Yun-Sik Choi

Inhibition of inducible NO synthase, cyclooxygenase‐2 and interleukin‐1β by torilin is mediated by mitogen‐activated protein kinases in microglial BV2 cells

Background and purpose:u2002 Traditionally, the stem and root bark of Ulmus davidiana var. japonica (Ulmaceae) have been known to be anti‐inflammatory in Korea. Anti‐inflammatory effects of torilin, isolated from this plant and the underlying mechanisms were examined by using lipopolysaccharide (LPS)‐stimulated microglial BV2 cells.

The association of cholesteryl ester transfer protein polymorphism with high-density lipoprotein cholesterol and coronary artery disease in Koreans

Cholesteryl ester transfer protein (CETP) is a key protein involved in high‐density lipoprotein cholesterol (HDL‐C) metabolism. It is known to affect plasma HDL‐C levels, and its genetic regulation may be involved in the development of coronary artery disease (CAD). The aim of this study was to determine the frequency of the CETP Taq1B polymorphism in Koreans, and to investigate its relationship with plasma HDL‐C levels and CAD. One‐hundred and nineteen patients with significant CAD and 106 controls were examined with respect to their genotypes, lipid profiles and other risk factors of CAD. The genotype frequencies of B1B1:B1B2:B2B2 in males and females were 35.5%:50%:14.5% and 34.7%:42.6%:22.7%, respectively, which is comparable to previous reports in other ethnic groups. The B1B1 homozygote was associated with significantly lower HDL‐C levels in females (p =u200a0.049) and non‐smoking males (p =u200a0.037). After controlling for gender, body mass index (BMI) and smoking, the TaqIB polymorphism was still significantly associated with HDL‐C levels (p =u200a0.046) and explained 5.4% of the HDL‐C variation in this study. By univariate analysis, the B1B1 homozygote was a significant predictor of CAD (p =u200a0.043), and this was confirmed by multivariate analysis with traditional risk factors, i.e. the B1B1 homozygote was an independent predictor of CAD (p =u200a0.026, odds ratiou2003=u20031.97, 95% confidence interval: 1.08–3.57). In conclusion, the B1B1 homozygote of the CETP Taq1B polymorphism is associated with low HDL‐C levels in females and non‐smoking males, and may be an independent genetic risk factor of CAD in the Korean population.

Oligonucleotide microarray analysis of apoptosis induced by 15‐methoxypinusolidic acid in microglial BV2 cells

Background and purpose:u2002 We conducted a genome wide gene expression analysis to explore the biological aspects of 15‐methoxypinusolidic acid (15‐MPA) isolated from Biota orientalis and tried to confirm the suitability of 15‐MPA as a therapeutic candidate for CNS injuries focusing on microglia.

SU‐FF‐T‐586: Evaluation of Dose Distribution According to Various CT Slice Thickness

Purpose: We investigated the variation of dose distributions in the treatment plans based on CTimage sets of different slice thicknesses. Method and Materials: An anthropomorphic phantom was scanned with a slice thickness of 1 mm. The acquired images were reconstructed at the slice thicknesses of 2 mm, 3 mm, 5 mm, and 10 mm. For each image set of slice thicknesses, the treatment plan was generated by using a commercial RTP system. Treatment sites were on the breast and H&N (Head & Neck). The dose distributions of 3‐axes (sagittal, transverse, and coronal) were exported at the iso‐center. The image set of 2 mm slice thickness was used as the reference. Dose differences were evaluated in terms of gamma‐index at various criteria. Results: Passing ratio of evaluating gamma‐index decreases with increasing slice thickness of images. The ratios of 3 mm, 5 mm, and 10 mm thicknesses were 96.3%, 95.9%, and 95.3%, respectively on coronal images of H&N and were 100%, 99.9%, and 93.8% on those of breast. On transversal images of both H&N and breast, the ratios were less than 90%. Conclusion: The slice thickness of CTimages affects dose distributions on treatment plans. There might be little dose difference in treatment plans based on CTimage sets of 2 to 5 mm slice thickness. However, such difference becomes considerable in the organ having a steep slope and/or high dose gradients.