Yuyoung Lee

Ginsenoside-Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells

In this paper, we present evidence that ginsenoside-Rs4 (G-Rs4; an acetylated analogue of ginsenoside-Rg5), a new ginseng saponin isolated from Panax ginseng C. A. Meyer, elevates protein levels of p53 and p21WAF1, which are associated with the induction of apoptosis in SK-HEP-1 cells. Flow cytometric analyses showed that G-Rs4 initially arrested the cell cycle at the G1/S boundary, but consequently induced apoptosis as evidenced by generating an apoptotic peak. The induction of apoptosis was confirmed by the results of DNA fragmentation assays and alterations in cell morphology after treatment of the cells with G-Rs4. Immunoblot assays showed that G-Rs4 significantly elevated protein levels of p53 and p21WAF1, concurrently with the downregulation of both cyclins E- and A-dependent kinase activities and induction of apoptosis. We suggest that G-Rs4 induces apoptosis, the effect of which is closely related to the downregulation of both cyclins E- and A-dependent kinase activity as a consequence of selectively elevating protein levels of p53 and p21WAF1 in SK-HEP-1 cells.

Tectonic evolution of Precambrian basement massifs and an adjoining fold-and-thrust belt (Gyeonggi Marginal Belt), Korea: An overview

This contribution provides an overview on geology, geochronology, and tectonics of Precambrian basement massifs and adjoining Gyeonggi Marginal Belt (GMB), Korea. The three massifs (Gyeonggi, Yeongnam, and Nangrim) record tectonothermal events represented by ∼2.0–1.85 Ga arc-related magmatism and collisional orogenesis, culminating at ∼1.88–1.85 Ga. The oldest (∼2.51 Ga) migmatitic gneisses limitedly occur in the Nangrim and Gyeonggi massifs, suggesting the North China Craton (NCC) affinity of both massifs. The Yeongnam Massif is characterized by the occurrence of ∼1.87–1.86 Ga anorthosite-mangerite-charnockite-granite suite. This anorthositic suite is a late-orogenic product linked to the amalgamation of ‘Paleoproterozoic Korean arc’ with the North China Craton, forming the Columbia/Nuna supercontinent. The majority of Hf and Nd model ages of basement gneisses are in the range of ∼3.5–2.5 Ga, attesting to the crustal evolution since the Paleoarchean. P-T paths of the Paleoproterozoic basement gneisses are apparently variable, and the Gyeonggi and Yeongnam massifs are characterized by the kyanite-sillimanite and andalusite-sillimanite facies types, respectively. The GMB comprises three fold-and-thrust sub-belts (Imjingang Belt, Taean–Hongseong Complex, and Ogcheon Metamorphic Belt) which are correlative with each other in terms of tectonostratigraphy and detrital zircon geochronology. Two (meta)sedimentary units are diagnostic of this belt: (1) the Neoproterozoic Sangwon Supergroup sharing the provenance with younger rocks in the Ogcheon Belt; and (2) the Devonian turbiditic sequences present in all the three sub-belts. The latter are most distinctive in their detrital zircon age distribution characterized by two major populations at ∼1000–950 Ma and 450–430 Ma. This age pattern as well as the turbiditic lithology is critical for the correlation between the GMB and the Qinling Belt. Taken together, we suggest that the South China Craton-like GMB units are built upon the NCC-like basement (Gyeonggi Massif); this feature is the key to the Qinling–Gyeonggi microcontinent model which accounts for the assembly of a variety of tectonic slivers in the GMB.

A cryptic species of Aphis gossypii (Hemiptera: Aphididae) complex revealed by genetic divergence and different host plant association.

Three cryptic species, Aphis gossypii, Aphis glycines, and Aphis rhamnicola sp. nov., are recognized as sharing buckthorn plant, Rhamnus spp. as primary hosts. These aphid species have morphological similarities; however, there are significant genetic differences between the three cryptic species. Based on the high level of genetic divergence and the different secondary host association, we described a new species, Aphis rhamnicola sp. nov., for apterous and alate vivipara, fundatrix, ovipara, and gynopara, including diagnostic key for the host sharing species in the genus Aphis.

Paleoseismological implications of liquefaction-induced structures caused by the 2017 Pohang Earthquake

During and shortly after the 2017 Pohang Earthquake (Mw 5.4), sand blows were observed around the epicenter for the first time since the beginning of instrumental seismic recording in South Korea. We carried out field surveys plus satellite and drone imagery analyses, resulting in observation of approximately 600 sand blows on Quaternary sediment cover in this area. Most were observed within 3 km of the epicenter, with the farthest being 15 km away. In order to investigate the ground’s susceptibility to liquefaction, we conducted a trench study of a 30 m-long sand blow in a rice field 1 km from the earthquake epicenter. The physical characteristics of the liquified sediments (grain size, impermeable barriers, saturation, and low overburden pressure) closely matched the optimum ground conditions for liquefaction. Additionally, we found a series of soft sediment deformation structures (SSDSs) within the trench walls, such as load structures and water-escaped structures. The latter were vertically connected to sand blows on the surface, reflecting seismogenic liquefaction involving subsurface deformation during sand blow formation. This genetic linkage suggests that SSDS research would be useful for identifying prehistoric damage-inducing earthquakes (Mw > 5.0) in South Korea because SSDSs have a lower formation threshold and higher preservational potential than geomorphic markers formed by surface ruptures. Thus, future combined studies of Quaternary surface faults and SSDSs are required to provide reliable paleoseismological information in Korea.