Abdel-Zaher A. Elassar

A Microwave Assisted Diazo Coupling Reaction: The Synthesis of Alkylazines and Thienopyridazines

Heating diazoaminobenzene with active methylene compounds 1–3 in microwave oven in acetic acid, in the presence of hydrochloric acid, afforded the corresponding arylhydrazones 5–7. These reaction products were condensed with ethyl cyanoacetate in a domestic microwave oven after 1–2 minutes heating to yield the pyridazinones 8–12. Compounds 8c and 12 reacted with sulfur in basic DMF solution, in microwave oven using MORE technology to yield the thienopyridazinone 14 and 16 respectively. While 17 was produced when 8b was treated like wise with sulfur and DMF in the presence of piperidine. Compounds 16 coupled with aromatic diazonium salts to yield arylazo derivatives 21a–c.

Synthesis, characterisation and bioactivity of polysubstituted 1-(4-(1H-pyrrol-1-yl)phenyl)-1H-pyrrole derivatives

1,4-Phenylenediamine reacted readily with chloroacetone to give 1,4-bis[(2-oxopropyl)amino]benzene which was used to prepare 1-(4-(1H-pyrrol-1-yl)phenyl)-1H-pyrrole derivatives in a one pot reaction with dimethylformamide dimethylacetal or triethyl orthoformate and an active methylene nitrile, an active methylene ketone or an ylidene-malononitrile. Reaction of 1,4-bis[(2-oxopropyl)amino]benzene with arene diazonium salts afforded the hydrazone derivatives which readily cyclised when reacted with malononitrile to give bispyrrole derivatives. The antibacterial activity of some of the products was determined.

Bridgehead Nitrogen Thiazolopyrimidines

Abstract This review article includes a recent development in the chemistry of bridgehead nitrogen thiazolpoyrimidines. Synthetic approaches with respect to the four different ring systems were reported. Chemical reactivity, experimental structural methods, biological activity, basicity of thiazole heterocyclic compounds, and applications were also reported. This review includes 126 references.

A Novel Synthesis of Cyclopenta[c]pyridazines and 1,8-Ethanophthalazinones: A New Ring System

The synthesis of 1,8-ethanophthalazine derivatives from reaction of cyclopenta[c]pyridazines with arylidenemalononitrile or active methylene nitriles is described.

Synthesis of N-substituted arylhydrazones: applying to polyester fabric as disperse dyes

Purpose The purpose of this paper is to prepare new disperse dyes and apply for dying polyester fabrics. Design/methodology/approach The synthetic reaction was carried out through two steps: preparation of arylhydrazones and alkylation using enaminone and dimethylaminovinyl-pyridazine. The high temperature method was used to apply these dyes to polyester fibres. Findings The study revealed that there is a significant effect of the new prepared disperse dyes on polyester fabrics. The structures of the prepared dyes were established based on elemental analysis and spectral data (infra red (IR), mass spectrometry (MS) and proton nuclear magnetic resonance (1H-NMR), carbon 13th nuclear magnetic resonance (13C-NMR)). Research limitations/implications Disperse dyes containing heterocyclic moiety have attracted great academic and industrial attention owing to their significant. The potential of using disperse dyes easily prepared from arylhydrazones are promise broad applications for these dyes. Practical implications The presence of N-thienyl and N-pyridazinyl in the structure of the synthesised disperse dyes would be expected to add the bioactivity advantage. Also, it can be used in formulating the antimicrobial fabrics. Social implications The N-thienyl and N-pyrdiazinyl derivatives of azo dyes are expected to be superior to in the application for fabrics. It may be useful for other applications like painting. Originality/value This paper helps to synthesise novel thiophene or pyridazine-based dyestuff for application in dying properties on polyester fabric and study their fastness properties.