Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where A. Muniz is active.

Publication


Featured researches published by A. Muniz.


Journal of Ophthalmology | 2014

The Role of Microglia in Diabetic Retinopathy

Jeffery G. Grigsby; Sandra M. Cardona; Cindy E. Pouw; A. Muniz; Andrew S. Mendiola; Andrew Tsin; Donald M. Allen; Astrid E. Cardona

There is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy. There is also evidence that molecules produced as a result of hyperglycemia can activate microglia. However the exact contribution of microglia, the resident immune cells of the central nervous system, to retinal tissue damage during diabetes remains unclear. Current data suggest that dysregulated microglial responses are linked to their deleterious effects in several neurological diseases associated with chronic inflammation. As inflammatory cytokines and hyperglycemia disseminate through the diabetic retina, microglia can change to an activated state, increase in number, translocate through the retina, and themselves become the producers of inflammatory and apoptotic molecules or alternatively exert anti-inflammatory effects. In addition, microglial genetic variations may account for some of the individual differences commonly seen in patients susceptibility to diabetic retinopathy.


Journal of Visualized Experiments | 2015

Deriving retinal pigment epithelium (RPE) from induced pluripotent stem (iPS) cells by different sizes of embryoid bodies.

A. Muniz; Kaini R. Ramesh; Whitney Greene; Jae-Hyek Choi; Heuy-Ching Wang

Pluripotent stem cells possess the ability to proliferate indefinitely and to differentiate into almost any cell type. Additionally, the development of techniques to reprogram somatic cells into induced pluripotent stem (iPS) cells has generated interest and excitement towards the possibility of customized personal regenerative medicine. However, the efficiency of stem cell differentiation towards a desired lineage remains low. The purpose of this study is to describe a protocol to derive retinal pigment epithelium (RPE) from iPS cells (iPS-RPE) by applying a tissue engineering approach to generate homogenous populations of embryoid bodies (EBs), a common intermediate during in vitro differentiation. The protocol applies the formation of specific size of EBs using microwell plate technology. The methods for identifying protein and gene markers of RPE by immunocytochemistry and reverse-transcription polymerase chain reaction (RT-PCR) are also explained. Finally, the efficiency of differentiation in different sizes of EBs monitored by fluorescence-activated cell sorting (FACS) analysis of RPE markers is described. These techniques will facilitate the differentiation of iPS cells into RPE for future applications.


Biochemistry | 2009

Evidence for Two Retinoid Cycles in the Cone-Dominated Chicken Eye

A. Muniz; Brandi S. Betts; Arnoldo R. Trevino; Kalyan Buddavarapu; Ricardo Roman; Jian Xing Ma; Andrew Tsin


Biochemistry | 2006

11-cis-Acyl-CoA:retinol O-acyltransferase activity in the primary culture of chicken Muller cells.

A. Muniz; Elia T. Villazana-Espinoza; Bridget Thackeray; Andrew T.C. Tsin


Investigative Ophthalmology & Visual Science | 2014

Retinoid uptake, processing, and secretion in human iPS-RPE support the visual cycle.

A. Muniz; Whitney Greene; Mark L. Plamper; Jae Hyek Choi; Anthony J. Johnson; Andrew Tsin; Heuy-Ching Hetty Wang


Investigative Ophthalmology & Visual Science | 2006

Specificity of ARAT Activity for 11–cis Retinol in Primary Chicken Muller Cells

A. Muniz; E.T. Villazana–Espinoza; B.Y. Thackeray; Andrew Tsin


Investigative Ophthalmology & Visual Science | 2009

High Concentration of 11-cis Retinyl Esters in the Cone Outer Segments of the Chicken Retina

B.Y. Thackeray; Brandi S. Betts; Arnoldo R. Trevino; A. Muniz; Andrew Tsin


Investigative Ophthalmology & Visual Science | 2007

Activity of Retinol Isomerase, Ester Synthase and Retinol Dehydrogenase in the Isolated Chicken Retina

Elia T. Villazana-Espinoza; Andrea L. Hatch; A. Muniz; Andrew Tsin


Investigative Ophthalmology & Visual Science | 2007

Isomerization of All-Trans Retinol to 11-cis Retinol in the Cone Dominant Mammalian Retina

A. Muniz; A. Mukherjee; Andrea L. Hatch; Elia T. Villazana-Espinoza; Donald M. Allen; Andrew Tsin


Investigative Ophthalmology & Visual Science | 2007

Effects of Estrogen on Rhesus Monkey Retinal Capillary Endothelial Cell Proliferation

Jeffery G. Grigsby; Andrew Tsin; A. Muniz; A. Murkerjee; Donald M. Allen

Collaboration


Dive into the A. Muniz's collaboration.

Top Co-Authors

Avatar

Andrew Tsin

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

Donald M. Allen

University of Texas of the Permian Basin

View shared research outputs
Top Co-Authors

Avatar

Elia T. Villazana-Espinoza

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

A. Mukherjee

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

Andrea L. Hatch

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

Arnoldo R. Trevino

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

Brandi S. Betts

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

E.T. Villazana–Espinoza

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

Jeffery G. Grigsby

University of Texas at San Antonio

View shared research outputs
Top Co-Authors

Avatar

A. Artis

University of Texas at San Antonio

View shared research outputs
Researchain Logo
Decentralizing Knowledge