Zbigniew A. Proba

Nitrate ion as catalyst for selective silylations of nucleosides

Abstract Nitrate ion has been found to have a remarkable effect on the selectivity of silylation of ribonucleosides using the t -butyldimethylsilyl group.

High yield selective 3′-silylation of ribonucleosides

Abstract Procedures have been developed which permit the highly selective silylation of the 3′-hydroxyl of ribonucleosides to produce 3′,5′-diprotected derivatives in high yields.

N-levulination of nucleosides

Abstract Procedures have been developed for the synthesis of the N-levulinyl derivatives of cytidine, adenosine and guanosine.

Silylated derivatives of arabinonucleosides

Abstract Procedure have been developed which allow for the selective derivatization of arabinonucleosides at the 5′− or 2′− and 5′− or 3′− and 5′− positions.

Conversion of ribonucleosides to protected 3′-deoxynucleosides

Abstract A procedure is presented for the conversion of ribonucleosides to 3′-deoxyribonucleosides and their protected derivatives.

Synthesis of Purine and Pyrimidine Trihydroxyacyclonucleosides

Abstract The [[3-hydroxy-2-bis(hydroxymethyl)-l-propoxy]methyl] derivatives of adenine, guanine, cytosine and thymine have been synthesized and tested against herpesviruses.

Acyclic Nucleosides Containing Two Heterocyclic Bases

Abstract A new series of acyclic nucleoside derivatives is described which contain two purine or pyrimidine rings (or a combination) attached to glycerol. The analogues described have been tested for activity against herpesviruses and were found to be inactive.