Zhang Junping

Therapeutic Potential and Effective Components of the Chinese Herb Gardeniae Fructus in the Treatment of Senile Disease

Gardeniae fructus (GF), an evergreen Rubiaceae shrub, is one of the most commonly used Chinese herbs in traditional Chinese medicine (TCM) and has been used for over a thousand years. It is usually prescribed for the treatment of brain aging, vascular aging, bone and joint aging, and other age-related diseases. It has been demonstrated that several effective compounds of GF, such as geniposide, genipin and crocin, have neuroprotective or related activities which are involved in senile disease treatment. These bioactivities include the mitochondrion dysfunction, antioxidative activity, apoptosis regulation and an anti-inflammatory activity, which related to multiple signaling pathways such as the nuclear factor-κB pathway, AMP-activated protein kinase signaling pathway, and the mitogen-activated protein kinase pathway. To lay the ground for fully elucidating the potential mechanisms of GF in treating age-related pathologies, we summarized the available research conducted in the last fifteen years about GF and its effective components, which have been studied in vivo and in vitro

EVALUATION ON RESPONSIBILITY OF QUALITY OF LIFE SCALE IN PATIENTS WITH VIRAL MYOCARDITIS

Objectives To evaluate the responsibility of Quality of Life Scale in Patients with Viral Myocarditis (QOL-VMC Scale). Methods Fifty patients who were diagnosed viral myocarditis filled in the QOL-VMC Scale before and after treatment. The responsibility of QOL-VMC Scale was evaluated from both the change of QOL-VMC Scale score and the effect size. Results After treatment the score of the physiological, psychological and social dimensions and the total score of the scale were all higher than before treatment, and the differences were significant (p<0.01). The effect size of the physiological dimension, social dimension and total scale were between 0.52 and 0.65, while the effect size of the psychological dimension was 0.37. Conclusions QOL-VMC Scale is proved with good responsibility, so it can be used to evaluate the therapeutic effect of viral myocarditis.

RESEARCH ON RELIABILITY AND VALIDITY OF QUALITY OF LIFE SCALE IN PATIENTS WITH VIRAL MYOCARDITIS

Objectives To evaluate the reliability and validity of Quality of Life Scale in Patients with Viral Myocarditis (QOL-VMC Scale) after item selection. Methods 100 patients who were diagnosed viral myocarditis and 100 healthy volunteers filled in the QOL-VMC Scale. Methods such as t-test, correlation analysis and multivariant stepwise regression analysis were applied to evaluate the reliability and validity. Results The evaluation showed that the scale had good test-retest reliability, split-half reliability, consistency reliability, content validity and discriminant validity. The overall construct validity basically matched the initial scale idea of designers. Conclusions The QOL-VMC Scale is proved with good reliability and validity, so it can be used as the supplement of clinical indexes to evaluate the therapeutic effect of viral myocarditis.

Role of Platelet-Monocyte Aggregation in the Onset of Acute Cardiovascular and Cerebrovascular Diseases

Abstract Atherosclerosis is the main pathological basis of cardiovascular and cerebrovascular diseases. Adhesion and aggregation of platelet and monocyte play an important role in patients with acute cardiovascular and cerebrovascular diseases. This article reviews the molecular mechanism of aggregation formation, mechanism of inducing plaque rupture, pathogenesis of impacting acute cardiovascular and cerebrovascular disease occurrence, targets of Chinese medicine and western medicine, corresponding monoclonal antibodies and gene knockout, etc. Problems that existed in the current study are also analyzed to arouse the attention of fellow researchers.