Zhanwei Cui

Mannich type reactions of chlorophosphites, phosphoramides and aldehydes (ketones) under solvent-free and catalyst-free conditions—synthesis of N-phosphoramino α-aminophosphonates

A convenient and rapid method was developed for the synthesis of various N-phosphoramino α-aminoalkylphosphonates through Mannich type reactions under catalyst- and solvent-free conditions with excellent yields.

The diastereoselective synthesis of methyl 5-deoxy-5-(dialkylphosphono)-5-(dialkylphosphorylamido)-2,3-O-isopropylidene-β-d-ribofuranosides

A convenient method has been developed for the diastereoselective synthesis of methyl 5-deoxy-5-(dialkylphosphono)-5-(dialkylphosphorylamido)-2,3-O-isopropylidene-beta-d-ribofuranosides under mild conditions, namely the reaction of a dialkyl phosphoramidate with a dialkyl phosphite and methyl 2,3-O-isopropylidene-beta-D-ribo-pentodialdo-1,4-furanoside in acetyl chloride in a one-pot procedure.

Synthesis of Diphenyl α-(O-Phenyl Bis(2-Chloroethyl) amidophosphorylamino)-Phosphonates

A study on Mannich type reaction synthesis of Diphenyl α-[phenyl N,N-bis(2-chloroethyl) phosphorylamino]methylphosphonates has been carried out. Their geometric stereoisomers were isolated and characterized. The reaction was catalyzed by acetyl chloride and good to excellent yields were obtained under these reaction conditions.

Synthesis of N-Protected o-Hydroxyl-phenyl—α-Aminophosphonic Monoester

A series of N-protected O-hydroxylphenyl α-aminophosphonic monoesters were synthesized via three-component Mannich-type reactions of phosphoramides, aldehydes (ketones) and 2-chlorobenzo [1,3,2] dioxaphospholes under solvent free and catalyst-free conditions, followed by hydrolysis. It is an efficient and green method to the synthesis of N-phosphoramino O-hydroxyphenyl 1-aminoalkylphosphonic monoesters with high yields.