Z.Z.R. Hamady

Effect of type of resection on outcome of hepatic resection for colorectal metastases.

Non‐anatomical liver resections have become more common in the management of colorectal liver metastases. This study examined survival and patterns of recurrence following surgery for colorectal liver metastases.

Hepatic Resection for Colorectal Metastasis: Impact of Tumour Size

Many colorectal liver metastasis patients are denied surgical resection on the basis of tumour size. The aim of this study was to explore the impact of metastasis size on modern liver resection. Using a prospectively collected database, this was a retrospective analysis of 484 consecutive patients who underwent liver resection for colorectal liver metastases between 1993 and 2003. The cohort was divided into two groups: smaller metastases (<8xa0cm) and larger metastases (≥ 8xa0cm). Those with larger metastases were then further stratified into big metastases (8–12xa0cm) and giant metastases (>12xa0cm). Demographic, pathological, surgical technique and outcome data were compared between the groups. There were 88 (18%) patients with metastases measuring 8xa0cm or larger. There was an association between higher carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9 levels and larger metastases. The actuarial 5-year survival for patients with larger metastases was 38% compared with 42% for smaller metastases (not statistically significant). Patients with giant metastases had poorer overall and disease-free survival (both nonsignificant) compared with those with big metastases: 29% and 28% at 5 years, respectively. Patients with colorectal liver metastasis greater than 8xa0cm and up to 12xa0cm in size should not be treated differently from those with smaller lesions.

Intermittent Pringle manoeuvre is not associated with adverse long-term prognosis after resection for colorectal liver metastases.

Intermittent clamping of the porta hepatis, or the intermittent Pringle manoeuvre (IPM), is often used to control inflow during parenchymal liver transection. The aim of this study was to determine whether IPM is associated with an adverse long‐term outcome after liver resection for colorectal liver metastasis (CRLM).