Yuri Hibino

Health impact of disaster‐related stress on pregnant women living in the affected area of the Noto Peninsula earthquake in Japan

Aims:  The present study assessed the health impact of stress on women who were pregnant during, or immediately after, a major earthquake and were living in the disaster area. Inherent resistance against the stress induced by the earthquake was also assessed.

Assessment of workplace bullying and harassment: Reliability and validity of a Japanese version of the negative acts questionnaire

Assessment of Workplace Bullying and Harassment: Reliability and Validity of a Japanese Version of the Negative Acts Questionnaire: Jiro Takaki, et al. Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Interactive Effects of Job Stress and Body Mass Index on Over-eating

Interactive Effects of Job Stress and Body Mass Index on Over‐eating: Jiro Takaki, et al. Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Exploring Factors Associated With the Incidence of Sexual Harassment of Hospital Nurses by Patients

PURPOSE To identify factors affecting nurse-perceived sexual harassment and specific types of patient sexual behavior experienced by Japanese nurses. DESIGN Cross-sectional questionnaire study of Japanese hospital nurses. METHODS Self-administered questionnaires (N=600) were distributed to Japanese hospital nurses, and 464 were returned (response rate of 77.3%). Two instruments were used: one was for determining sexual harassment by patients, and the other was for determining specific types of patient behavior that had sexual connotations. FINDINGS Registered nurses were at a much higher risk of sexual harassment than were nurse assistants. In addition, registered nurses had a much more positive attitude toward gender equality compared with assistant nurses. CONCLUSIONS A positive attitude toward gender equality mediated by a relatively high education level might be associated with increasing reports of sexual harassment. An increasing incidence of sexual harassment claims among nurses should prompt hospital organizations to take proper action against it. Education on gender equality was thus considered a long-term solution for reducing the sexual harassment of Japanese hospital nurses. CLINICAL RELEVANCE Establishing a safer working environment could enable nurses to provide better care for patients and thereby promote the development of good relationships between nurses and patients.

Association between altered systemic inflammatory interleukin‐1β and natural killer cell activity and subsequently agitation in patients with alzheimer disease

Alzheimers disease (AD) is a neurodegenerative disorder that is the most common cause of dementia in the elderly and is frequently accompanied by emotional disorder, including agitation. Although evidence of neuroendocrine immune and inflammatory functions during emotional changes has been accumulated, the pathogenic mechanisms in the development of agitation accompanied by AD remain to be elucidated.

The Differences in the Involvements of Loci of Promoter Region and Ile50Val in Interleukin-4 Receptor α Chain Gene between Atopic Dermatitis and Japanese Cedar Pollinosis

BACKGROUND Atopic dermatitis (AD) and Japanese cedar pollinosis (JCP) are common chronically allergic diseases associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for IL-4 receptor α chain (IL4RA) may contribute to susceptibility of AD and JCP, although the differences in the involvements of loci of IL4RA gene between AD and JCP are unclear. In this study, we investigated the role of polymorphisms in IL-4RA gene in conferring susceptibility to the development of AD and/or JCP using a family analysis and an association analysis in a Japanese population. METHODS Five polymorphisms in the IL-4RA gene, C-3223T, T-1914C, T-890C, Ile50Val and Glu375Ala, have been genotyped using PCR-based methods in 75 trios families, including 15 AD families, 30 JCP families, and 30 families with combination of AD and JCP in the family analysis. Forty-five AD, 60 JCP and 125 control children constituted the association study. RESULTS The transmission disequilibrium test showed that the allele of Ile50 was significantly transmitted to children with JCP alone (p < 0.05). Haplotype analysis showed that the -3223T/Ile50 haplotype was preferentially transmitted to both AD (p < 0.01) and JCP children (p < 0.01), while that the C-3223/Ile50 haplotype was preferentially transmitted to only JCP children (p < 0.01). The association study showed that -3223T and haplotype of -3223T/Ile50 were associated with AD children, but not with JCP. Ile50 was associated with both AD and JCP. CONCLUSIONS Our data suggest that -3223T and the -3223T/Ile50 haplotype were risk factors for AD. Ile50 allele seems to be involved in both JCP and AD. Interactions of the IL-4RA loci may play a role both conferring susceptibility and modulating severity of AD.

Becoming a Surrogate Online : "Message Board" Surrogacy in Thailand

The development of assisted reproductive technologies (ARTs) over the past several decades has enabled infertile couples to fulfil their desire to have their children. In particular, in vitro fertilisation (IVF) has made it possible to “separate the procreation of an embryo from its gestation”, thereby giving rise to various novel possibilities for infertile couples to have children. These include “the possibility of finding substitutes not just for parental genetic material but for the womb” (Strathern 2003). The practice of nourishing another’s foetus in the womb is known as surrogacy. Surrogacy has been the most contentious use of ARTs. Although surrogacy is totally prohibited in some European countries such as Germany, France, and Austria, it is permitted in a non-commercial form in other countries such as the UK. The US has long been the sole country in which commercial surrogacy has been practised openly, with some states permitting the operation of for-profit agencies that arrange surrogacy contracts. However, this situation has been rapidly changing during the past decade. With the dissemination of ARTs throughout the world, the practice of commercial surrogacy has been developing in other countries. In particular, India has been emerging as a hub of transnational surrogacy and has attracted many individuals from around the world. Whereas commercial surrogacy has not yet evolved into a huge industry as it has in India, it is nonetheless being practised in Thailand, where about 30 IVF clinics are currently operating and approximately 3,000–4,000 IVF cycles are performed annually. According to national records, 2,623 IVF F I N D I N G S

Increased systemic inflammatory interleukin‐1ß and interleukin‐6 during agitation as predictors of Alzheimer's disease

Identification of biomarkers for Alzheimers disease (AD) is important for its early diagnosis and prevention and a key in advancing our understanding of its pathophysiology. The aim of this study was to determine whether systemic inflammatory interleukin‐1ß (IL‐1ß) and interleukin‐6 (IL‐6) as well as hypertension (HT), diabetes mellitus (DM), and body mass index (BMI) are predictors of AD.

Preparation and Characterization of a Polyclonal Antibody against Brominated Protein

(Di)bromotyrosine is formed by the specific reaction of eosinophil peroxidase and can be used as an eosinophil activation marker. In the present study, an antibody for (di)bromotyrosine in proteins was prepared to investigate the pathogenesis of eosinophil-related diseases such as allergic responses. A rabbit polyclonal antibody was raised against brominated keyhole limpet hemocyanin. The specificity of the antiserum was investigated with an enzyme-linked immunosorbent assay (ELISA). The antiserum recognized brominated bovine serum albumin (BSA) and dibromotyrosine-conjugated BSA. The antiserum also reacted with chlorinated BSA and di-iodotyrosine-conjugated BSA. Moreover, the specificity of the antiserum was investigated using competitive ELISA. Dibromotyrosine and di-iodotyrosine inhibited the recognition of brominated BSA by the antiserum. However, the recognition of brominated BSA by the antiserum was not inhibited by bromotyrosine, chlorotyrosine, iodotyrosine, nitrotyrosine, aminotyrosine, phosphotyrosine, or tyrosine. These results suggested that the epitope of the antiserum is dihalogenated tyrosine. Immunohistochemically, the antiserum stained brominated rat eosinophils but not chlorinated or nitrated eosinophils. In conclusion, an antiserum for dihalogenated protein was prepared. It is expected that the antiserum will be useful for the analysis of the pathogenesis of allergic diseases such as asthma and atopic dermatitis.

Association between the incidence of premature rupture of membranes in pregnant women and seismic intensity of the Noto Peninsula earthquake

ObjectivesThe Noto Peninsula earthquake struck the coast of the Noto Peninsula, Japan on March 25, 2007, resulting in the death of one woman and injury to 356 people. A total of 684 houses were totally destroyed by this earthquake, and more than 2,500 people were forced to live at shelters. In this study, we have evaluated the association between the incidence of peripartum abnormalities and seismic intensity of the Noto Peninsula earthquake.MethodsDemographic data, births, seismic intensity of the earthquake and the incidence of peripartum abnormalities between June 25, 2007 and January 31, 2008 were surveyed. The dataset included 126 pregnant women who lived in the disaster area. The seismic intensity of the earthquake was expressed on the scale (0–7, with 7 being the strongest measure) used by the Japan Meteorological Agency. The subjects of the analysis included 19.7% of the pregnant women affected by the disaster.ResultsOf the pregnant women included in this study, 7.9% had a premature rupture of membranes (PROM), with the percentage being significantly higher in the group that experienced a seismic intensity of 6 than in that experienced a seismic intensity of 5.ConclusionsOur epidemiologic study shows that the PROM among our study cohort was associated with seismic intensity, suggesting that the physical outcome was due to aftershocks of the earthquake at a seismic intensity ≥6. This outcome may result from the psychological stress caused by the earthquakes.