Yutaka Ohuchi | Researchain

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Synthetic Communications | 1986

A New Convenient Synthesis of α-Arylpropionic Acid Esters and α-Arylpropionitriles

Takehiro Arnano; Kensei Yoshikawa; Tatsuhiko Sano; Yutaka Ohuchi; Manzo Shiono; Michihiro Ishiguro; Yoshiji Fujita

Abstract Various types of α-arylpropionic acid esters were effectively obtained by the coupling reaction of aryl Grignard reagents and α-bromopropionic acid esters in the presence of nickel catalysts. α-Arylpropionitriles, precursors of α-arylpropionic acids, were also synthesized by the reaction of α-methanesulfonyloxypropionitrile and arylcopper reagents prepared from equimolar amount of arylmagnesium halides and copper(I) bromide.

Archive | 1995

Quinolinecarboxylic acid derivatives

Yutaka Ohuchi; Masaji Suzuki; Hajime Asanuma; Sadakazu Yokomori; Katsuo Hatayama

Chemical & Pharmaceutical Bulletin | 2000

Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists.

Masaji Suzuki; Yutaka Ohuchi; Hajime Asanuma; Toshie Kaneko; Sadakazu Yokomori; Chika Ito; Yoshihiko Isobe; Makoto Muramatsu

Chemical & Pharmaceutical Bulletin | 2001

Synthesis and Evaluation of Novel 2-Oxo-1, 2-dihydro-3-quinolinecarboxamide Derivatives as Potent and Selective Serotonin 5-HT4 Receptor Agonists

Masaji Suzuki; Yutaka Ohuchi; Hajime Asanuma; Toshie Kaneko; Sadakazu Yokomori; Chika Ito; Yoshihiko Isobe; Makoto Muramatsu

Heterocycles | 2000

A Practical Procedure for Preparation of N-(endo-8-(3-Hydroxy)propyl-8-azabicyclo[3.2.1]oct-3-yl)-1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxamide(TS-951)

Masaji Suzuki; Toshie Kaneko; Hiroaki Kamiyama; Yutaka Ohuchi; Sadakazu Yokomori

Bulletin of the Chemical Society of Japan | 1986

Effective synthesis of 2-[4-(3-methyl-2-butenyl)phenyl]propionic acid via hydromagnesation reaction with nickel or titanium catalysts

Takehiro Amano; Tomomi Ota; Kensei Yoshikawa; Tatsuhiko Sano; Yutaka Ohuchi; Fumie Sato; Manzo Shiono; Yoshiji Fujita

Chemical & Pharmaceutical Bulletin | 1986

Synthesis and antiinflammatory activity of alkenylphenylpropionic acids.

Takehiro Amano; Kensei Yoshikawa; Toshihisa Ogawa; Tatsuhiko Sano; Yutaka Ohuchi; Tohru Tanami; Tomomi Ota; Katsuo Hatayama; Shohei Higuchi; Fusao Amanuma; Kaoru Sota

Archive | 1982