A. G. Mazhuga

Formation of CuI(CH3CN)4ClO4 in the reactions of copper(II) perchlorate with acetonitrile in the presence of sulfur-containing organic compounds

Cu(ClO4)2·6H2O was shown to react with 2,2′-[propane-1,3-diylbis(thio-2-phenylnemethylidene]-bis(3-pyridylamine) (I) or (5Z)-2-ethoxycarbonylmethyl-(2-pyridylmethylidene)-3,5-dihydro-4H-imidazol-4-one (II) in the presence of CH3CN with the reduction of copper(II) to copper(I) and the formation of the tetrahedral complex CuI(CH3CN)4ClO4 (III). In the course of the reaction the organic ligands I and II were oxidized to the corresponding sulfoxides.

Synthesis of (5Z,5´Z)-3,3´-(alkane-α,ω-diyl)bis[5-(2-pyridylmethylidene)-2-methylthio-3,5-dihydro-4H-imidazol-4-ones] and their coordination compounds with copper(ii)

A synthesis of copper(ii) coordination compounds based on the new tetradentate organic ligands from the series of (5Z,5´Z)-3,3´-(alkane-α,ω-diyl)bis[5-(2-pyridylmethylidene)-2-thio-3,5-dihydro-4H-imidazol-4-ones] was suggested. Biological activity of the copper(ii) coordination compounds was studied, their ability to inhibit telomerase activity was shown.

Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing

We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA–) and LNCaP (PSMA+) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.

Synthesis and optimization of methods for the production of magnetite nanoparticles with different sizes and morphology for biological application

Herein we report on the synthesis, optimization of the synthetic procedure, functionalization, and characterization of cubic and spherical superparamagnetic magnetite nanoparticles. Spherical nanoparticles (16 ± 2 nm) were synthesized using oleylamine and oleic acid, and cubic (20 ± 2, 5 ± 0.5 nm) nanoparticles were synthesized with oleic acid and small amounts of oleylamine. Covalent modification of the nanoparticles was carried out using heterobifunctional PEG with aminopropyltriethoxysilane and N-hydroxysuccinimide ester moieties. This modification makes both water emulsion stability and further modification of the nanoparticles with cytotoxic drugs possible.

Synthesis of gold nanoparticles modified by bis[13-(pyridine-4-yl)tridecyl] disulfide and investigation of their interaction with Cu(II) and Co(II)

Gold nanoparticles that have an average size of 2.2 nm and are modified bó bis[13-(pyridine-4-yl)tridecyl]disulfide have been synthesized, and their aggregation upon interaction with Cu(ClO4) · 6H2O and Co(ClO4) · 6H2O has been investigated. new method to obtain gold nanoparticle ensembles of different shapes and aggregations continues on the basis of the coordination interaction of ligands adsorbed on the surface of gold nanoparticles with a transition metal ions.

Copper-containing enzymes: Site types and low-molecular-weight model compounds

A structured description is suggested for the existing types of copper-containing sites in copper proteins. The most important specific features of mono-, di-, tri-, and tetranuclear sites are reported, and the structural geometry of each site is considered. The functional features and catalytic reactions characteristics of each type of site are discussed. Examples of copper-containing enzyme mimics are considered, and the importance of their synthesis and use is demonstrated.

Сore–shell magnetite–gold nanoparticles: Preparing and functionalization by chymotrypsin

In this work we present the results of the synthesis of magnetite–gold nanoparticles with a core–shell structure. The preparation is carried out in several stages: synthesis of the core, coating with a gold shell, purification of magnetite–gold particles from an uncoated magnetite, and functionalization of the surface with sulfur-containing ligands. The conditions needed for the functionalization of nanoparticles with lipoic acid and mercapto-methoxy polyethylene glycol are indicated in detail, making it possible to determine the optimal conditions needed to achieve an efficient purification and a maximum concentration of the particles in a solution required for biological tests. The possibility of remotely controlling the chymotrypsin properties using an alternating magnetic field has been demonstrated by the example of magnetite–gold nanoparticles. The magnetite–gold nanoparticles which we have obtained are promising for future biomedical applications.

Synthesis and characterization of PEG-silane functionalized iron oxide(II, III) nanoparticles for biomedical application

In this paper we report the synthesis, functionalization, and characterization of ferromagnetic iron oxide (II, III) nanoparticles with different shapes and sizes. Using a number of chemical methods, magnetite nanoparticles having a spherical shape and size of 9 ± 2 nm (coprecipitation), 22 ± 4 nm and 50 ± 6 nm (redox reaction), and 40 ± 5 nm cubes were synthesized. Special attention in this paper is devoted to the covalent modification of magnetite nanoparticles by polymers such as silane-polyethylene glycol (Peg-silane). The main advantage of magnetic nanoparticles modified by polymer is low toxicity, colloidal stability of the prepared magnetite nanoparticles, and the possibility for post functionalization. We determined coercivity and saturated magnetism. Also, the relaxivity T2 was measured by magnetic resonance imaging (MRI). Prepared nanoparticles are of great interest and potential for use in biomedical imaging.

New nanohybrid material based on gold nanoparticles and 1,4-bis(terpyridine-4′-yl)benzene

A facile and convenient method is offered for the synthesis of composite material consisting of 1,4-bis(terpyridine-4′-yl)benzene microcrystals and gold nanoparticles with an average size of ∼15 nm adsorbed on their surfaces. The nanohybrid material is obtained by the deposition of presynthesized nanoparticles on the surface of the organic compound.

Polyolefin ketones adhesive characteristics in model systems polymer-liquid

A contact angle test was applied to determine of energy characteristics of the surfaces of polyolefin ketones at various interfacial boundaries and the work of adhesion of polyolefin ketones was calculated in relation to model liquids of various polarities. A new approach was proposed to optimize the selection of polymers for composite materials. It was demonstrated that the contact angle test is a promising express method of forecasting possible branches of applications for polymer materials.