Yusuf Ergün

Lidocaine for pain control during intrauterine device insertion

The aim of this study was to compare the effects of topical lidocaine spray, cream and injection on pain perception during intrauterine device (IUD) insertion.

A rare case of leiomyosarcoma localized in the Bartholin's gland area and review of the literature

Sarcomas of the vulva in the Bartholins gland area are extremely rare in adults and only a few cases have been reported in the literature. A 65‐year‐old female patient without any previous complaint presented to our hospital complaining of a genital lump with progressive enlargement over the last six months. Pelvic examination revealed a 6 × 5 cm solid mass lesion with irregular margins localized in the left Bartholins gland. Preoperative pathology results indicated a benign lesion, which was subsequently totally excised. Histopathological examination of the lesion revealed leiomyosarcoma. When a lesion is localized in the Bartholins gland area, preoperative biopsy may suggest benign cytology, which can lead to a delay in diagnosis and curative treatment. Total local excision is the first choice for vulvar‐complicated masses in the Bartholins gland area. The present case is the ninth well‐documented case reported in the literature.

Comparison of Amniotic Fluid Cytokine Levels in Postterm and Term Pregnancy: a Prospective Study

BACKGROUND To evaluate amniotic fluid pro- and anti-inflammatory cytokine levels in women with postterm and term pregnancies in labor and not in labor. METHODS The study involved three groups: postterm (Group 1, n = 29), term in labor (Group 2, n = 28), and control (Group 3, n = 30). All groups were compared with respect to age, gravidity, parity, obstetric history, gestation week, cervical dilatation and effacement, maternal serum C-reactive protein and white cell count, amniotic interleukin 4, 6, and 10 levels, birthweight, and cord blood pH. RESULTS The amniotic fluid interleukin 10 level was 24.4 ± 8.8 pg/mL in the postterm group, 13.5 ± 5.1 pg/mL in the term in labor group, and 19.8 ± 5.4 pg/mL in the control group (p < 0.001). The amniotic fluid interleukin 4 level was 86.5 ± 57.7 pg/mL in the postterm group, 38.2 ± 29.2 pg/mL in the term in labor group, and 81.9 ± 68.4 pg/mL in the control group (p = 0.002). The amniotic fluid interleukin 6 level was 329 ± 135.1 pg/mL in the postterm group, 252.8 ± 138.7 pg/mL in the term in labor group, and 227.9 ± 114.4 pg/mL in the control group (p = 0.02). There was a positive correlation between gestational age and IL-10 levels (p < 0.05). CONCLUSIONS Amniotic fluid IL-10 and IL-4 cytokine levels were increased in postterm pregnancy and they decreased with active labor.

Should we change our mind about second trimester biochemical aneuploidy screening markers of patients with polycystic ovary syndrome

test, it is still used as some patients only present for the first time in the second trimester. Therefore, the quadruple test has started to be used for Down syndrome screening in the second trimester of pregnancy. In addition to triple test parameters, the quadruple test includes inhibinA. However, Segal et al. found that serum inhibin-A concentration in women with PCOS was lower than normalovulatory women [1, 2]. In addition, Karsli et al. investigated biochemical parameters in the first trimester aneuploidy screening test in the pregnant women with and without PCOS. The biochemical components PAPP-A and fβ-hCG were found to be significantly lower in the PCOS group compared to control group [3]. Although there are studies on human participants in literature about the first trimester aneuploidy screening test to detect Down syndrome, to the best of our knowledge, there have been no studies related to the biochemical parameters in the second trimester aneuploidy screening test in patients with polycystic ovary syndrome. Analysis of the enzymatic steps in the synthesis of estriol, inhibin-A, and the serum levels of biochemical parameters can be recommended for pregnant women with PCOS. These biochemical parameters are also affected by multiple gestation, in vitro fertilization, maternal weight, ethnicity, smoking and parity. The validated software can make adjustments to calculate the risk of Down syndrome for these parameters. PCOS should be added to the parameters.

Perinatal Varicella Infection in the Light of the Literature: A Case Report

Amaç: Suçiçeği enfeksiyonu varisella zoster virüsünün neden olduğu, spesifik veziküler lezyonlarla seyreden viral bir hastalıktır. Gebelikte ortaya çıktığında maternal varisella pnömonisi, konjenital varisella sendromu, % 30 mortalite ile seyredebilen neonatal varisella enfeksiyonu riski nedeniyle önemlidir. Antiviral tedavi ve varisella immünglobulini (VZIG) ile morbidite ve mortalite oranlarında belirgin azalma kaydedilmiştir. Burada doğumundan 3 gün önce aktif varisella enfeksiyonu geçiren olgu literatür eşliğinde sunulmuştur.

Isolated hydatid cyst of uterine cervix: A case report

Hydatid disease is an endemic infection which can affect any organ, mainly the liver and lungs. Peritoneal echinococcosis is usually known to occur secondary to hepatic hydatid cyst rupture into the peritoneal cavity. An isolated cyst in the pelvic cavity is considered as primary only when there are no other hydatid cysts. Herein, we report an isolated pelvic‐cervical hydatid cyst which presented without any involvement of the other abdominal organs or lungs. Our patient, a 27‐year‐old woman with the primary complaints of dyspareunia and chronic pelvic pain, had thin‐walled large cystic mass originating from the cervix, diagnosed by ultrasonography. She underwent surgery with the most likely initial diagnosis of exophytic fibroid with cystic degeneration. Gynecologists should be aware of the possibility of isolated primary hydatid cyst of the pelvic cavity and should consider this condition in the differential diagnosis of cystic pelvic masses, especially in areas where the disease is endemic.