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Featured researches published by Zafar Ali.


Asian Pacific Journal of Cancer Prevention | 2012

Diagnostic Accuracy, Sensitivity, Specificity and Positive Predictive Value of Fine Needle Aspiration Cytology (FNAC) in Intra Oral Tumors

Munazza Gillani; Farhan Akhtar; Zafar Ali; Irum Naz; Muhammad Atique; Muhammad Tahir Khadim

OBJECTIVE The objective of this study was to establish the diagnostic accuracy, specificity and sensitivity of fine needle aspiration cytology(FNAC) for intra-oral tumors, comparing with histopathology as the gold standard. MATERIALS AND METHODS Forty cases of FNA cytology from intraoral tumors was performed in AFID along with the demographic data and clinical information and then diagnosed at AFIP, Rawalpindi. Then the cytology results obtained per FNAC were compared with the histopathological biopsy results of the same lesions. The following variables were recorded for each patient: Age, gender, site of biopsy, diagnosis. The data were entered and analyzed using Open-epi version 2.0. Diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value were calculated. Cohen Kappa was further applied to compare the agreement between the biopsy and FNAC diagnoses. A p-value of <0.05 was considered as statistically significant. RESULTS Among the total patients included in the study there were 24 males and 16 females, with a ratio of 1.5:1. Age of the patients ranged from 24 to 80 years with a mean of 52 years. A total of six sites were aspirated from the oral cavity with maximum (11) aspirates taken from alveolar ridge. The results of FNAC revealed that there were 32 malignant and 8 benign aspirates. Confirmation through histopathological analysis came for 31/32 malignant cases while one was falsely given positive for malignancy on FNAC. Among a total of 40 cases, 31(77%) cases diagnosed were found to be malignant and remaining 9(23%) were benign. The FNAC results revealed 32 malignant and 8 benign lesions. Histopathology of the subsequent surgically excised specimen showed malignant lesions in 31(77%) and benign in 9(23%) patients. As a whole, it was found that the absolute sensitivity for intra oral FNAC was 100% and specificity 89% with positive predictive value of 97% and negative predictive value of 100%. CONCLUSION Cytological diagnosis was almost corroborative with final histopathological diagnosis in all cases, with very few exceptions, exhibiting high diagnostic accuracy.


Indian Journal of Human Genetics | 2011

Molecular investigation of mental retardation locus gene PRSS12 by linkage analysis

Zafar Ali; Masroor Ellahi Babar; Jamil Ahmad; Muhammad Zubair Yousaf; Muhammad Asif; Sajjad Ali Shah

The present study was carried out to determine the prevalence of families having mental retardation in Pakistani population. We enrolled seven mentally retarded (MR) families with two or more affected individuals. Family history was taken to minimize the chances of other abnormalities. Pedigrees were drawn using the Cyrillic software (version 2.1). The structure of pedigrees shows that all the marriages are consanguineous and the families have recessive mode of inheritance. All the families were studied by linkage analysis to mental retardation locus (MRT1)/gene PRSS12. Three STR markers (D4S191, D4S2392, and D4S3024) in vicinity of mental retardation (MR) locus (MRT1)/gene PRSS12 were amplified on all the sample of each family by PCR. The PCR products were then genotyped on non denaturing polyacrylamide gel electrophoresis (PAGE). The Haplotype were constructed to determine the pattern of inheritance and also to determine that a family was linked or unlinked to gene PRSS12. One out of the seven families was potentially linked to gene PRSS12, while the other six families remain unlinked.


Jcpsp-journal of The College of Physicians and Surgeons Pakistan | 2018

An Unusual Presentation Of Langerhans Cell Histiocytosis

Usama Rehman; Zafar Ali; Nadira Mamoon

Langerhans cell histiocytosis (LCH) is a rare entity formerly known as eosinophilic granuloma. It is characterised by clonal multiplication of langerhans cells (LCs) that can occur anywhere in the body, especially in connective tissue of skin, lymph nodes and bone. Although rare, the disorder frequently affects children. A 7-year male child presented with the complaint of swelling at glabella. CT-scan revealed a defect in the middle of both frontal bones with brain herniating out of it. The clinical differential diagnosis included osteomyelitis, Tuberculosis and encephalocele. Fine needle aspiration cytology (FNAC) was performed and diagnosis of LCH was confirmed by typical cytological features, followed by immuno- histochemical staining for CD1a.


Indian Journal of Human Genetics | 2012

The study of gene GJB2/DFNB1 causing deafness in humans by linkage analysis from district Peshawar.

Zafar Ali; Masroor Ellahi Babar; Jamil Ahmad; Sajjad Ali Shah

Families with at least 2 or more individuals having hereditary hearing loss were enrolled from different areas of Khyber Pakhtoonkhwa, mainly from district Peshawar. Detailed history was taken from each family to minimize the presence of other abnormalities and environmental causes for deafness. Families were questioned about skin pigmentation, hair pigmentation, and problems relating to balance, vision, night blindness, thyroid, kidneys, heart, and infectious diseases like meningitis, antibiotic usage, injury, and typhoid. The pedigree structures were based upon interviews with multiple family members, and pedigrees of the enrolled families were drawn using Cyrillic program (version 2.1). All families showed recessive mode of inheritance. I studied 8 families of these 10. For linkage analyses, studies for DFNB1 locus, 3 STR markers (D13S175, D13S292, and D13S787) were genotyped using polyacrylamide gel electrophoresis (PAGE) and haplotypes were constructed to determined, linkage with DFNB1 locus. From a total of 8 families, a single family-10 showed linkage to DFNB1 locus.


Asian Pacific Journal of Cancer Prevention | 2011

Diagnostic challenges and role of immunohistochemistry in metastatic liver disease.

Muhammad Tahir Khadim; Shahid Jamal; Zafar Ali; Farhan Akhtar; Muhammad Atique; Bushra Ayaz


Asian Pacific Journal of Cancer Prevention | 2010

Epidemiological and Excision Margin Status of Basal Cell Carcinoma - Three Years Armed Forces Institute of Pathology Experience in Pakistan

Muhammad Asif; Nadira Mamoon; Zafar Ali; Farhan Akhtar


Archive | 2011

Extraskeletal Soft Tissue Chondromas of Head and Neck Region

Muhammad Tahir Khadim; Muhammad Asif; Zafar Ali


Journal of Pakistan Medical Association | 2011

Intraspinal Neurenteric Cyst — a rare entity

Muhammad Tahir Khadim; Muhammad Asif; Zafar Ali


Asian Pacific Journal of Cancer Prevention | 2011

Determination of HER-2/neu by Chromogenic in Situ Hybridization on Borderline (2+) Immunohistochemistry Cases in Carcinoma Breast

Muhammad Asif; Muhammad Tahir Khadim; Sajid Mushtaq; Nadira Mamoon; Farhan Akhtar; Zafar Ali


Journal of Pakistan Medical Association | 2017

A retrospective study of clinico-pathological characteristics of colonic polyps in adults seen at a tertiary care centre

Asim Qureshi; Sara Al Shihi; Zafar Ali; Asem Shalaby

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Muhammad Tahir Khadim

Armed Forces Institute of Pathology

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Nadira Mamoon

Armed Forces Institute of Pathology

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Asim Qureshi

Aga Khan University Hospital

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Jamil Ahmad

Balochistan University of Information Technology

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Masroor Ellahi Babar

University of Veterinary and Animal Sciences

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Sajjad Ali Shah

University of Veterinary and Animal Sciences

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Muhammad Zubair Yousaf

University of Veterinary and Animal Sciences

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Sajid Mushtaq

Armed Forces Institute of Pathology

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Shahid Jamal

Armed Forces Institute of Pathology

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