Yuriy S. Marfin
Ivanovo State University of Chemistry and Technology
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Featured researches published by Yuriy S. Marfin.
Current Medicinal Chemistry | 2017
Yuriy S. Marfin; Alexey V. Solomonov; Alexander S. Timin; Evgeniy V. Rumyantsev
BACKGROUND The group of fluorophores on boron dipyrrin platform (4,4- difluoro-4-bora3a,4a-diaza-s-indacene, also known as BODIPY) has attracted much attention in the field of molecular sensorics, including sensing of biomolecules and bioprocesses. Structural diversity of existing BODIPY with ample opportunities of directed modification of compounds makes this class of fluorophores attractive for medical and biological purposes. The recent progress in the design and functionalization of BODIPY allows using them for modification of drug micro- and nanocarriers in order to improve their therapeutic effect in cancer treatment. At the same time, integration of BODIPY into drug carriers provides the possibility of in vitro and in vivo real time imaging of used drug carriers. The high fluorescent intensity and low toxicity of BODIPY granted for conjugation with different biomolecules. RESULTS The present review focuses on the recent advances for application of individual BODIPY in medical diagnostics, antimicrobial activity, as well as establishing the role of BODIPY in labeling of biomolecules (e.g. proteins, hormones and DNA). Also the review highlights the potential of BODIPY in functionalization of drug micro- and nanocarriers in order to achieve better therapeutic efficiency compared with non-modified materials. The advantages derived from the use of BODIPY for preparation and modification of drug carriers are critically evaluated and potential for future challenges, especially concerning the design of innovative multi-functional BODIPY-based nanocarriers, is discussed in detail using representative examples from literature. CONCLUSION Our objective was to show that BODIPY are powerful tools for bioimaging, labeling of biomolecules and construction of new multifunctional drug carriers.
Journal of Fluorescence | 2014
Yuriy S. Marfin; Dmitry A. Merkushev; G. A. Levshanov; Evgeniy V. Rumyantsev
Fluorescent characteristics of two BODIPY dyes in solutions were investigated under the viscosity variations. Investigated dyes differ in the nature of 8-substituent of ligand molecule. Viscosity variation was achieved by changing of solvent composition in the binary system ethanol - ethylene glycol and solvent temperature. 8-Phenyl substituted BODIPY is found to exhibit properties of molecular rotor, i.e. its fluorescent characteristics are highly dependent on the viscosity or rigidity of the microenvironment. Increased temperature leads to a linear decrease of fluorescence parameters unlike the solvent composition variation where fluorescence change is nonlinear. The highest specific change in the fluorescence was observed in pure ethanol. Change in the nonradiative decay rate constant values with the increasing of viscosity indicates that the analyzed phenyl substituted complex is a true molecular rotor. Investigated 8-phenylBODIPY could be recommended as promising viscosity sensor in different organic media.
Plasma Chemistry and Plasma Processing | 2016
Anna Khlyustova; Natalija Khomyakova; Nikolaj Sirotkin; Yuriy S. Marfin
Formation of hydroxyl radicals in aqueous solutions by atmospheric pressure DC glow discharge was investigated. The ferrocyanide was used as an OH scavenger at different pH. Experimental results indicated that pH effect on hydroxyl radical formation rate could be explained by particularities of [Fe(CN)6]4− and reactive species interaction in different media.
Journal of Fluorescence | 2016
Yuriy S. Marfin; Olga S. Vodyanova; Dmitry A. Merkushev; Sergey D. Usoltsev; Vladislav O. Kurzin; Evgeniy V. Rumyantsev
Four boron-dipyrrine (BODIPY) based dyes with π-extended substituents in 8-position of dipyrrin ligand have been synthesized and characterized. Photophysical properties of the obtained compounds have been investigated in different individual solvents. Deposits of solvent polarity and viscosity were evaluated. BODIPY with 8-biphenyl substituent was found to be the fluorescent molecular rotor in contrast to more extended substituents. The complex nature of solvent-solute interactions leads to the poor applicability of standard multiparameter approaches to BODIPY solvatochromic properties. Fluorescence intensity was found to increase in case of solvent polarity growth, it is not typical for BODIPY. Taking that into account the BODIPY with π-extended substituents could be used for fluorescence viscosity measurements, and as the fluorescent media polarity indicators in analytical chemistry and biochemistry.
Materials Technology | 2017
Alexander V. Bobrov; Yuriy S. Marfin; Vladimir V. Kuznetsov; Evgeniy V. Rumyantsev
Silicon dioxide thin films with organic fluorescent dyes with different amount of matrix layers were prepared by sol–gel spin coating and dripping technique, synthetic and subsequent treatment parameters were proposed for obtaining materials with high homogeneity and dye stability. The structural, morphological and optical properties of obtained materials have been studied by X-ray diffraction, atomic force microscopy and ultraviolet–visible spectroscopy. Immobilisation of the dye increases the degree of film amorphousness. Immobilisation greatly affects the spectral properties of coumarin 6 and BODIPY due to the dye protonation by acid catalyst, this effect is reversible in case of coumarin 6. Rhodamine 6G spectral characteristics are not influenced by immobilisation. In the hybrid materials monomeric form of the dyes retained at higher concentration compared with solutions. Dye immobilisation was found to increase dyes photostability.
Transition Metal Chemistry | 2014
Evgeniy V. Rumyantsev; Yuriy S. Marfin
Complexes of Pd(II), Cu(II), Ni(II), and Zn(II) with alkylated dipyrrins (Hdpm) were synthesized and characterized by physicochemical and spectroscopic methods. Protolytic dissociation kinetics of these complexes in benzene in the presence of acetic and trichloroacetic acid was studied. A protonated dipyrrin is the reaction product of protolytic dissociation of the complexes in acid solutions. The observed and true dissociation rate constants, as well as activation reaction parameters, were calculated. Kinetic models of the processes are proposed, and the patterns of influence of the ligand nature on dissociation kinetics were determined. The Pd(II) complexes proved to be much more stable than other those of the other metals, according to the results of the kinetic studies. The lability of the complexes strongly depends on the length and position of the alkyl substituent of the ligand. The dissociation of the Ni(II) complex gives a heteroligand complex at low concentrations of acid, but the complex undergoes full protolytic dissociation at higher concentrations of acid. The dissociation of the complex of Cu(II) is an equilibrium process, involving formation of the protonated form of the ligand.
Inorganica Chimica Acta | 2013
Evgeniy V. Rumyantsev; Sergey N. Alyoshin; Yuriy S. Marfin
Journal of Fluorescence | 2015
Yuriy S. Marfin; Dmitry A. Merkushev; Sergey D. Usoltsev; Maria V. Shipalova; Evgeniy V. Rumyantsev
Synthetic Metals | 2016
Ilya Tarasyuk; Ilya Kuzmin; Yuriy S. Marfin; Artur Vashurin; Alena Voronina; Evgeniy V. Rumyantsev
Journal of Photochemistry and Photobiology A-chemistry | 2018
Olga S. Vodyanova; B. A. Kochergin; Sergey D. Usoltsev; Yuriy S. Marfin; Evgeniy V. Rumyantsev; Elena L. Aleksakhina; Irina K. Tomilova