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Featured researches published by Zeinab A. Hozien.


Bioorganic & Medicinal Chemistry | 2001

Synthesis, characterization and reactions of 2-deoxo-5-deazaalloxazines

Abd El-Wareth A. O. Sarhan; Zeinab A. Hozien; Hosney A.H. El-Sherief

5-Deazaflavins and their homologues have been known as potential riboflavin antagonists, bioreductives, and compounds with potent antitumor activity. 2-Amino-4-methylquinoline-3-carbonitrile (2) was prepared as unreported starting material for several interesting 2-deoxo-5-deazalloxazine derivatives. Cyclization of 2 using formamide afforded the 2,4-deoxo-5-deazaalloxazine derivative 7, which was subjected to deamination with nitrous acid to give the 2-deoxo-5-deazaalloxazine (8). The compound 8 was also obtained via 13 by treating the latter with refluxing formic acid or formamide and used as a precursor for synthesis of several 2-deoxo-5-deazaalloxazines 18, 19, 20, 21 and 22. The pharmacological and biological properties of these compounds are still under investigation.


Journal of Chemical Research-s | 2000

Intramolecular Mannich reaction for synthesis of imidazo-[2,1-b]-1,3,5-thiadiazines and 1,2,4-triazino[3,2,-b]-1,3,5-thiadiazines

Zeinab A. Hozien

New imidazo[2,1-b]-1,3,5-thiadiazines and 1,2,4-triazino[3,2,-b]-1,3,5-thiadiazines, which have been prepared in good yields under Mannich reaction conditions. The antibacterial activity of some compounds have been evaluated.


Zeitschrift für Naturforschung B | 1997

A Convenient One-Pot Synthesis of Pyrazolo[3,4-d]pyrimidines and s-Triazolo[3,4-b][1,3,5]thiadiazines

Zeinab A. Hozien; Abd El-Wareth A. O. Sarhan; H. A. H. El-Sherief; A. M. Mahmoud

Abstract The reaction of 5-amino-3-aryl-1-phenylpyrazoles (1a-d) with formaldehyde and secondary amines in boiling ethanol gave the corresponding 4-alkylaminomethyl derivatives (2a-f) and bis-(4-pyrazolyl)methane (4a,b) as byproduct. Such reaction with primary aliphatic and aro matic amines at room temperature afforded 1,3,5-trisubstituted (5a-h) and 1,3.5,7-tetrasubstituted tetrahydropyrazolo[3,4-d]pyrimidines (8a-k) respectively in good yield. Similarily, the Mannich reaction of 5-mercapto-3-phenyl-1,2,4-triazole (9) with secondary amines, in boiling ethanol, and primary aromatic amines, at room temperature, gave 2 -substituted aminomethyl derivatives (10a-c) and (14a-g) respectively,while with primary aliphatic amines, p-toluidine and p-anisidine,at room temperature,and with other primary aromatic amines, in boiling ethanol, afforded the cyclized products 12,4-triazolo[3,4-b]thiadiazines (13a-e); (15f,g) and (15a-e), respectively.


Tetrahedron | 2011

Photochromism of dihydroindolizines. Part 16: Tuning of the photophysical behavior of photochromic dihydroindolizines in solution and in polymeric thin film

Saleh A. Ahmed; Zeinab A. Hozien; Aboel-Magd A. Abdel-Wahab; Shaya Y. Al-Raqa; Abdulrahman A. Al-Simaree; Ziad Moussa; S.N. Alamri; Mouslim Messali; Ahmed S. Soliman; Heinz Dürr


Journal of Heterocyclic Chemistry | 2000

An efficient route for synthesis of 5,6‐diphenylimidazo‐[2,1‐b]thiazoles as antibacterial agents

Zeinab A. Hozien; A. O. Sarhan Abd El-Wareth; H. A. H. El-Sherief; A. M. Mahmoud


Tetrahedron Letters | 2012

Photochromism of dihydroindolizines. Part XVIII: palladium-catalyzed Negishi coupling for the synthesis of photochromic dihydro 5-azaindolizine-linker-conjugates with a terminal ethylene anchoring group

Saleh A. Ahmed; Khalid S. Khairou; Aboel-Magd A. Abdel-Wahab; Zeinab A. Hozien; Heinz Dürr


Arkivoc | 2011

One pot synthesis and reactions of novel 5-amino[1,3]thiazolo[3,2-b][1,2,4]triazoles

H. A. H. El-Sherief; Zeinab A. Hozien; Ahmed F. M. El-Mahdy; A. A. O. Sarhan


Collection of Czechoslovak Chemical Communications | 1993

Synthesis of some new spirothiazolidinones incorporated with quinazoline moiety

Zeinab A. Hozien; Abd El-Hamid N. Ahmed; Maher F. El-Zohry


Journal of Chemical Technology & Biotechnology | 2007

Synthesis of some new heterocyclic systems derived from 2‐acetylbenzimidazole

Zeinab A. Hozien


Journal of Heterocyclic Chemistry | 2010

Intramolecular cyclization of Mannich reaction for synthesis of pyrimido[2,1‐b]‐1,3,5‐tiadiazines

H. A. H. El-Sherief; Zeinab A. Hozien; Ahmed F. M. El-Mahdy; Abdelwarth A. O. Sarhan

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