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Dive into the research topics where Yvo Crameri is active.

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Featured researches published by Yvo Crameri.


Tetrahedron-asymmetry | 1991

New efficient methods for the synthesis and in-situ preparation of ruthenium(II) complexes of atropisomeric diphosphines and their application in asymmetric catalytic hydrogenations

Bernd Heiser; Emil Albin Broger; Yvo Crameri

Abstract A new synthetically useful method for the synthesis of the diphosphine ruthenium dicarboxylato complexes (PP)Ru(O2CR)2 (R = CF3 and CH3) is presented, which uses the easily accessible complex (COD)2Ru2(μ-O2CCF3)4 as starting material. This complex as well as (COD)Ru(η2-O2CCH3)2 and (COD)2Ru2Cl4(NCCH3) have been shown to be suitable precursor complexes for the in-situ preparation of ruthenium(II) dicarboxylato and dichloro complexes of atropisomeric diphosphines, respectively. The high efficacy of the preformed and in-situ generated ruthenium complexes as precatalysts is demonstrated in asymmetric hydrogenations of allylic alcohols, enamides, and a β-keto ester.


Tetrahedron-asymmetry | 1997

Practical synthesis of (S)-2-(4-fluorophenyl)-3-methylbutanoic acid, key building block for the calcium antagonist Mibefradil

Yvo Crameri; Joseph Foricher; Michelangelo Scalone; Rudolf Schmid

Abstract A short, technically feasible route was developed for the synthesis of (S)2-(4-fluorophenyl)-3-methylbutanoic acid (S)- 2 with an overall yield of 80% starting from 4-fluorophenylacetic acid. Asymmetric hydrogenation of the easily accessible unsaturated acid 3 in the presence of ruthenium(II) carboxylato complexes containing chiral atropisomeric diphosphines afforded (S)- 2 in up to 94% ee. The ee of (S)- 2 was upgraded to 98% by crystallization of its sodium salt. The same protocol was also applied to the synthesis of (S)-2-(4-chlorophenyl)-3-methylbutanoic acid.


Pure and Applied Chemistry | 1996

New developments in enantioselective hydrogenation

Rudolf Schmid; Emil Albin Broger; Marco Cereghetti; Yvo Crameri; Joseph Foricher; Michel Lalonde; R. K. Müller; Michelangelo Scalone; G. Schoettel; Ulrich Zutter


Helvetica Chimica Acta | 1988

Optically pure isoproterenol analogues with side chains containing an amide bond: synthesis and biological properties

Hans Peter Märki; Yvo Crameri; Rainer Eigenmann; Anna Krasso; Henri Ramuz; Karl Bernauer; Murray Goodman; Kenneth L. Melmon


Archive | 1985

Chiral rhodium-diphosphine complexes for asymmetrical hydrogenation

Emil Albin Broger; Yvo Crameri


Archive | 1979

Process for the preparation of cyclohexenyl derivatives, and intermediates produced in the synthesis

Emil Albin Broger; Yvo Crameri; Hans Georg Wilhelm Leuenberger; Erich Widmer; Reinhard Zell


Archive | 1985

Chiral rhodium-diphosphine complexes

Emil Albin Broger; Yvo Crameri


Archive | 1983

Rhodium complexes of chiral phosphines

Emil Albin Broger; Yvo Crameri


Archive | 1995

Process for the enantioselective hydrogenation of ketosiophorone derivatives

Emil Albin Broger; Yvo Crameri; Rudolf Schmid; Theodor Siegfried


Archive | 1988

Isoquinoline derivatives, their manufacture and use

Emil Albin Broger; Yvo Crameri; Bernd Heiser

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