A Fillmer

Constrained image-based B0 shimming accounting for “local minimum traps” in the optimization and field inhomogeneities outside the region of interest

To improve B0 shimming for applications in high‐ and ultrahigh‐field magnetic resonance imaging and magnetic resonance spectroscopy.

Reduction of voxel bleeding in highly accelerated parallel 1H MRSI by direct control of the spatial response function

To substantially improve spatial localization in magnetic resonance spectroscopic imaging (MRSI) accelerated by parallel imaging. This is important in order to make MRSI more reliable as a tool for clinical applications.

Fast iterative pre-emphasis calibration method enabling third-order dynamic shim updated fMRI

To calibrate a pre‐emphasis to sufficiently compensate eddy currents for application of dynamic shim updating to fMRI without extension of scan times.

Mechanisms of SNR and line shape improvement by B0 correction in overdiscrete MRSI reconstruction

Inhomogeneities of the main magnetic field cause line broadening and location‐dependent frequency shifts in brain MRSI. These are often visible despite advanced B0 shimming. The purpose of this work is to propose an advanced B0 correction method that can easily be applied during postprocessing.

A Comparison of Optimization Algorithms for Localized in-vivo B0 Shimming

To compare several different optimization algorithms currently used for localized in vivo B0 shimming, and to introduce a novel, fast, and robust constrained regularized algorithm (ConsTru) for this purpose.

Non-Water-Suppressed 1H MR Spectroscopy with Orientational Prior Knowledge Shows Potential for Separating Intra- and Extramyocellular Lipid Signals in Human Myocardium

Conditions such as type II diabetes are linked with elevated lipid levels in the heart, and significantly increased risk of heart failure; however, metabolic processes underlying the development of cardiac disease in type II diabetes are not fully understood. Here we present a non-invasive method for in vivo investigation of cardiac lipid metabolism: namely, IVS-McPRESS. This technique uses metabolite-cycled, non-water suppressed 1H cardiac magnetic resonance spectroscopy with prospective and retrospective motion correction. High-quality IVS-McPRESS data acquired from healthy volunteers allowed us to investigate the frequency shift of extramyocellular lipid signals, which depends on the myocardial fibre orientation. Assuming consistent voxel positioning relative to myofibres, the myofibre angle with the magnetic field was derived from the voxel orientation. For separation and individual analysis of intra- and extramyocellular lipid signals, the angle myocardial fibres in the spectroscopy voxel take with the magnetic field should be within ±24.5°. Metabolite and lipid concentrations were analysed with respect to BMI. Significant correlations between BMI and unsaturated fatty acids in intramyocellular lipids, and methylene groups in extramyocellular lipids were found. The proposed IVS-McPRESS technique enables non-invasive investigation of cardiac lipid metabolism and may thus be a useful tool to study healthy and pathological conditions.

Conditions for separation and individual quantification of IMCL and EMCL signals in 1H cardiac MRS

Magnetic Resonance Elastography (MRE): non-invasive MR method quantifying mechanical properties of tissues by imaging the propagation of a shear wave inside the investigated tissue, using a specific MRI sequence.Tissue motion is encoded in phase images thanks to a Motion- Encoding Gradient (MEG) synchronized to an external mechanical excitation. Context: some studies implemented innovative sequences for MRE, but, to our knowledge, none have so far simulated these sequences before experiments. Aim of the study: simulation of a MRE experiment, with a gradient-echo sequence and a dynamical phantom, using the software ODIN.