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Dive into the research topics where Yuriy Zinchenko is active.

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Featured researches published by Yuriy Zinchenko.


Operations Research Letters | 2008

Polytopes and arrangements: Diameter and curvature

Antoine Deza; Tamás Terlaky; Yuriy Zinchenko

We introduce a continuous analogue of the Hirsch conjecture and a discrete analogue of the result of Dedieu, Malajovich and Shub. We prove a continuous analogue of the result of Holt and Klee, namely, we construct a family of polytopes which attain the conjectured order of the largest total curvature.


Archive | 2009

Central Path Curvature and Iteration-Complexity for Redundant Klee—Minty Cubes

Antoine Deza; Tamás Terlaky; Yuriy Zinchenko

We consider a family of linear optimization problems over the n-dimensional Klee—Minty cube and show that the central path may visit all of its vertices in the same order as simplex methods do. This is achieved by carefully adding an exponential number of redundant constraints that forces the central path to take at least 2 n –2 sharp turns. This fact suggests that any feasible path-following interior-point method will take at least O(2 n ) iterations to solve this problem, whereas in practice typically only a few iterations (e.g., 50) suffices to obtain a high-quality solution. Thus, the construction potentially exhibits the worst-case iteration-complexity known to date which almost matches the theoretical iteration-complexity bound for this type of methods. In addition, this construction gives a counterexample to a conjecture that the total central path curvature is O(n).


Physics in Medicine and Biology | 2013

A moment-based approach for DVH-guided radiotherapy treatment plan optimization

M Zarepisheh; Mohammad Shakourifar; G Trigila; P S Ghomi; S Couzens; A Abebe; L Noreña; W Shang; S Jiang; Yuriy Zinchenko

The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.


Discrete and Computational Geometry | 2009

A Continuous d -Step Conjecture for Polytopes

Antoine Deza; Tamás Terlaky; Yuriy Zinchenko

The curvature of a polytope, defined as the largest possible total curvature of the associated central path, can be regarded as a continuous analogue of its diameter. We prove an analogue of the result of Klee and Walkup. Namely, we show that if the order of the curvature is less than the dimension d for all polytopes defined by 2d inequalities and for all d, then the order of the curvature is less that the number of inequalities for all polytopes.


Optimization Letters | 2008

On hyperbolicity cones associated with elementary symmetric polynomials

Yuriy Zinchenko

Elementary symmetric polynomials can be thought of as derivative polynomials of


Electronic Notes in Discrete Mathematics | 2008

Diameter and Curvature: Intriguing Analogies

Antoine Deza; Tamás Terlaky; Feng Xie; Yuriy Zinchenko


international conference on information systems | 2016

Optimal Transmission Network Topology for Resilient Power Supply

Yuriy Zinchenko; Haotian Song; William D. Rosehart

E_n(x)=\prod_{i=1,\ldots,n} x_i


Physics in Medicine and Biology | 2016

Modulated photon radiotherapy (XMRT): an algorithm for the simultaneous optimization of photon beamlet energy and intensity in external beam radiotherapy (EBRT) planning

P McGeachy; Jose Eduardo Villarreal-Barajas; Yuriy Zinchenko; Rao Khan


Medical Physics | 2016

SU-F-T-333: Deliverability Considerations in Modulated Photon Radiotherapy (XMRT)

P McGeachy; S Weppler; J Villarreal-Barajas; Yuriy Zinchenko; Rao Khan

. Their associated hyperbolicity cones give a natural sequence of relaxations for


Archive | 2015

A preliminary study on the effect of modulated photon radiotherapy (XMRT) optimization for prostate cancer treatment planning

P McGeachy; J Villarreal-Barajas; Yuriy Zinchenko; Pooyan Shirvani; Rao Khan

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Rao Khan

Washington University in St. Louis

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Harald Keller

Princess Margaret Cancer Centre

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Michael B. Sharpe

Princess Margaret Cancer Centre

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Rao Khan

Washington University in St. Louis

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