A. Tóth

Is the MDS-UPDRS a Good Screening Tool for Detecting Sleep Problems and Daytime Sleepiness in Parkinson’s Disease?

Movement Disorder Society-sponsored Unified Parkinsons Disease Rating Scale (MDS-UPDRS) has separate items for measuring sleep problems (item 1.7) and daytime sleepiness (1.8). The aim of our study was to evaluate the screening sensitivity and specificity of these items to the PD Sleep Scale 2nd version (PDSS-2) and Epworth Sleepiness Scale (ESS). In this nationwide, cross-sectional study 460 PD patients were enrolled. Spearmans rank correlation coefficients were calculated between the individual items, domains, and the total score of PDSS-2 and item 1.7 of MDS-UPDRS. Similarly, the items and the total score of ESS were contrasted to item 1.8 of MDS-UPDRS. After developing generalized ordinal logistic regression models, the transformed and observed scores were compared by Lins Concordance Correlation Coefficient. Only item 3 difficulties staying asleep and the “disturbed sleep” domain of PDSS-2 showed high correlation with “sleep problems” item 1.7 of the MDS-UPDRS. Total score of PDSS-2 had moderate correlation with this MDS-UPRDS item. The total score of ESS showed the strongest, but still moderate, correlation with “daytime sleepiness” item 1.8 of MDS-UPDRS. As intended, the MDS-UPDRS serves as an effective screening tool for both sleep problems and daytime sleepiness and identifies subjects whose disabilities need further investigation.

Chromosome Abnormalities in 118 Couples with Recurrent Spontaneous Abortions

Cytogenetic studies were carried out on 118 couples with recurrent spontaneous abortions. Four major chromosomal abnormalities were found including two 13/14 Robertsonian translocations, one t(7;12) and one t(1;10) reciprocal translocation. The incidence of chromosomal abnormalities in this study was 3.39%, which is lower than the mean value of the published data. The clinical significance of balanced translocations in recurrent reproductive loss is discussed.

[Wernicke's encephalopathy induced by the use of diet pills and unbalanced diet].

Wernickes encephalopathy is an acute, potentially life-threatening, neurological syndrome resulting from thiamine deficiency. The disorder is still greatly underdiagnosed and, without prompt treatment, the condition can lead to the chronic form of the disease, Korsakoffs syndrome or even death. In developed countries Wernickes encephalopathy has been associated with alcoholism, but in recent years there has been an increasing number of non-alcoholic cases. Authors report the case of a 23-year-old woman who developed oculomotor dysfunction, encephalopathy and ataxia as a result of an extreme diet and use of diet pills. The diagnosis of Wernickes encephalopathy was supported by the resolution of neurological signs after parenteral thiamine replacement. This case is presented because of the rare etiology and diagnostic difficulty, and the latest diagnostic and therapic guidelines are also highlighted.

Wernicke-encephalopathia kialakulása fogyasztótabletta használata és kiegyensúlyozatlan diéta következtében | Wernicke’s encephalopathy induced by the use of diet pills and unbalanced diet

Wernickes encephalopathy is an acute, potentially life-threatening, neurological syndrome resulting from thiamine deficiency. The disorder is still greatly underdiagnosed and, without prompt treatment, the condition can lead to the chronic form of the disease, Korsakoffs syndrome or even death. In developed countries Wernickes encephalopathy has been associated with alcoholism, but in recent years there has been an increasing number of non-alcoholic cases. Authors report the case of a 23-year-old woman who developed oculomotor dysfunction, encephalopathy and ataxia as a result of an extreme diet and use of diet pills. The diagnosis of Wernickes encephalopathy was supported by the resolution of neurological signs after parenteral thiamine replacement. This case is presented because of the rare etiology and diagnostic difficulty, and the latest diagnostic and therapic guidelines are also highlighted.

Wernicke-encephalopathia kialakulása fogyasztótabletta használata és kiegyensúlyozatlan diéta következtében

Wernickes encephalopathy is an acute, potentially life-threatening, neurological syndrome resulting from thiamine deficiency. The disorder is still greatly underdiagnosed and, without prompt treatment, the condition can lead to the chronic form of the disease, Korsakoffs syndrome or even death. In developed countries Wernickes encephalopathy has been associated with alcoholism, but in recent years there has been an increasing number of non-alcoholic cases. Authors report the case of a 23-year-old woman who developed oculomotor dysfunction, encephalopathy and ataxia as a result of an extreme diet and use of diet pills. The diagnosis of Wernickes encephalopathy was supported by the resolution of neurological signs after parenteral thiamine replacement. This case is presented because of the rare etiology and diagnostic difficulty, and the latest diagnostic and therapic guidelines are also highlighted.

Isolated acute bilateral ophthalmoplegia as a form of anti-GQ1b syndrome - a case report and differential diagnostic considerations

WCN 2013 No: 1101 Topic: 7 — Neuromuscular disorders Isolated acute bilateral ophthalmoplegia as a form of anti-GQ1b syndrome a case report and differential diagnostic considerations A. Toth, G. Aradi, I. Vastagh, K. Pozsegovits, L. Rencz, D. Bereczki, Z. Aranyi. Department of Neurology, Semmelweis University, Faculty of Medicine, Budapest, Hungary; Department of Neurology, Dr. Kenessey Albert Hospital, Balassagyarmat, Hungary Background: Isolated acute bilateral ophthalmoplegia is an uncommon occurrence, but it may cause differential diagnostic problems. It may be a manifestation of the Miller Fisher syndrome spectrum, which has been recently referred to as anti-GQ1b syndrome. Objective: To present a case with acute bilateral ophthalmoplegia associated with anti-GQ1b antibody positivity, but without other typical signs of Miller Fisher syndrome (MFS). Differential diagnostic aspects are highlighted. Patient: A 57-year-old female patient presented with an acute onset of diplopia, progressing to bilateral ophthalmoplegia within days. These symptoms were preceded by flu-like symptoms. Deep tendon reflexes were diminished, otherwise her neurological status was unremarkable, the typical triad of MFSwas not observed. MRI of the brain was normal. Cerebrospinal fluid examination revealed increased protein content with normal cell count. Electrophysiological assessment showed normal sensory nerve action potentials, whereas low amplitude or absent sensory nerve action potentials are characteristic findings in MFS. Serological testing confirmed anti-GQ1b class IgG antibody positivity, supporting the diagnosis of MFS spectrum. The patient fully recovered within 3 months, without any specific treatment, showing the benign nature of the condition. Discussion: Acute ophthalmoparesis may be a restricted form antiGQ1b syndrome. In addition to classical MFS, further variants include Bickerstaffs brainstem encephalitis, pharyngeal-cervical-brachial paresis, and acute ataxic sensory neuropathy. Although acute ophthalmoparesis as a manifestation of anti-GQ1b syndrome is a benign condition, it may cause differential diagnostic problems with potentially more serious conditions needing prompt treatment, such as Wernickes encephalopathy, ocularmyasthenia, botulism, paraneoplastic brainstemencephalitis, or brainstem stroke. doi:10.1016/j.jns.2013.07.1569 Abstract — WCN 2013 No: 1413 Topic: 7 — Neuromuscular disorders “Reporting biomarker” development: Update in als patients treated with G-CSF -mobilized hematopoietic stem cells WCN 2013 No: 1413 Topic: 7 — Neuromuscular disorders “Reporting biomarker” development: Update in als patients treated with G-CSF -mobilized hematopoietic stem cells A.V. Khomenko, D. Baldaranov, J. Grassinger, S.W. Johannesen, I. Kobor, J. Roesl, K. Kollewe, S. Petri, R. Dengler, M. Deppe, A. Ludolph, J. Kassubek, G. Schuierer, T. Bruun, W. Schulte-Mattler, U. Bogdahn. Department of Neurology, University of Regensburg, Regensburg, Germany; Department of Haematology and Internal Oncology, University Hospital Regensburg, Regensburg, Germany; Clinic for Neurology, Medizinische Hochschule Hannover, Hannover, Germany; Department of Neurology, University of Muenster, Muenster, Germany; Neurological University Clinic, University Ulm, Ulm, Germany; Department of Neuroradiology, University of Regensburg,