Zicheng Wang

An Improved Method of DNA Information Encryption

A scheme utilizing DNA technology for the purposes of DNA cryptography has been developed. To enhance the security of DNA cryptosystem, we used DNA digital encoding, complementary rules and biotechnological methods in this scheme. The experimental result showed that the scheme is feasible and the security analysis indicated that the scheme has a strong confidentiality.

A DNA Code Converter Model for Decimal Numbers Displaying

DNA has recently emerged as a powerful and novel material for creating nano-scale electronic architectures and devices. Based on DNA strand displacement (DSD) reactions, sophisticated multilayered DNA molecular circuits have been rationally designed to perform different functions. In this paper, a code converter circuit, which can be used to compute logic states of a seven-segment digital tube, is designed for decimal numbers displaying. In addition, the logic circuit is further translated into its correspondingly dual-rail circuit and seesaw cascade circuit. The simulation results show that our logic circuits are effective and feasible for decimal numbers displaying.

Multi-digit Logic Operation Using DNA Strand Displacement

DNA strand displacement which is an approach of dynamic nanotechnology has been widely used in constructing of molecular logic circuit, molecular automata and nanomedicine and so on. DNA strand displacement is enormous capable of implementation of logical calculation which plays a critical role in the acquirement of bio-computer. In our paper, the multi-digit full adder which is based on the reaction of DNA strand displacement is designed and has been verified by simulation of DSD (DNA strand displacement). The accuracy of simulation result further confirmed DNA strand displacement is a valid method for the research of logical bio-chemical circuit.

Comparator Logic Circuits Based on DNA Strand Displacement by DNA Hairpin

DNA computing is a hot research topic in recent years, molecular logic gate is an important foundation of DNA computer architecture and implementation. Local hairpin DNA chain substitution reaction can increase the reliability of molecular logic gates, Make the reaction more efficient and more thoroughly. In this paper, using local hairpin DNA strand displacement, the comparator circuit is coded and simulated base on the double logic circuit. The simulation results further confirmed the feasibility and effectiveness of the DNA strand displacement reaction in the study of biochemical logic circuits, The comparator circuit can be used for biological computer and building large-scale molecular logic circuits in the future.

A Universal Platform for Building DNA Logic Circuits

DNA strand displacement has great potential for use in logic circuits. In the paper, the two DNA-based logic circuits that behave as half-subtract and half-adder were implemented relying on strand displacement and fluorescence labeling technique. The half-adder and half-subtract were achieved by simply modifying the sequences of the input strands, while retaining the same DNA logical structure as a universal platform. By taking advantage of the branch migration mechanism, separation and combination of fluorescent group were controlled, two series of fluorescence signals were defined as the output signal. We simulated within the Visual DSD design tool which analyzes their performance and proves the correctness of the circuits. The system reported herein is rather concise compared to other molecular logic gate systems.

The Design of Voting Device Based on DNA Strand Displacement Reaction

DNA strand displacement reaction (DSDR) has become a significant issue in DNA computing in recent years. The voting device has been playing an important role in some occasions. A 4-people voting device was designed based on DSDR in this paper. The process of DSDR is programmed and simulated in visual DSD. The simulated results demonstrate that the molecular model of voting device is feasible and reliable, which has wide prospects in complicated molecular logic circuits study.

The Design of Digital Circuit Based on DNA Strand Displacement Reaction

Because of its outstanding advantages, DNA strand displacement (DSD) reaction has been widely used for signals processing and molecular logic circuit constructing. Two digital logic circuits are constructed in this paper. One is the encoder circuit with four inputs and two outputs, and the other is the decoder circuit with two inputs and four outputs. Finally, the circuits can be programmed and simulated with the software Visual DSD. The simulated results based on DSD show that the molecular circuits constructed in this paper is reliable and effective, which has wide prospects in logical circuits and nano electronics study.

A 3D DNA Self-assembly Model and Algorithm for Minimum Spanning Tree Problem

The minimum spanning tree (MST) problem has been widely studied for its wide applicationsin recent years. Because of its outstanding advantages, DNA self-assembly computing has been used to solve MST problem. A new paradigm, called a three dimensional (3D) DNA self-assembly model, is proposed for this type of problem in this paper. The results show that it is efficient in solving MST problem and the algorithm has a high-efficiency.