Zhongjiao Ren

THE KNOEVENAGEL CONDENSATION REACTION OF AROMATIC ALDEHYDES WITH MALONONITRILE BY GRINDING IN THE ABSENCE OF SOLVENTS AND CATALYSTS

ABSTRACT An improved Knoevenagel condensation reaction of aldehydes and malononitrile can be achieved by grinding at room temperature in the absence of solvents and catalysts. This process is simple, efficient, economical, and environmentally benign. Compared to reactions carried out by microwave irradiation, this procedure is completely free from organic solvents during both the reaction and separation of the product.

THE KNOEVENAGEL CONDENSATION OF AROMATIC ALDEHYDES WITH MALONONITRILE OR ETHYL CYANOACETATE IN THE PRESENCE OF CTMAB IN WATER

A new route of Knoevenagel condensation of aldehydes with malononitrile or ethyl cyanoacetate in the presence of CTMAB in water is described. CTMAB is the most effective catalyst to increase yield among CTMAB, BTEAC and TBAI.

KNOEVENAGEL CONDENSATION OF ALDEHYDES WITH CYCLIC ACTIVE METHYLENE COMPOUNDS IN WATER

ABSTRACT A new route of Knoevenagel condensation of aromatic aldehydes with Meldrums acid, barbituric acid and dimedone in the presence of cetyltrimethyl ammonium bromide at room temperature in water is described.

Solvent‐Free, One‐Pot Synthesis of Pyrano[2,3‐c]pyrazole Derivatives in the Presence of KF·2H2O by Grinding

Abstract A solvent‐free, one‐pot process for the preparation of 4H‐pyrans in the presence of KF · 2H2O by grinding was achieved. Its advantages are easy workup, mild reaction conditions, high yields, and environmental friendliness.

Solvent‐Free Synthesis of Ethyl α‐Cyanocinnamate in the Presence of CaO

Abstract Ethyl α‐cyanocinnamate can be prepared by grinding in the presence of CaO at room temperature. This method is simple, efficient, economical, and environmentally benign.

Solvent-free stereoselective synthesis of cis-1-carbomethoxy-2-aryl-3,3-dicyanocyclopropanes by grinding

Abstract The novel route of high stereoselective synthesis of cis‐1‐carbomethoxy‐2‐aryl‐3,3‐dicyanocyclopropanes by grinding is described. This process is simple, efficient, and environmentally benign.

Solvent‐Free Synthesis of 2‐Arylideneindan‐1,3‐diones in the Presence of Magnesium Oxide or Silica Gel Under Grinding

Abstract The solvent‐free synthesis of 2‐arylideneindan‐1,3‐diones can be achieved in the presence of MgO or silica gel under grinding. This process is simple, efficient, and environmentally benign.

Stereoselective Synthesis of cis‐1‐Aryl‐2‐benzoyl‐3,3‐dicyanocyclopropanes in the Presence of KF·2H2O

Abstract KF · 2H2O was found to be a highly efficient base for synthesis of cis‐1,2‐cyclopropanes with arsonium salt and olefins. The advantages of the process are mild reaction condition, easy workup, excellent yields, and high stereoselectivity.

Solvent-Free One-Pot Synthesis of Spiro[indoline-3,4′(1H′)-pyrano[2,3-c]pyrazol]-2-one Derivatives by Grinding

Abstract The solvent-free one pot synthesis of spiropyranyl-oxindole in the presence of NaHCO3 under grinding has been achieved. This process is simple, fast, efficient and environmentally benign.

Stereoselective synthesis of cis-1-aryl-2-benzoyl-3,3-dicyanocyclopropanes in water

Abstract The highly stereoselective preparation of cis‐1‐aryl‐2‐benzoyl‐3,3‐dicyanocyclopropanes with arsonium salt and olefin in water is described. It is simple, efficient, and environmentally benign.