Yuri A. Vorotnikov
Novosibirsk State University
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Publication
Featured researches published by Yuri A. Vorotnikov.
Journal of Materials Chemistry B | 2016
Anastasiya O. Solovieva; Yuri A. Vorotnikov; Kristina E. Trifonova; Olga A. Efremova; Anna A. Krasilnikova; Konstantin A. Brylev; Elena V. Vorontsova; Pavel A. Avrorov; Lidiya V. Shestopalova; Alexander F. Poveshchenko; Yuri V. Mironov; Michael A. Shestopalov
Silica nanoparticles (SNPs) doped by hexanuclear molybdenum cluster complexes [{Mo6X8}L6]n (X = Cl, Br, or I; L = various inorganic or organic ligands) have been recently suggested as materials with high potential for biomedical applications due to both their outstanding photoluminescence properties and their ability to efficiently generate singlet oxygen upon photoirradiation. However, no studies were undertaken so far to prove this concept. Therefore, here we examined the potential of photoluminescent SNPs doped by {Mo6I8}4+ for applications such as bioimaging and photodynamic therapy using the human epidermoid larynx carcinoma (Hep-2) cell line as a model. Our results demonstrated both: (i) significant luminescence from cells with internalised molybdenum cluster-doped SNPs combined with the low cytotoxicity of particles in the darkness and (ii) significant cytotoxicity of the particles upon photoirradiation. Thus, this research provides strong experimental evidence for high potential of molybdenum-cluster-doped materials in biomedical applications such as optical bioimaging, biolabeling and photodynamic therapy.
Journal of Inorganic Biochemistry | 2017
Anastasia M. Cheplakova; Anastasiya O. Solovieva; Tatiana N. Pozmogova; Yuri A. Vorotnikov; Konstantin A. Brylev; Natalya A. Vorotnikova; Elena V. Vorontsova; Yuri V. Mironov; Alexander F. Poveshchenko; Konstantin A. Kovalenko; Michael A. Shestopalov
Inclusion compounds of photoluminescent hexamolybdenum cluster complexes in the chromium terephthalate metal-organic framework, MIL-101 (MIL, Matérial Institut Lavoisier) were successfully synthesized in two different ways and characterized by means of powder X-Ray diffraction, chemical analysis and nitrogen sorption. Some important functional properties of hexamolybdenum cluster complexes for biological and medical applications, in particular singlet oxygen generation ability, luminescence properties, cellular uptake behavior and cytotoxicity were studied. It was revealed that the inclusion compounds possessed significant singlet oxygen generation activity. The materials obtained showed a low cytotoxicity, thus allowing them to be used in living cells. Confocal microscopy of human larynx carcinoma (Hep-2) cells incubated with the inclusion compounds showed that MIL-101 performed as a nanocarrier adhering to the external cell membrane surface and releasing the cluster complexes which that penetrated into the cells. Moreover, photoinduced generation of reactive oxygen species (ROS) in Hep-2 cells incubated with inclusion compounds was demonstrated. The cluster supported on MIL-101 was shown to possess in vivo phototoxicity.
Journal of Materials Chemistry C | 2016
Olga A. Efremova; Konstantin A. Brylev; Yuri A. Vorotnikov; Lucie Vejsadová; Michael A. Shestopalov; Gwendolen F. Chimonides; Petr Mikes; Paul D. Topham; Sung-Jin Kim; Noboru Kitamura; Andrew J. Sutherland
Materials that combine photoluminescence, optical transparency and facile processability are of high importance in many applications. This article reports on the development of photoluminescent poly(methyl methacrylate) materials based on novel highly emissive anionic molybdenum cluster complex [{Mo6I8}(OTs)6]2- (where OTs- is the p-toluenesulfonate ion). The materials were obtained by both solution and bulk copolymerisation of methyl methacrylate and (dMDAEMA)2[{Mo6I8}(OTs)6], where dMDAEMA+ is the polymerisable cation [2-(methacryloyloxy)ethyl]dimethyl-dodecylammonium. Evaluation of the resultant hybrid materials showed that one could combine the excellent photoluminescent properties of the cluster complex with the transparency and processability of PMMA.
Dalton Transactions | 2016
Olga A. Efremova; Yuri A. Vorotnikov; Konstantin A. Brylev; Natalya A. Vorotnikova; Igor N. Novozhilov; Natalia V. Kuratieva; Mariya V. Edeleva; David M. Benoit; Noboru Kitamura; Yuri V. Mironov; Michael A. Shestopalov; Andrew J. Sutherland
This article describes the synthesis, structures and systematic study of the spectroscopic and redox properties of a series of octahedral molybdenum metal cluster complexes with aromatic sulfonate ligands (nBu4N)2[{Mo6X8}(OTs)6] and (nBu4N)2[{Mo6X8}(PhSO3)6] (where X- is Cl-, Br- or I-; OTs- is p-toluenesulfonate and PhSO3- is benzenesulfonate). All the complexes demonstrated photoluminescence in the red region and an ability to generate singlet oxygen. Notably, the highest quantum yields (>0.6) and narrowest emission bands were found for complexes with a {Mo6I8}4+ cluster core. Moreover, cyclic voltammetric studies revealed that (nBu4N)2[{Mo6X8}(OTs)6] and (nBu4N)2[{Mo6X8}(PhSO3)6] confer enhanced stability towards electrochemical oxidation relative to corresponding starting complexes (nBu4N)2[{Mo6X8}X6].
RSC Advances | 2016
Yuri A. Vorotnikov; Olga A. Efremova; Natalya A. Vorotnikova; Konstantin A. Brylev; Mariya V. Edeleva; Alphiya R. Tsygankova; A. I. Smolentsev; Noboru Kitamura; Yuri V. Mironov; Michael A. Shestopalov
Photoluminescent silica-based materials are used in applications in photonics, sensing, and biological and medical sciences. Specifically, hybrid particles based on silica doped by photoluminescent octahedral molybdenum metal cluster complexes are inexpensive and readily available via the Stober process and thus are promising materials for diverse applications. We evaluated design of photoluminescent materials based on silica and {Mo6X8}4+ clusters (where X = Cl, Br, I), including how synthesis conditions (chemical composition of metal cluster precursors (Bu4N)2[{Mo6X8}(NO3)6], loading of the precursor and presence of a surfactant) influence key parameters of the final materials, such as phase composition, size and morphology of the particles and photophysical characteristics. Our study revealed that hydrolysis of the molybdenum cluster precursors during the Stober process strongly affects both morphology and photophysical parameters of the materials, especially at high loadings. At relatively low loadings of the precursors, materials doped by {Mo6I8}4+ clusters demonstrated the most promising set of properties—the highest photoluminescence quantum yields and efficient singlet oxygen generation—while particle size and morphology remained the same as for undoped SiO2 materials.
New Journal of Chemistry | 2017
Ekaterina V. Svezhentseva; Anastasiya O. Solovieva; Yuri A. Vorotnikov; Olga G. Kurskaya; Konstantin A. Brylev; Alphiya R. Tsygankova; Mariya V. Edeleva; Svetlana N. Gyrylova; Noboru Kitamura; Olga A. Efremova; Michael A. Shestopalov; Yuri V. Mironov; Shestopalov Am
The development of water-soluble forms of octahedral molybdenum clusters {Mo6X8}4+ (X = Cl, Br, I) is strongly motivated by the tremendous potential that these complexes have for biological applications, namely as agents for bioimaging and photodynamic therapy. In this work, we report the first water-soluble hybrid materials, which represent sodium polystyrene sulfonate doped by molybdenum clusters, and the evaluation of their photophysical and biological properties (dark and photoinduced cytotoxicity and cellular uptake) with the use of cervical cancer (HeLa) and human epidermoid larynx carcinoma (Hep-2) cell-lines as models.
Inorganic Chemistry | 2018
Natalya A. Vorotnikova; Yuri A. Vorotnikov; Igor N. Novozhilov; Mikhail M. Syrokvashin; V. A. Nadolinny; Natalia V. Kuratieva; David M. Benoit; Yuri V. Mironov; Richard I. Walton; Guy J. Clarkson; Noboru Kitamura; Andrew J. Sutherland; Michael A. Shestopalov; Olga A. Efremova
Photoactive transition metal compounds that are prone to reversible redox reactions are important for myriad applications, including catalysis, optoelectronics, and sensing. This article describes chemical and electrochemical methods to prepare cluster complex (Bu4N)[{Mo6I8}Cl6], a rare example of a 23 e- cluster complex within the family of octahedral clusters of Mo, W, and Re. The low temperature and room temperature crystal structures; electronic structure; and the magnetic, optical, and electrochemical properties of this complex are described.
Chemistry: A European Journal | 2018
Ekaterina V. Svezhentseva; Yuri A. Vorotnikov; Anastasiya O. Solovieva; Tatiana N. Pozmogova; Ilia V. Eltsov; Anton A. Ivanov; Darya V. Evtushok; Svetlana M. Miroshnichenko; Vadim V. Yanshole; Charlotte J. Eling; Ali M. Adawi; Jean-Sebastien Bouillard; Natalia V. Kuratieva; Maria S. Fufaeva; Lidiya V. Shestopalova; Yuri V. Mironov; Olga A. Efremova; Michael A. Shestopalov
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6 I8 }(DMSO)6 ](NO3 )4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.
Journal of Molecular Structure | 2017
Yuri A. Vorotnikov; Olga A. Efremova; Igor N. Novozhilov; Vadim V. Yanshole; Natalia V. Kuratieva; Konstantin A. Brylev; Noboru Kitamura; Yuri V. Mironov; Michael A. Shestopalov
Dalton Transactions | 2017
Darya V. Evtushok; Anatoly R. Melnikov; Natalya A. Vorotnikova; Yuri A. Vorotnikov; Alexey A. Ryadun; Natalia V. Kuratieva; Konstantin V. Kozyr; Natalia R. Obedinskaya; Evgeniy I. Kretov; Igor N. Novozhilov; Yuri V. Mironov; Dmitri V. Stass; Olga A. Efremova; Michael A. Shestopalov