessed using distal jet area. When TR severity was quantified by vena contracta width, tenting volume (P < 0.001) before TAP was the only independent predictor. Pre-TAP tenting volume ≥1.68 mL (sensitivity of 86%, specificity of 73%), and ≥2.30 mL (sensitivity of 100%, specificity of 84%) were the best cut-off values predicting severe residual TR quantified using distal jet area and vena contracta width, respectively. After TAP, tenting volume and pulmonary artery systolic pressure were major determinants of residual TR.nnnCONCLUSIONnTenting angles of all three leaflets increase, whereas annulus diameters decrease, after TAP. Pre-TAP tenting volume and antero-posterior annulus diameter measured using RT3DE are independent predictors of residual TR severity, and measurement of these parameters may help to identify patients at high risk for severe residual TR, for whom TV replacement should possibly be initially considered.

Three-dimensional characteristics of functional mitral regurgitation in patients with severe left ventricular dysfunction: a real-time three-dimensional colour Doppler echocardiography study

Objectives: We sought to evaluate the three-dimensional (3D) features of functional mitral regurgitation (FMR) and their geometric determinants by real-time 3D colour Doppler echocardiography. Methods: Real-time 3D colour Doppler echocardiography was performed in 52 patients with severe left ventricular dysfunction. With aliasing velocity set around 40 cm/s, proximal isovelocity surface area (PISA) radius was measured on medial, central and lateral antero-posterior planes at a mid-systole frame, and the largest (PISAmax) was determined. Geometric investigations of the left ventricle and mitral valve were performed. Results: The distal length from the anterior leaflet angulation on the central plane was significantly longer in the 29 patients (56%) with eccentric PISA than in the 23 patients with central PISA (1.73 (0.44) vs 1.47 (0.33) cm, p<0.05). The 18 patients (35%) with both-sides dominant PISA had a smaller anterior leaflet bending angle (141° (8°) vs 147° (8°), p<0.05) and a longer distal length from the angulation on the central plane (1.80 (0.36) vs 1.51 (0.41) cm, p<0.05) than the remaining 34 patients. The 14 patients (27%) with separate PISAs had smaller PISAmax (0.33 (0.13) vs 0.45 (0.16) cm, p<0.05), and tenting height (0.91 (0.20) vs 1.06 (0.24) cm, p<0.05) and tenting area (2.1 (0.6) vs 2.7 (0.8) cm2, p<0.05) on the central plane than in those with single PISA. Conclusions: 3D features of FMR are quite diverse. The shape and site of anterior leaflet bending determine the shape of the regurgitant orifice, and small mitral valve tenting generates separate small regurgitant orifices of FMR in patients with severe left ventricular dysfunction.

Discrepancy between mitral valve areas measured by two-dimensional planimetry and three-dimensional transoesophageal echocardiography in patients with mitral stenosis

Objective To compare mitral valve area (MVA) measurements obtained by 2D transthoracic planimetry and 3D transoesophageal echocardiography (TOE) in patients with mitral stenosis (MS), and to determine the causes of discrepancies between the two techniques. Design Reliability and agreement study. Setting Tertiary referral centre. Patients Eighty-seven patients with MS. Methods MVA was determined by transthoracic 2D planimetry and 3D TOE. Clinical and echocardiographic variables were evaluated. The angle (Mα) between the lines of the true mitral valve (MV) tip and the echo beam-to-MV tip was measured at early diastole from the parasternal long-axis view obtained from 2D echocardiography. Results Although MVA measurements using 2D planimetry and 3D TOE showed good agreement (intraclass correlation coefficient, 0.853; p<0.001), 2D planimetry overestimated MVA by 0.19±0.2u2005cm2 compared with 3D TOE (p<0.001). Left atrial (LA) dimension obtained from the parasternal long-axis view at end-systole (p=0.012), Mα (p<0.001), and left ventricular ejection fraction (p=0.022) were independent determinants of the MVA difference (MVA by 2D—MVA by 3D TOE; MVA2D–3D) according to multiple linear regression analysis. The LA dimensions correlated with Mα (r=0.352, p=0.001). The best cut-off values for predicting significant overestimation by 2D planimetry (MVA2D–3D>0.2u2005cm2) were LA dimension ≥49u2005mm (78% sensitivity, 72% specificity) and Mα≥9.5° (56% sensitivity, 89% specificity). Conclusions Because 2D planimetry tends to overestimate MVA, 3D TOE should be considered for accurate MVA assessment, especially in patients with a large LA and large Mα.

Right Ventricular Remodeling Determines Tricuspid Valve Geometry and the Severity of Functional Tricuspid Regurgitation: A Real-Time 3-Dimensional Echocardiography Study

Background and Objectives Right ventricle (RV) remodeling can determine tricuspid valve (TV) geometry and the severity of functional tricuspid regurgitation (TR). Subjects and Methods In 53 patients with various degrees of functional TR and in sinus rhythm, RV and TV geometries were analyzed using real-time 3-dimensional echocardiography, including tenting angles of 3 leaflets, septal-lateral and antero-posterior tricuspid annulus diameters and inlet RV dimensions, mid-RV septal-lateral dimension, and the distance between annulus and apex. A mid-systole frame when the TV tenting is smallest was selected for the analysis. RV end-diastolic and end-systolic volumes were measured. The severity of functional TR was determined by distal jet area. Results TR distal jet area was mainly determined by septal-lateral annulus diameter (p<0.001) RV inlet dimension (p=0.015), RV end-systolic volume (p=0.010), septal (p=0.019), and anterior leaflet tenting angles (p=0.045) by multiple stepwise linear regression analysis. Leaflet tenting angles were mainly determined by septal-lateral RV inlet dimension. Septal-lateral annulus diameter was determined by septal-lateral RV inlet dimension (p<0.001) and mid RV dimension (p=0.033), whereas antero-posterior annulus diameter was determined by antero-posterior RV inlet dimension (p<0.001). Conclusion Functional TR severity is determined by septal-lateral annulus and RV dilation, and tenting of septal and anterior leaflets. TV leaflet tenting is mainly determined by septal-lateral RV inlet dilation, and tricuspid annulus dilation is closely linked with inlet RV dilation.