György Dibó
Eötvös Loránd University
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Featured researches published by György Dibó.
Neuroimmunomodulation | 2005
Cecilia Rajda; György Dibó; László Vécsei; Jonas Bergquist
Objectives: The intracellular (i.c.) content of dopamine and its metabolites was measured in the peripheral blood lymphocytes (PBLs) of Parkinson’s disease (PD) patients and healthy controls. Methods: Catecholamine levels of PBLs were measured using capillary electrophoresis in healthy controls and PD patients receiving different doses of L-dihydroxyphenylalanine (L-Dopa). Results: Higher i.c. dopamine content was found in lymphocytes from PD patients receiving a high dose of L-Dopa (700 ± 30 mg/day) as compared to lymphocytes from the healthy controls (p = 0.002) and from PD patients treated with a low dose of L-Dopa (400 ± 30 mg/day) (p = 0.022). The dihydroxyphenylacetic acid to dopamine ratio was significantly lower in the high-dose L-Dopa-treated PD patients than in the controls (p = 0.013). Conclusions: These findings suggest that the dopamine content and metabolism in the peripheral lymphocytes of PD patients are influenced by L-Dopa administration. This is the first study in which a dose-related effect of L-Dopa treatment was found in lymphocytes from PD patients.
Parkinson's Disease | 2014
Krisztina Horváth; Zsuzsanna Aschermann; Péter Ács; Edit Bosnyák; Gabriella Deli; Endre Pál; J. Janszky; Béla Faludi; Ildikó Késmárki; Sámuel Komoly; Magdolna Bokor; Eszter Rigó; Júlia Lajtos; Péter Klivényi; György Dibó; László Vécsei; Annamária Takáts; A. Tóth; Piroska Imre; Ferenc Nagy; Mihály Herceg; Anita Kamondi; Eszter Hidasi; Norbert Kovács
Movement Disorder Society-sponsored Unified Parkinsons Disease Rating Scale (MDS-UPDRS) has separate items for measuring sleep problems (item 1.7) and daytime sleepiness (1.8). The aim of our study was to evaluate the screening sensitivity and specificity of these items to the PD Sleep Scale 2nd version (PDSS-2) and Epworth Sleepiness Scale (ESS). In this nationwide, cross-sectional study 460 PD patients were enrolled. Spearmans rank correlation coefficients were calculated between the individual items, domains, and the total score of PDSS-2 and item 1.7 of MDS-UPDRS. Similarly, the items and the total score of ESS were contrasted to item 1.8 of MDS-UPDRS. After developing generalized ordinal logistic regression models, the transformed and observed scores were compared by Lins Concordance Correlation Coefficient. Only item 3 difficulties staying asleep and the “disturbed sleep” domain of PDSS-2 showed high correlation with “sleep problems” item 1.7 of the MDS-UPDRS. Total score of PDSS-2 had moderate correlation with this MDS-UPRDS item. The total score of ESS showed the strongest, but still moderate, correlation with “daytime sleepiness” item 1.8 of MDS-UPDRS. As intended, the MDS-UPDRS serves as an effective screening tool for both sleep problems and daytime sleepiness and identifies subjects whose disabilities need further investigation.
Ideggyogyaszati Szemle-clinical Neuroscience | 2016
Zsuzsanna Aschermann; György Dibó; Péter Klivényi; Norbert Kovács; Tibor Kovács; Annamária Takáts; Gertrúd Tamás; Lajos Varannai
The treatment of advanced Parkinsons disease is challenging for both physicians and caregivers. The device-aided therapies need expertise and dedicated hospital centers. In this summary we have concluded the available data and recommendation for the treatment options in advanced Parkinsons disease and adopt them to the daily care in Hungary.
Ideggyogyaszati Szemle-clinical Neuroscience | 2014
Krisztina Horváth; Zsuzsanna Aschermann; Péter Ács; Edit Bosnyák; Gabriella Deli; Endre Pál; Ildikó Késmárki; Réka Horváth; Katalin Takács; Sámuel Komoly; Magdolna Bokor; Eszter Rigó; Júlia Lajtos; Péter Klivényi; György Dibó; László Vécsei; Annamária Takáts; A. Tóth; Piroska Imre; Ferenc Nagy; Mihály Herceg; Eszter Hidasi; Norbert Kovács
Functional Neurology | 1996
Aurélia Ungureán; Sándor Pálfi; György Dibó; László Tiszlavicz; László Vécsei
Ideggyogyaszati Szemle-clinical Neuroscience | 2003
Balázs Kanyó; Miklós Árgyelán; György Dibó; Zsolt Szakonyi; László Vécsei; Ferenc Fülöp; Adrienn Láncz; Péter Forgács; László Pávics
Ideggyogyaszati Szemle-clinical Neuroscience | 2015
Krisztina Horváth; Zsuzsanna Aschermann; Péter Ács; Edit Bosnyák; Gabriella Deli; Endre Pál; Ildikó Késmárki; Réka Horváth; Katalin Takács; Éva Balázs; Sámuel Komoly; Magdolna Bokor; Eszter Rigó; Júlia Lajtos; Annamária Takáts; A. Tóth; Péter Klivényi; György Dibó; László Vécsei; Eszter Hidasi; Ferenc Nagy; Mihály Herceg; Piroska Imre; Norbert Kovács
Ideggyogyaszati Szemle-clinical Neuroscience | 2015
Krisztina Horváth; Zsuzsanna Aschermann; Péter Ács; Edit Bosnyák; Gabriella Deli; Endre Pál; Ildikó Késmárki; Réka Horváth; Katalin Takács; Éva Balázs; Sámuel Komoly; Magdolna Bokor; Eszter Rigó; Júlia Lajtos; Annamária Takáts; A. Tóth; Péter Klivényi; György Dibó; László Vécsei; Eszter Hidasi; Ferenc Nagy; Mihály Herceg; Piroska Imre; Norbert Kovács
Ideggyogyaszati Szemle-clinical Neuroscience | 2012
Peter Balicza; Benjamin Bereznai; Annamária Takáts; Péter Klivényi; György Dibó; Eszter Hidasi; Istvan Balogh; Mária Judit Molnár
Ideggyogyaszati Szemle-clinical Neuroscience | 2014
Helga Nagy; Annamária Takáts; A. Tóth; Dániel Bereczki; Péter Klivényi; Livia Dézsi; György Dibó; László Vécsei; Norbert Kovács; Zsuzsanna Aschermann; Sámuel Komoly; Lajos Varannai; Gyöngyi Zemlényi; Attila Valikovics