Yuting Liu

Syntheses and biological activity of chalcones-imidazole derivatives

A number of novel 13-membered chalcone-imidazole derivatives were prepared and have been synthesized and characterized by IR, 1H NMR, 13C NMR and elemental analysis, the results conformed well to expected structures. Substituted acetophenones and benzaldehydes were condensed using the Claisen–Schmidt base-catalyzed aldol condensation. Methyl on the aromatic ring of chalcones was brominated by NBS, and then the resulting mixture was reacted with imidazole to get the target compound. Several chalcones showed in vitro antibacterial activity against Gram-bacterial. The results showed that these are potential antibacterial compounds.

Synthesis and antimicrobial activity of novel mancozeb derivatives containing 1,3,4-thiadiazole

Four mancozeb derivatives containing 1,3,4-thiadiazole, 5a–5d, were successfully synthesized, then characterized by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. Their antimicrobial activity against paddy fusarium, Botrytis cinerea, cucumber fusarium, tomato gibberella, and grape white rot was tested in vitro by use of the filter paper disk-diffusion technique. Compounds 5a–5d had moderate to excellent antimicrobial activity in comparison with mancozeb, 6. Among these compounds, 5a had the best inhibitory activity.

Synthesis, Characterization and Antimicrobial Activity of Bis-Acetylferrocene Schiff Base

Three bis-acetylferrocene schiff bases have been synthesized and characterized by IR, 1H NMR, and elemental analysis, the results conformed well with expected structures. The synthesized compounds were screened in vitro for their antimicrobial activity against three Gram-negative (Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains. The results showed that these compounds are show excellent antimicrobia activities against Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi ,Bacillus subtilis,Staphylococcus aureus.

Synthesis and characterization of novel benzaldehyde derivatives containing 1,3,4-thiadiazole

In the work discussed in this paper, a series of novel benzaldehyde derivatives containing 1,3,4-thiadiazole were prepared in high yield from 4-fluorobenzaldehyde and 2-amino-5-substituted-1,3,4-thiadiazole. The products were characterized by determination of melting point, elemental analysis, and UV–visible, IR, 1H NMR, and 13C NMR spectroscopy. The fluorescence properties of the compounds were also studied by recording their fluorescence emission spectra.

Ferrocene-Based with Thiadiazole Antibacterial Agents: Synthesis, Characterization, and Biological Evaluation

A series of ferrocene schiff bases derived from Thiadiazole have been synthesized and characterized by IR, 1H NMR, and elemental analysis, the results conformed well with expected structures. The synthesized compounds were screened in vitro for their antibacterial activity against three Gram-negative (Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains. The results showed that these compounds are a series potential new drugs in antibacterial activity against one or more species.

Optimization of Synthesis Technology of Acetylferrocene by Response Surface Methodology

Acetylferrocene was synthesized by acetyl chloride and ferrocene as raw materials, dichloromethane as the solvent, and ZnO as catalyst. Response surface methodology based on three-level, three-variable central composite rotable design was used to evaluate the interactive effects of the ratio of acetyl chloride and ferrocene(2-4), the amount of ZnO(1.0-1.3mol), reaction time(30-60 min)on the percentage yield of acylferrocene. The optimal raw material ratio, amount catalyst, and reaction time was 3:1, 1.19mol, 40min. Under the optimum conditions, the actual experimental yield can reach 86.72%.

Synthesis and Antibacterial Activity of Acetyl Ferrocene Hydrazine Hydrazone and its Metal Complexes

Acetyl ferrocene hydrazine hydrazone and its novel metal complexes were synthesized. The structures were confirmed by elemental analysis, IR, molar conductance and thermo gravimetric analysis. The antibacterial activity was tests the result showed that the antibacterial activities of the complexes were significantly improved comparing with ligands.

Synthesis and Antibacterial Activity of Several Nonvel Schiff Bases Bearing Acetylferrocenyl and 2-Amino-5-Substituted-1,3,4-Thiadiazole

A series of novel schiff bases bearing acetylferrocenyl and 2amino-5-substituted -1,3,4-thiadiazole were synthesized and the structure of them were confirmed by IR, 1 H NMR and elementary analysis.The title compounds were evaluated for antibacterial activity against gram positive(Staphylococcus aureus),gram negative bacteria(Escherichia coli), fungi(Yeast) and bacteria(Actinomycete). The results of antibacterial activity test showed that all compounds possess potent antibacterial activity,especially the compound 3e. Introduction Schiff base has received much attention because of their potencial physiological activity and the prevention of fungal growth activity as anticancer, antitumor, antituberculosis agents,etc.At the same time, coordination compounds of schiff base have good inhibiting effect of O2 ,high catalytic activity and oxygen containing capability[1,2].Meanwhile,it is a series of useful schiff base derivatives containing ferrocenyl for proceeding cyclopalladated reaction[3~5] and addition reaction of C=N[6]. Medicinal chemists over the years have proceeded lots of researches. In hope of improving antitumor activities,for 1,3,4-Thiadiazoles derivatives are known to exhibits, anticancer[7,8] , antibacterial[9~11], antifungal[12,13], anticonvulsant, sedative-hypnotic and central nervous system (CNS) neurotoxicity activities[14], with being substituted different perssads at position 5 of it, 1,3,4-thiadiazoles ring was introduced into schiff base derivatives containing ferrocenyl .As a result,six novel compounds with 1,3,4-Thiadiazoles ring were synthesized and their antibacterial activities against gram positive,gram negative and fungi were reported. Chemisty The synthesis of schiff bases bearing acetylferrocenyl and 2amino-5-substituted -1,3,4-thiadiazole was accomplished as shown in Scheme 1. The synthesis of 2-amino-5-substituted-1,3,4-thiadiazole2a~f was achieved by treating carboxylic acid1a~f directly with thiosemicarbazide in the presence of phosphorus oxychloride,the target compounds3a~f were obtained by condensation of acetylferrocenyl and compouns2a~f with toluene as solution under the protection of N2. Advanced Materials Research Online: 2011-11-22 ISSN: 1662-8985, Vols. 396-398, pp 1067-1070 doi:10.4028/www.scientific.net/AMR.396-398.1067

Synthesis and Antibacterial Activity of Novel Schiff Base Containing Diacetylferrocene and 2-Amino-5-Alkyl-1,3,4-Thiadiazole

A series of novel Schiff base containing diacetylferrocene and 5-alkyl-2-amino-1,3,4 -thiodizoles were reported in this paper. Diacetylferrocene(Ⅱ) was synthesised with ferrocene(Ⅰ) and acetyl chloride with AlCl3 as catalyst in CH2Cl2. In the presence of diacetylferrocene and 5-alkyl-2-amino-1,3,4-thiodizole reacted under solvent and catalyst condition to furnish Schiff base containing diacetylferrocene and 5-alkyl-2-amino-1,3,4-thiadiazoles(Ⅲ). Chemical structures have been confirmed by elemental annalysis and the spectral techniques of FTIR,1H NMR. Antimicrobial activity (in vitro) was evaluated against the two pathogenic bacterial strains. The compounds have shown better activity.

Ferrocene-Based Antibacterial Agents: Synthesis, Characterization, and Biological Evaluation of Metal (II) Complexes with Glycine-Derived Compounds

A series of Ferrocene Schiff bases derived from glycine and their cobalt (II), copper (II), nickel (II), and zinc (II) metal complexes have been synthesized and characterized by IR, 1H NMR, MS and elemental analysis, the results conformed well with expected structures. The synthesized ligands, along with their metal (II) complexes, were screened in vitro for their antibacterial activity against three Gram-negative (Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains. The results showed that the metal (II) complexes are more potent in antibacterial activity against one or more species in comparison with those of uncomplexed ligands.