Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Zhiguo Sun is active.

Publication


Featured researches published by Zhiguo Sun.


Biomaterials | 2014

Biodegradable self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer

Jingbin Huang; He Zhang; Yuan Yu; Yan Chen; Dong Wang; Guoqing Zhang; Guichen Zhou; Junjie Liu; Zhiguo Sun; Duxin Sun; Ying Lu; Yanqiang Zhong

To develop biodegradable docetaxel-loaded self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers were successfully synthesized. These copolymers could form nanoparticles with small size (<200 nm), an acceptable CMC (~7.9 mg/L), typical core/shell structure and superior stability in one week. DTX-loaded PLGA(502H)-b-HA(5.6k) nanoparticles (DTX/SANPs) showed a biphasic release pattern within 120 h, and exhibited enhanced cytotoxicity toward CD44-overexpressing MDA-MB-231 cells. Cellular uptake study indicated that PLGA(502H)-b-HA(5.6k) nanoparticles (SANPs) were taken up in MDA-MB-231 cells by CD44-mediated endocytosis. Pharmacokinetics study revealed DTX/SANPs could prolong the circulation of DTX in the blood. In vivo studies demonstrated that SANPs exhibited enhanced tumor targeting and antitumor activity with lower systemic toxicity. In conclusion, DTX/SANPs have great potential for targeted chemotherapy for CD44-overexpressing breast cancer.


Biomaterials | 2013

The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel

Dong Wang; Jingbin Huang; Xinxia Wang; Yuan Yu; He Zhang; Yan Chen; Junjie Liu; Zhiguo Sun; Hao Zou; Duxin Sun; Guichen Zhou; Guoqing Zhang; Ying Lu; Yanqiang Zhong

Breast cancer stem cells (BCSCs), which can fully recapitulate the tumor origin and are often resistant to chemotherapy and radiotherapy, are currently considered as a major obstacle for breast cancer treatment. To achieve the goal of both targeting BCSCs and bulk breast cancer cells, we developed 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticles (MSN)-supported lipid bilayers (HA-MSS) and docetaxel-loaded MSS. The results showed that the size of all the nanoparticles was smaller than 200 nm. BCSCs were enriched from MCF-7 cells by a sphere formation method and identified with the CD44(+)/CD24(-) phenotype. Quantitative and qualitative analysis demonstrated that HA promotes the uptake of HA-MSS in CD44-overexpressing MCF-7 mammospheres, revealing the mechanism of receptor-mediated endocytosis. DTX or DTX-loaded MSS showed much enhanced cytotoxicity against MCF-7 cells compared with MCF-7 mammospheres, whereas 8-HQ or 8-HQ-loaded HA-MSS showed much enhanced cytotoxicity against MCF-7 mammospheres compared with MCF-7 cells. In the MCF-7 xenografts in mice, the combination therapy with DTX-loaded MSS plus 8-HQ-loaded HA-MSS produced the strongest antitumor efficacy, with little systemic toxicity (reflecting by loss of body weight) in mice. Thus, this combination therapy may provide a potential strategy to improve the therapy of breast cancer by eradication of breast cancer cells together with BCSCs.


Nanomedicine: Nanotechnology, Biology and Medicine | 2015

iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells

Xiaoli Mao; Junjie Liu; Zhirong Gong; He Zhang; Ying Lu; Hao Zou; Yuan Yu; Yan Chen; Zhiguo Sun; Wei Li; Bohua Li; Jie Gao; Yanqiang Zhong

AIMS To develop novel iRGD (internalizing Arg-Gly-Asp peptide)-conjugated DSPE-PEG2000 nanomicelles (M-SAL-iRGD) for delivery of salinomycin to both liver cancer cells and cancer stem cells (CSCs). MATERIALS & METHODS The characterization, antitumor activity and mechanism of action of M-SAL-iRGD were evaluated. RESULTS & CONCLUSION M-SAL-iRGD possessed a small size of around 10 nm, and drug encapsulation efficacy higher than 90%. M-SAL-iRGD showed significantly increased cytotoxic effect toward both nontargeted M-SAL (salinomycin-loaded DSPE-PEG2000 nanomicelles) and salinomycin in both liver cancer cells and CSCs. The tissue distribution and antitumor assays in mice bearing liver cancer xenograft confirmed the superior penetration tumor efficacy and antitumor activity of M-SAL-iRGD. M-SAL-iRGD represent a potential effective nanomedicine against liver cancer.


Peptides | 2013

Exenatide-loaded PLGA microspheres with improved glycemic control: In vitro bioactivity and in vivo pharmacokinetic profiles after subcutaneous administration to SD rats

Jiming Xuan; Ya-ling Lin; Jingbin Huang; Fei Yuan; Xiaoqing Li; Ying Lu; He Zhang; Junjie Liu; Zhiguo Sun; Hao Zou; Yan Chen; Jing Gao; Yanqiang Zhong

A subcutaneous exenatide delivery system was developed and characterized in vitro and in vivo. The results clearly showed that the exenatide loaded PLGA microspheres prepared by using a non-aqueous processing medium had low burst release and high drug encapsulation efficiency. Exenatide loaded in the microspheres preserved its bioactivity. The pharmacokinetics parameters were determined after subcutaneous administration of microspheres to SD rats. The plasma concentration of the single dose of the sustained-release microspheres attained C(max) of 108.19±14.92 ng/ml at t(max) of 1.33±0.58 h and the t(½) was 120.65±44.18 h. There was a linear correlation between the in vitro and in vivo release behavior (R²=0.888). Exenatide loaded microspheres may prove to have great potential for clinical use.


Nanomedicine: Nanotechnology, Biology and Medicine | 2016

Codelivery of salinomycin and chloroquine by liposomes enables synergistic antitumor activity in vitro.

Fangyuan Xie; Siyue Zhang; Junjie Liu; Zhirong Gong; Kaixuan Yang; He Zhang; Ying Lu; Hao Zou; Yuan Yu; Yan Chen; Zhiguo Sun; Xinxia Wang; Hai Zhang; Guoqing Zhang; Wei Li; Bohua Li; Jie Gao; Yanqiang Zhong

AIM To improve the suboptimal therapeutic efficacy of salinomycin (SAL) toward liver cancer cells using chloroquine (CQ) combination by the liposomes co-delivering SAL and CQ (SCNL). MATERIALS & METHODS The synergy of these two drugs was evaluated in liver cancer cells (HepG2) and liver cancer stem cells (LCSCs) by median-effect analysis. SCNL with optimized ratio were developed. The cytotoxic effect and basal autophagy flux (measure of autophagic degradation activity) of various formulations were evaluated. RESULTS & CONCLUSION CQ could significantly increase the cytotoxic effect of SAL in HepG2 cells, but not in HepG2-LCSCs, due to the greater basal autophagy flux in HepG2 cells. This combination therapy is promising for liver cancer treatment by eradicating liver cancer cells and LCSCs.


International Journal of Nanomedicine | 2016

Promotion of the transdermal delivery of protein drugs by N -trimethyl chitosan nanoparticles combined with polypropylene electret

Ye Tu; Xinxia Wang; Ying Lu; He Zhang; Yuan Yu; Yan Chen; Junjie Liu; Zhiguo Sun; Lili Cui; Jing Gao; Yanqiang Zhong

We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs of low molecular weight. The aim of this study was to investigate whether electret could enhance the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles (TMC NPs) prepared by an ionic gelation method. A series of experiments were performed, including in vitro skin permeation assays and anti-inflammatory effects, to evaluate the transdermal delivery of protein drugs by TMC NPs in the presence of electret. The results showed that in the presence of electret, the transdermal delivery of protein drugs in TMC NPs was significantly enhanced, as demonstrated by in vitro permeation studies and confocal laser scanning microscopy. Notably, superoxide dismutase-loaded TMC NPs combined with electret exhibited the best inhibitory effect on the edema of the mouse ear. TMC NPs combined with electret represent a novel platform for the transdermal delivery of protein drugs.


Nanomedicine: Nanotechnology, Biology and Medicine | 2017

Therapeutic PEG-ceramide nanomicelles synergize with salinomycin to target both liver cancer cells and cancer stem cells

Meiping Wang; Fangyuan Xie; Xikai Wen; Han Chen; Hai Zhang; Junjie Liu; He Zhang; Hao Zou; Yuan Yu; Yan Chen; Zhiguo Sun; Xinxia Wang; Guoqing Zhang; Chuan Yin; Duxin Sun; Jie Gao; Beige Jiang; Yanqiang Zhong; Ying Lu

AIM Salinomycin (SAL)-loaded PEG-ceramide nanomicelles (SCM) were prepared to target both liver cancer cells and cancer stem cells. MATERIALS & METHODS The synergistic ratio of SAL/PEG-ceramide was evaluated to prepare SCM, and the antitumor activity of SCM was examined both in vitro and in vivo. RESULTS SAL/PEG-ceramide molar ratio of 1:4 was chosen as the synergistic ratio, and SCM showed superior cytotoxic effect and increased apoptosis-inducing activity in both liver cancer cells and cancer stem cells. In vivo, SCM showed the best tumor inhibitory effect with a safety profile. CONCLUSION Thus, PEG-ceramide nanomicelles could serve as an effective and safe therapeutic drug carrier to deliver SAL into liver cancer, opening up the avenue of using PEG-ceramide as therapeutic drug carriers.


Journal of Controlled Release | 2008

Preparation and characterization of PE38KDEL-loaded anti-HER2 nanoparticles for targeted cancer therapy☆

Huaiwen Chen; Jie Gao; Ying Lu; Geng Kou; He Zhang; Li Fan; Zhiguo Sun; Yajun Guo; Yanqiang Zhong


Nanomedicine: Nanotechnology, Biology and Medicine | 2016

Codelivery of salinomycin and doxorubicin using nanoliposomes for targeting both liver cancer cells and cancer stem cells.

Zhirong Gong; Dazhong Chen; Fangyuan Xie; Junjie Liu; He Zhang; Hao Zou; Yuan Yu; Yan Chen; Zhiguo Sun; Xinxia Wang; Hai Zhang; Guoqing Zhang; Chuan Yin; Jie Gao; Yanqiang Zhong; Ying Lu


Archive | 2010

Exenatide release microsphere preparation, preparation method and application thereof

Yanqiang Zhong; Jing Gao; Jiming Xuan; He Zhang; Hao Zou; Ying Lu; Zhiguo Sun; Yan Chen; Yuan Yu

Collaboration


Dive into the Zhiguo Sun's collaboration.

Top Co-Authors

Avatar

Yanqiang Zhong

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

He Zhang

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Ying Lu

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Yan Chen

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Hao Zou

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Junjie Liu

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Yuan Yu

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Guoqing Zhang

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Jie Gao

Second Military Medical University

View shared research outputs
Top Co-Authors

Avatar

Jing Gao

Second Military Medical University

View shared research outputs
Researchain Logo
Decentralizing Knowledge