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Acta Ophthalmologica | 2013

Secondary glaucoma in familial amyloid polyneuropathy

A Rousseau; E Barreau; G. Kaswin; C Cauquil; M Theaudin; D Adams; Marc Labetoulle

Purpose To describe the clinical features of secondary glaucoma associated with transthyretin (TTR)-related Familial Amyloid Polyneuropathy (FAP). n n n nMethods In this retrospective monocentric study, 5 patients with FAP associated secondary glaucoma were seen at the ophtalmologic consultation of the french national center for FAP between 2011 and 2012. The mutation of the amyloidogenic TTR variants was analysed for all patients. All patients had a complete ophthalmic examination including BCVA, IOP, slit lamp and optic disc photographs, gonioscopy, pachymetry, automated perimetry, and OCT-RNFL. Glaucomatous optic neuropathy was diagnosed based on the presence of visual field abnormalities, neuroretinal rim thining, excavation or RNFL defects. Medical and surgical treatments were analysed for all patients. n n n nResults All cases had bilateral involvement except 2 monophtalmic patients. All patients were of portuguese origin and carriers of the Val30Met mutation. There were 4 women and 1 man with a mean age of 58.8±7.7 years. Mean BCVA was 0,83±0.9 LogMAR. Three eyes had a BCVA below 20/400. Mean IOP was 26.6±6.6 mmHg. Mean deviation was -17.6±11.2dB. Fringed pupil and anterior chamber amyloid deposition were noted in all affected eyes. Three patients had concomitent vitreous involvement. Patients were treated with 1.2±1.5 ocular hypotensive drugs. Four eyes had been treated with at least 1 filtrating surgery. n n n nConclusion FAP-associated secondary glaucoma is a very severe disease, associated with amyloid deposits in the anterior chamber and characteristic pupil deformation. Systematic and comprehensive eye examination should be performed in all patients affected with FAP in order to improve early detection of glaucoma.


Acta Ophthalmologica | 2014

A prospective study of ocular manifestations in transthyretin-related familial amyloid polyneuropathy

J Meney; E Barreau; Z Mincheva; C Cauquil; Marc Labetoulle; D Adams; A Rousseau


Acta Ophthalmologica | 2012

HSV1-specific meganuclease may reduce ocular infection in a mouse model of herpes keratitis

Marc Labetoulle; Eric E. Gabison; A Rousseau; Nicolas Huot; B Chapellier; M Gailledrat; Ayla Ergani


Acta Ophthalmologica | 2012

Lacrymal secretion in the non-affected fellow eye of patients with recurrent unilateral herpetic keratitis

M M'garrech; A Rousseau; Arnaud Sauer; G. Kaswin; E Barreau; Tristan Bourcier; Marc Labetoulle


Acta Ophthalmologica | 2012

Gene transfer of HSV1-specific meganuclease to the murine cornea

A Rousseau; Ayla Ergani; Eric E. Gabison; M Corral; M Gailledrat; C Desseaux; P Roy; B Chapellier; Marc Labetoulle


Acta Ophthalmologica | 2011

Usefulness of dynamic gonioscopy during systematic survey of glaucoma patient in a university hospital

A Rousseau; N Pogorzalek; G. Kaswin; G. Gendron; M M'garrech; Marc Labetoulle


Uvéite (2e édition) | 2017

Chapitre 8 – Uvéites médicamenteuses

A Rousseau; Marc Labetoulle


Archive | 2017

Épidémiologie des uvéites

A Rousseau; Ivan de Monchy; Marc Labetoulle


Acta Ophthalmologica | 2017

Corneal nerves as a biomarker of peripheral neuropathy : the example of transthyretin amyloidosis

A Rousseau; C. Cauquil; Bénédicte Dupas; Antoine Labbé; Christophe Baudouin; C. Lacroix; A. Guiochon-Mantel; A. Benmalek; Marc Labetoulle; D. Adams


Investigative Ophthalmology & Visual Science | 2014

Efficacy of heparin sulfate mimetic polymer in Cogan’s epithelial dystrophy

Marc Labetoulle; A Rousseau; M M'garrech; Bénédicte Dupas; Christophe Baudouin; E Barreau; Tristan Bourcier; F. Chiambaretta

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Ayla Ergani

Centre national de la recherche scientifique

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Nicolas Huot

Centre national de la recherche scientifique

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Arnaud Sauer

University of Strasbourg

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David Pasdeloup

Centre national de la recherche scientifique

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