Yvon Gauthier
University of Bordeaux
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Publication
Featured researches published by Yvon Gauthier.
Pigment Cell & Melanoma Research | 2012
Khaled Ezzedine; Henry W. Lim; Tamio Suzuki; Ichiro Katayama; Iltefat Hamzavi; Cheng-Che E. Lan; Boon‐Kee Goh; Tag S. Anbar; C. Silva de Castro; Ai-Young Lee; Davinder Parsad; N. van Geel; I. C. Le Poole; Naoki Oiso; Laila Benzekri; Richard A. Spritz; Yvon Gauthier; S. K. Hann; M. Picardo; Alain Taïeb
During the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: classification and nomenclature; definition of stable disease; definition of Koebner’s phenomenon (KP); and ‘autoimmune vitiligo’. These topics were discussed in seven working groups representing different geographical regions. A consensus emerged that segmental vitiligo be classified separately from all other forms of vitiligo and that the term ‘vitiligo’ be used as an umbrella term for all non‐segmental forms of vitiligo, including ‘mixed vitiligo’ in which segmental and non‐segmental vitiligo are combined and which is considered a subgroup of vitiligo. Further, the conference recommends that disease stability be best assessed based on the stability of individual lesions rather than the overall stability of the disease as the latter is difficult to define precisely and reliably. The conference also endorsed the classification of KP for vitiligo as proposed by the VETF (history based, clinical observation based, or experimentally induced). Lastly, the conference agreed that ‘autoimmune vitiligo’ should not be used as a separate classification as published evidence indicates that the pathophysiology of all forms of vitiligo likely involves autoimmune or inflammatory mechanisms.
Journal of The American Academy of Dermatology | 1992
Yvon Gauthier; Jean-Etienne Surleve-Bazeille
BACKGROUND Achromic lesions on the trunk and the extremities often do not respond to treatment and little improvement is obtained in cases of segmental vitiligo. OBJECTIVE Transplantation of autologous noncultured melanocytes was performed to obtain a successful repigmentation. METHODS The grafting method is carried out in two steps: production of blisters on the depigmented lesions by freezing with liquid nitrogen and injection in each blister of a suspension of epidermal cells (mainly keratinocytes and melanocytes). The cellular suspension was obtained from samples of skin of the hair scalp after trypsinization. RESULTS Repigmentation was evident within 25 to 30 days. Coalescence of the pigmented areas was spontaneously observed or obtained after UVA stimulation. Patients with two types of leukoderma-vitiligo or nevus depigmentosus had successful repigmentation after transplantation of autologous noncultured melanocytes. CONCLUSION This technique appears to be an effective and simple method for treating patients with achromic areas lacking melanocytes.
British Journal of Dermatology | 2013
Alain Taïeb; A. Alomar; Markus Böhm; M.L. Dell’Anna; A. De Pase; Viktoria Eleftheriadou; Khaled Ezzedine; Yvon Gauthier; David J. Gawkrodger; Thomas Jouary; Giovanni Leone; Silvia Moretti; L. Nieuweboer‐Krobotova; M.J. Olsson; Davinder Parsad; T. Passeron; A. Tanew; W. van der Veen; N. van Geel; Maxine Whitton; A. Wolkerstorfer; M. Picardo
The aetiopathogenic mechanisms of vitiligo are still poorly understood, and this has held back progress in diagnosis and treatment. Up until now, treatment guidelines have existed at national levels, but no common European viewpoint has emerged. This guideline for the treatment of segmental and nonsegmental vitiligo has been developed by the members of the Vitiligo European Task Force and other colleagues. It summarizes evidence‐based and expert‐based recommendations (S1 level).
British Journal of Dermatology | 2003
Yvon Gauthier; Muriel Cario-André; S. Lepreux; Catherine Pain; Alain Taieb
Background In vitiligo, melanocytes are gradually lost in depigmented macules of the skin. The disappearance of melanocytes has, however, not been clearly observed and consequently the aetiology of the disease (autoimmune, neural, cytotoxic) is still elusive. The starting point of vitiligo macules is frequently determined by local conditions such as wounds and excoriations, but may also follow minor traumas such as pressure or repeated friction. This prominent feature is often neglected.
Journal of The American Academy of Dermatology | 2011
Khaled Ezzedine; Yvon Gauthier; Christine Léauté-Labrèze; Sonia Marquez; Serge Bouchtnei; Thomas Jouary; Alain Taïeb
BACKGROUND Mixed vitiligo (MV), the association of segmental vitiligo (SV) and nonsegmental vitiligo, has been rarely reported. OBJECTIVE The aim of this study was to delineate the clinical spectrum of MV through a case series of patients with typical SV associated with patchy bilateral vitiligo. METHODS This was a cross-sectional evaluation in the setting of a prospective observational study conducted in the vitiligo clinic of the department of dermatology in Bordeaux, France. RESULTS Nineteen patients with MV were identified. Four were male and 15 were female. Most patients had an onset of SV before the age of 18 years (18 of 19). In all patients, SV preceded nonsegmental vitiligo with a delay ranging from 6 months to more than 24 months. LIMITATIONS This study was cross-sectional and based on a single-center experience. CONCLUSION MV is not yet part of a conventional classification. However, this entity may have been neglected until now and should be included in the classification of vitiligo in addition to SV and nonsegmental vitiligo. Moreover, MV may be essential to the understanding of the pathogenesis of vitiligo as a primary skin disorder.
Pigment Cell & Melanoma Research | 2008
Alain Taïeb; Fanny Morice-Picard; Thomas Jouary; Khaled Ezzedine; Muriel Cario-André; Yvon Gauthier
Clinical findings in vitiligo challenge the widely accepted organ specific autoimmune pathomechanisms. We draw the attention to the fact that the distribution of segmental vitiligo (SV) fits in at least a subset of patients a pattern usually associated with cutaneous mosaicism. The association of SV to non‐segmental vitiligo (NSV) now confirmed by several observations indicates a continuum between the two subsets with shared predisposing genetic factors, including genes operating specifically in the skin. Some pedigrees associating SV and NSV further suggest a mechanism of loss of heterozygosity for a dominant gene controlling part of the cutaneous phenotype. The mosaic hypothesis applies only to SV and to the rare SV‐NSV association, but suggests that predisposing genetic factors in common NSV should also be searched directly in the skin. SV would be a good candidate disease to explore as a proof of principle of a new gene discovery strategy useful for multigenic disorders with organ specificity, applicable in priority to chronic inflammatory skin disorders.
Pigment Cell & Melanoma Research | 2011
Nanja van Geel; Reinhart Speeckaert; Alain Taïeb; Mauro Picardo; Markus Böhm; David J. Gawkrodger; Karin Schallreuter; Dorothy C. Bennett; Wietze van der Veen; Maxine Whitton; Silvia Moretti; Wiete Westerhof; Khaled Ezzedine; Yvon Gauthier
Koebner’s phenomenon (KP) has been observed in a number of skin diseases, including vitiligo. Its clinical significance in vitiligo with respect to disease activity and course is still debatable, while its relevance for surgical techniques has been demonstrated in some reports. We present a literature review on the currently known facts about KP in vitiligo, including details of clinical, experimental, and histopathological changes. The consensus view is that there are still no methods to define and assess KP in vitiligo. A new classification is proposed to allow an evaluation of KP in daily practice or in experimental studies. However, many unanswered questions still remain after redefining KP in patients with vitiligo. Active research focusing on KP in vitiligo may not only provide unexpected clues in the pathogenesis of vitiligo but also help to tailor novel therapies against this chronic and often psychologically devastating skin disease.
Pigment Cell & Melanoma Research | 2015
Viktoria Eleftheriadou; Kim S Thomas; Nanja van Geel; Iltefat Hamzavi; Henry Lim; Tamio Suzuki; Ichiro Katayama; Tag S. Anbar; Marwa Abdallah; Laila Benzekri; Yvon Gauthier; John E. Harris; Caio Cesar Silva de Castro; Amit G. Pandya; Boon Kee Goh; Cheng-Che E Lan; Naoki Oiso; Ahmed Al Issa; Samia Esmat; Caroline Le Poole; Ai-Young Lee; Davinder Parsad; Alain Taïeb; Mauro Picardo; Khaled Ezzedine
1 Centre of Evidence Based Dermatology, University of Nottingham, Nottingham,UK 2 Department of Dermatology, Ghent University Hospital, Ghent, Belgium3 Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA4 Department of Dermatology, Yamagata University School of Medicine,Yamagata, Japan 5 Department of Dermatology, Osaka University, Osaka, Japan6 Dermatology Department, Al-Minya University, Al-Minya, Egypt 7 Departmentof Dermatology and Venereology, Ain Shams University, Cairo, Egypt8 Department of Dermatology, Ibn Sina University Hospital, Rabat, Morocco9 Mohammed V Souissi University, Rabat, Morocco 10 Department ofDermatology, University of Bordeaux National Reference Centre for Rare SkinDiseases H^opital St-Andr e, Bordeaux, France 11 Department of Medicine,Division of Dermatology, University of Massachusetts Medical School,Worcester, MA, USA 12 Department of Dermatology, Pontifcia UniversidadeCatœlica do Paranffi, Curitiba, Brazil 13 Department of Dermatology, University ofTexas Southwestern Medical Center, Dallas, TX, USA 14 National Skin Centre,Singapore City, Singapore 15 Department of Dermatology, Kaohsiung MedicalUniversity, Kaohsiung City, Taiwan 16 Department of Dermatology, KinkiUniversity Faculty of Medicine, Osaka-Sayama, Japan 17 Vitiligo Light Clinic,Riyadh, Saudi Arabia 18 Department of Dermatology, Cairo University, Kasr AlAiny Hospital, Cairo, Egypt 19 Departments of Pathology, Microbiology andImmunology/Oncology Institute, Loyola University Chicago, Chicago, IL, USA20 Department of Dermatology, Dongguk University Ilsan Hospital, Gyeonggi-do,Korea 21 Department of Dermatology, PGIMER, Chandigarh, India 22 Departmentof Dermatology, San Gallicano Dermatologic Institute IRCCS, Roma, ItalyCORRESPONDENCE Khaled Ezzedine and Viktoria Eleftheriadou, e-mails: [email protected]; [email protected]
Journal of Investigative Dermatology | 2015
Roselyne Y. Wagner; Flavie Luciani; Muriel Cario-André; Alain Rubod; Valérie Petit; Laila Benzekri; Khaled Ezzedine; Sebastien Lepreux; Eirikur Steingrimsson; Alain Taïeb; Yvon Gauthier; Lionel Larue; Véronique Delmas
Vitiligo is the most common depigmenting disorder resulting from the loss of melanocytes from the basal epidermal layer. The pathogenesis of the disease is likely multifactorial and involves autoimmune causes, as well as oxidative and mechanical stress. It is important to identify early events in vitiligo to clarify pathogenesis, improve diagnosis, and inform therapy. Here, we show that E-cadherin (Ecad), which mediates the adhesion between melanocytes and keratinocytes in the epidermis, is absent from or discontinuously distributed across melanocyte membranes of vitiligo patients long before clinical lesions appear. This abnormality is associated with the detachment of the melanocytes from the basal to the suprabasal layers in the epidermis. Using human epidermal reconstructed skin and mouse models with normal or defective Ecad expression in melanocytes, we demonstrated that Ecad is required for melanocyte adhesiveness to the basal layer under oxidative and mechanical stress, establishing a link between silent/preclinical, cell-autonomous defects in vitiligo melanocytes and known environmental stressors accelerating disease expression. Our results implicate a primary predisposing skin defect affecting melanocyte adhesiveness that, under stress conditions, leads to disappearance of melanocytes and clinical vitiligo. Melanocyte adhesiveness is thus a potential target for therapy aiming at disease stabilization.
British Journal of Dermatology | 2011
Khaled Ezzedine; A. Diallo; Christine Léauté-Labrèze; Djavad Mossalayi; Yvon Gauthier; S. Bouchtnei; Muriel Cario-André; Julien Seneschal; F. Boralevi; Thomas Jouary; Alain Taïeb
Background Although mixed forms have been described recently, segmental (SV) and nonsegmental vitiligo (NSV) are considered as clinically distinct. However, limited epidemiological data are available to help distinguish associated factors, and recent genome‐wide association studies have been restricted to NSV. The higher prevalence of SV in children is helpful when comparing the two major presentations of the disease.
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Post Graduate Institute of Medical Education and Research
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