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Dive into the research topics where Zhong-Wei Zhang is active.

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Featured researches published by Zhong-Wei Zhang.


Bioorganic & Medicinal Chemistry | 2008

Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates

Xin-Bin Yang; Jie Feng; Ji Zhang; Zhong-Wei Zhang; Hong-Hui Lin; Li-Hong Zhou; Xiao-Qi Yu

A series of the copper (II) complexes 5a-d of estrogen-macrocyclic polyamine conjugates were synthesized and characterized. The interactions of complexes 5a-d with DNA were studied by fluorescence spectroscopy and gel electrophoresis under physiological conditions. The results indicate that the conjugated estrogens have increased the cleavage efficiency of Cu[cyclen](2+) while the conjugates display poor binding affinities. The functional groups of D-ring of estrogens may play a key role in deciding binding and cleavage extent of the complexes to DNA.


European Journal of Medicinal Chemistry | 2009

Self-activating chemical nuclease: ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant.

Kun Li; Li-Hong Zhou; Ji Zhang; Shan-Yong Chen; Zhong-Wei Zhang; Jing-Jing Zhang; Hong-Hui Lin; Xiao-Qi Yu

The interactions of cyclen Cu(II) complexes functionalized by ferrocenyl group with plasmid DNA indicated that these complexes have high cleavage efficiency via an oxidative mechanism in the absence of any reductant or oxidant.


Journal of Enzyme Inhibition and Medicinal Chemistry | 2009

A new Schiff base copper (II) complex derived from estrone and d-glucosamine: Synthesis, characterization and its interaction with DNA

Xin-Bin Yang; Li Wang; Ji Zhang; Zhong-Wei Zhang; Hong-Hui Lin; Li-Hong Zhou; Xiao-Qi Yu

A novel copper (II) complex of Schiff base prepared through condensation between 2-formyl-17-deoxyestrone and d-glucosamine was synthesized and characterized. Fluorescence spectroscopy was conducted to assess their binding ability with CT-DNA. The results showed that the copper (II) complex could bind to DNA with a weak intercalative mode. The interaction between the copper (II) complex and DNA was also investigated by gel electrophoresis. Interestingly, we found that the complex could cleave plasmid DNA (pUC19) to nicked and linear forms through an oxidative mechanism without the use of exogenous agents.


Chemistry & Biodiversity | 2009

Synthesis and DNA-cleavage activities of dinuclear copper(II) complexes of urea-bridged macrocyclic polyamines.

Yang Yue; Jing Li; Ji Zhang; Zhong-Wei Zhang; Hong-Hui Lin; Shan-Yong Chen; Xiao-Qi Yu

Two dinuclear macrocyclic polyamine copper(II) (CuII) complexes, which have two cyclen units linked by urea, were synthesized as DNA‐cleavage agents. The structures of these new dinuclear complexes were identified by HR‐ESI‐MS and IR analyses. The catalytic activities of DNA cleavage of these dinuclear CuII complexes were subsequently studied. The results show that 6a was the better catalyst in the DNA‐cleavage process than 6b. The effects of reaction time and concentration of complexes were also investigated. The results indicate, that the CuII complexes could catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA; Formu2005I) under physiological conditions to produce selectively nicked DNA (Formu2005II; no Formu2005III was produced) with high yields (nearly 100%) in short time in the absence of reductant or oxidant.


Chemistry & Biodiversity | 2009

Cyclen‐Based Side‐Chain Homopolymer Self‐Assembly with Plasmid DNA: Protection of DNA from Enzymatic Degradation

Kun Li; Na Wang; Fan Yang; Zhong-Wei Zhang; Li-Hong Zhou; Shan-Yong Chen; Hong-Hui Lin; Yun-Fei Tian; Xiao-Qi Yu

In this study, a 1,4,7,10-tetraazacyclododecane (cyclen)-based side-chain homopolymer was developed for the first time; this polymer can self-assembly with plasmid DNA to form polyelectrolyte complexes (polyplex), which can protect DNA from enzymatic degradation. Moreover, the polyplex can disassembly and release free DNA when NaCl solution is added to this system. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) are used for imaging of the surface structure of the polyplex, and results indicated that the polyplex structures respond to the polymer concentration. Circular dichroism (CD) spectrum suggested that the DNA configuration in the polyplex was retained.


Chemistry & Biodiversity | 2009

The Effect of an Amino-Acid Bridge on Binding Affinity and Cleavage Efficiency of Pyrenyl-Macrocyclic Polyamine Conjugates toward DNA

Qiao-Sen Lu; Yu Huang; Jing Li; Zhong-Wei Zhang; Hong-Hui Lin; Xiao-Qi Yu

A series of pyrenyl‐macrocyclic polyamines 5a–5c have been prepared and characterized. Their DNA‐cleavage properties were examined under physiological conditions. Without the presence of other additives, the DNA cleavage ability of 5a–5c showed the order of 5c>5a>5b. Absorption and fluorescence experiments showed the binding affinity of 5a–5c to DNA. The interactions of 5a–5c with CT‐DNA indicated that the DNA binding ability followed an order according to their cleavage efficiency. All the results indicated that the structures of amino‐acid bridge in the ligands may affect the DNA binding and cleavage ability. The cleavage‐mechanism studies indicated that singlet oxygen and superoxide free radicals were involved in the catalytic DNA cleavage process.


Bioorganic & Medicinal Chemistry | 2008

DNA cleavage by novel copper (II) complex and the role of β-cyclodextrin in promoting cleavage

Yu Huang; Qiao-Sen Lu; Ji Zhang; Zhong-Wei Zhang; Yu Zhang; Shan-Yong Chen; Kun Li; Xin-Yu Tan; Hong-Hui Lin; Xiao-Qi Yu


Journal of Applied Polymer Science | 2009

Immobilization cyclen copper (II) on merrifield resin: Efficient oxidative cleavage of plasmid DNA

Kun Li; Ji Zhang; Zhong-Wei Zhang; Yong-Zhe Xiang; Hong-Hui Lin; Xiao-Qi Yu


Science China-chemistry | 2009

Novel cyclen-based linear polymer as a high-affinity binding material for DNA condensation

Yong-Zhe Xiang; Na Wang; Ji Zhang; Kun Li; Zhong-Wei Zhang; Hong-Hui Lin; Xiao-Qi Yu


Transition Metal Chemistry | 2008

Arm effects of mononuclear armed cyclen copper complexes on DNA cleavage

Jing Li; Yang Yue; Ji Zhang; Qiao-Sen Lu; Kun Li; Yu Huang; Zhong-Wei Zhang; Hong-Hui Lin; Na Wang; Xiao-Qi Yu

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