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Yutaka Higashi

Osaka University

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Publication

Featured researches published by Yutaka Higashi.

Journal of Pharmacy and Pharmacology | 1998

Biopharmaceutics: Topical Delivery of Keloid Therapeutic Drug, Tranilast, by Combined Use of Oleic Acid and Propylene Glycol as a Penetration Enhancer: Evaluation by Skin Microdialysis in Rats

Teruo Murakami; Makiko Yoshioka; Ryoko Yumoto; Yutaka Higashi; Sadayuki Shigeki; Yoshikazu Ikuta; Noboru Yata

Topical delivery of tranilast (N‐(3,4‐dimethoxycinnamoyl)anthranic acid), an inhibitor of collagen synthesis and a therapeutic drug for keloid and hypertrophic scar, was examined, in rats, with oleic acid alone or a combination of oleic acid and propylene glycol as penetration enhancer. Evaluation was by measurement of the concentration of tranilast in plasma and in the dialysate from skin microdialysis.

Journal of pharmacobio-dynamics | 1990

Dose-Dependent Pharmacokinetics and First-Pass Metabolism of Acetaminophen in Rats

Yoshito Tone; Ken'ichiro Kawamata; Teruo Murakami; Yutaka Higashi; Noboru Yata

Journal of pharmacobio-dynamics | 1983

A POSSIBLE MECHANISM OF ABSORPTION PROMOTERS

Noburu Yata; Yutaka Higashi; Teruo Murakami; Ryoko Yamajo; Whei Mei Wu; Kumiko Taku; Yumi Sasaki; Yasuko Hideshima

Journal of pharmacobio-dynamics | 1987

ROLE OF ACIDIC PHOSPHOLIPIDS IN TISSUE DISTRIBUTION OF QUINIDINE IN RATS

Akio Nishiura; Teruo Murakami; Yutaka Higashi; Noboru Yata

Journal of pharmacobio-dynamics | 1986

A possible contribution of phospholipids in tissue distribution of quinidine in rats

Akio Nishiura; Jun Higashi; Teruo Murakami; Yutaka Higashi; Noboru Yata

Journal of pharmacobio-dynamics | 1985

Enhanced rectal absorption of beta-lactam antibiotics in rat by monodesmosides isolated from pericarps of Sapindus mukurossi (Enmei-hi).

Noboru Yata; Narumi Sugihara; Ryoko Yamajo; Teruo Murakami; Yutaka Higashi; Hiroko Kimata; Keiso Nakayama; Tatsuo Kuzuki; Osamu Tanaka

Journal of pharmacobio-dynamics | 1986

Enhanced small intestinal absorption of beta-lactam antibiotics in rats in the presence of monodesmosides isolated from pericarps of Sapindus mukurossi (Enmei-hi).

Noboru Yata; Narumi Sugihara; Ryoko Yamajo; Teruo Murakami; Yutaka Higashi; Hiroko Kimata; Keiso Nakayama; Kuzuki T; Osamu Tanaka

Journal of pharmacobio-dynamics | 1991

Study on brain uptake of local anesthetics in rats.

Takenori Nakazono; Teruo Murakami; Yutaka Higashi; Noboru Yata

Journal of pharmacobio-dynamics | 1982

EFFECT OF ANESTHESIA ON DRUG DISPOSITION IN THE RAT

Yutaka Higashi; Naoko Notoji; Ryoko Yamajo; Noboru Yata

Chemical & Pharmaceutical Bulletin | 1978

Effect of Salicylate on the Binding of Sulfonamides to Bovine Serum Albumin

Yutaka Higashi; Toshiaki Nishihata; Kazuyoshi Kubo; Noboru Yata; Akira Kamada

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Noboru Yata

Osaka University

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Teruo Murakami

Hiroshima University

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Akira Kamada

Osaka University

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Ryoko Yamajo

Hiroshima University

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Akio Nishiura

Hiroshima University

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Hiroko Kimata

Hiroshima University

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Keiso Nakayama

Hiroshima University

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Narumi Sugihara

Hiroshima University

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Takenori Nakazono

Hiroshima University

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Kazuyoshi Kubo

Osaka University

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