Zhiyong Peng
Southern Medical University
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Publication
Featured researches published by Zhiyong Peng.
Molecular Medicine Reports | 2018
Wenfang Yi; Fuyu Pei; Wen Ding; Mo Yang; Guang Lin; Cheng Zhang; Xuedong Wu; Yuelin He; Xiaoqin Feng; Huanying Liu; Zhiyong Peng; Chunfu Li
The use of chemotherapeutic agents prior to treatment with infusion of cluster of differentiation (CD)19-chimeric antigen receptor (CAR)-T cells is important for the efficacy of clinical therapies against hematological malignancies. However, the effect of chemotherapeutic agents on CD19-CAR-T cells and the associated underlying mechanisms remain unknown. The first aim of the present study was to determine the effect of chemotherapeutic agents on CAR-T cells using the in vitro Cell Counting kit 8 assay. The second aim was to evaluate the abilities of fludarabine (FDR) and mafosfamide (MFA; a metabolite of cyclophosphamide) to induce apoptosis of CD19-CAR-T cells via the use of Annexin V/propidium iodide double staining. In addition, a JC-1 fluorescent probe was used to detect alterations in cell membrane potential, and flow cytometry analysis was used to measure concentrations of caspase-3/7 to identify apoptotic pathways of CD19-CAR-T cells. The data of the present study suggested that FDR and MFA inhibit the activities of CD19-CAR-T cells. Alterations to the mitochondrial membrane potential and an increase in the concentration of caspase-3/7 indicated early apoptosis of FDR- and MFA-treated CD19-CAR-T cells. The present study laid a theoretical foundation for the development of programs for clinical treatment.
British Journal of Haematology | 2017
Jianyun Liao; Goundo Sylla; Yuelin He; Wing Leung; Xiaoting Liu; Jiaqi Chen; Zhiyong Peng; Fuyu Pei; Na Li; Yuqiong Ren; Xiaoqin Feng; Xuedong Wu; Chunfu Li
Keywords: thalasssaemia; killer-cell immunoglobulin-like receptor; haematopoietic stem cell transplantation; human leucocyte antigen; engraftment
Blood | 2016
Chunfu Li; Yuelin He; Xuedong Wu; Xiaoqin Feng; Jianyun Liao; Fuyu Pei; Zhiyong Peng; Huaying Liu; Wing Leung
Blood | 2017
Zhiyong Peng; Xiaoqin Feng; Yuelin He; Yuchen Lin; Jianyun Liao; Xuedong Wu; Jiaqi Chen; Chunfu Li
Blood | 2016
Jianyun Wen; Yuelin He; Libai Chen; Jing Du; Zhiyong Peng; Jianyun Liao; Huaying Liu; Xiaohui Zhou; Chunfu Li; Xuedong Wu
Blood | 2016
Chunfu Li; Yuelin He; Xuedong Wu; Xiaoqin Feng; Jianyun Liao; Zhiyong Peng; Fuyu Pei; Huaying Liu; Wing Leung
Blood | 2014
Yuelin He; Xuedong Wu; Yongsheng Ruan; Zhiyong Peng; Xiaoqin Feng; Jianyun Liao; Huaying Liu; Wenfeng Xu; Na Li; Chunfu Li
Blood | 2014
Zhiyong Peng; Chunfu Li; Yuelin He
Blood | 2014
Fuyu Pei; Qi Li; Wenfeng Xu; Zhiyong Peng; Xuedong Wu; Yuelin He; Xiaoqin Feng; Chunfu Li
Blood | 2014
Chunfu Li; Fuyu Pei; Qi Li; Jianyun Liao; Shengli An; Xuedong Wu; Yuelin He; Xiaoqin Feng; Xiaohui Zhou; Lei Shi; Huaying Liu; Na Li; Wenfeng Xu; Wanxia Tan; Zhiyong Peng; Jiaqi Chen; Yuqiong Ren